2023
A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
Katamba A, Gupta A, Turimumahoro P, Ochom E, Ggita J, Nakasendwa S, Nanziri L, Musinguzi J, Hennein R, Sekadde M, Hanrahan C, Byaruhanga R, Yoeli E, Turyahabwe S, Cattamanchi A, Dowdy D, Haberer J, Armstrong-Hough M, Kiwanuka N, Davis J. A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial. BMC Public Health 2023, 23: 1568. PMID: 37592314, PMCID: PMC10436440, DOI: 10.1186/s12889-023-16510-0.Peer-Reviewed Original ResearchConceptsContact investigationClinical effectiveness outcomesPrimary implementation outcomeTB contact investigationTB preventative therapyTB treatment initiationTimely TB diagnosisTrial registrationThe trialTuberculosis contact investigationCluster-randomised trialHigh-burden settingsImplementation-effectiveness trialEvidence-based interventionsUganda National CouncilWorld Health OrganizationProportion of contactsTB evaluationPeer-reviewed journalsMiddle-income countriesTreatment initiationTB diagnosisPreventative therapyUndiagnosed personsInfectious deathSputum samplesExploring stakeholders perspectives on TB contact investigation in Cali, Colombia: a qualitative study
Velosa J, Gómez J, Zúñiga C, Díaz G, Ferro B, Davis J, Grau L. Exploring stakeholders perspectives on TB contact investigation in Cali, Colombia: a qualitative study. Frontiers In Public Health 2023, 11: 1204862. PMID: 37564424, PMCID: PMC10411903, DOI: 10.3389/fpubh.2023.1204862.Peer-Reviewed Original ResearchConceptsTB contact investigationContact investigationPublic health staffHealth workersHousehold contactsTB knowledgeTB casesTest uptakeHealth staffHousehold visitsHealth OrganizationTuberculosis case findingNational public health authoritiesPublic health authoritiesWorld Health OrganizationPublic health organizationsMiddle-income countriesTB controlCase findingThematic analysisHealth authoritiesDiagnostic testsInductive thematic analysisSemi-structured interviewsMain barriers
2022
Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda
Byanyima P, Kaswabuli S, Musisi E, Nabakiibi C, Zawedde J, Sanyu I, Sessolo A, Andama A, Worodria W, Huang L, Davis JL. Feasibility and Sensitivity of Saliva GeneXpert MTB/RIF Ultra for Tuberculosis Diagnosis in Adults in Uganda. Microbiology Spectrum 2022, 10: e00860-22. PMID: 36154664, PMCID: PMC9603304, DOI: 10.1128/spectrum.00860-22.Peer-Reviewed Original ResearchConceptsGeneXpert MTB/RIF UltraMTB/RIF UltraXpert UltraTB diagnosisMolecular testingHigh TB burden settingsCulture-confirmed TB casesSaliva samplesTB diagnostic evaluationActive tuberculosis diseaseProspective observational studyActive TB diagnosisCause of morbidityAcid-fast bacilliComposite reference standardReference standardCase-only studySingle saliva sampleWorld Health OrganizationSpot sputumTB evaluationConsecutive adultsTB casesBurden settingsOutpatient department
2019
Home-based tuberculosis contact investigation in Uganda: a household randomised trial
Davis JL, Turimumahoro P, Meyer AJ, Ayakaka I, Ochom E, Ggita J, Mark D, Babirye D, Okello DA, Mugabe F, Fair E, Vittinghoff E, Armstrong-Hough M, Dowdy D, Cattamanchi A, Haberer JE, Katamba A. Home-based tuberculosis contact investigation in Uganda: a household randomised trial. ERJ Open Research 2019, 5: 00112-2019. PMID: 31367636, PMCID: PMC6661318, DOI: 10.1183/23120541.00112-2019.Peer-Reviewed Original ResearchCommunity health workersTB contact investigationTuberculosis contact investigationContact investigationTB evaluationIndex patientsWorld Health OrganizationIntervention armHousehold tuberculosis contact investigationCare armHousehold contactsPulmonary TBSputum testingCare contactsHIV diagnosisSecondary outcomesHIV testingPrimary outcomeSymptomatic contactsHealth workersMicrobiologic testingHome evaluationIntervention componentsSputumPatients
2017
Identifying barriers to and facilitators of tuberculosis contact investigation in Kampala, Uganda: a behavioral approach
Ayakaka I, Ackerman S, Ggita JM, Kajubi P, Dowdy D, Haberer JE, Fair E, Hopewell P, Handley MA, Cattamanchi A, Katamba A, Davis JL. Identifying barriers to and facilitators of tuberculosis contact investigation in Kampala, Uganda: a behavioral approach. Implementation Science 2017, 12: 33. PMID: 28274245, PMCID: PMC5343292, DOI: 10.1186/s13012-017-0561-4.Peer-Reviewed Original ResearchConceptsLay health workersTB contact investigationTuberculosis contact investigationContact investigationTB patientsHousehold contactsBackgroundThe World Health OrganizationIndex TB patientsHigh-burden countriesHousehold tuberculosis contact investigationHealth center staffHealth care workersWorld Health OrganizationFocus group discussionsScreening visitCross-sectional qualitative dataRelevant intervention functionsIndex patientsHealth workersRisk contactsPatientsTargeted interventionsClinicHealth OrganizationConclusionsThe use