Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes
ELSHAFIE A, LAM W, PARIKH L, RANGEL E, SCHMIDT C, HWANG J, YECKEL C, SHERWIN R, BELFORT-DEAGUIAR R. Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes. Diabetes 2018, 67 DOI: 10.2337/db18-82-lb.Peer-Reviewed Original ResearchGlucose infusion rateInsulin secretion-sensitivity index-2Beta-cell functionContinuous overlapping net glycemic actionGlucose variabilityContinuous glucose monitorT2D subjectsObese subjectsInsulin levelsGV indicesGlucose metabolismCell functionInsulin sensitivity indexType 2 diabetesGlycemic Risk AssessmentCGM indicesHealthy obesityMannKind CorporationHealthy obeseOB subjectsGlycemic excursionsInsulin resistanceIncremental AUCGlycemic variabilityRegeneron PharmaceuticalsHypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity
GROSKREUTZ D, HWANG J, SEO D, LACADIE C, PARIKH L, BELFORT-DEAGUIAR R, SCHEINOST D, SINHA R, CONSTABLE T, SHERWIN R. Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity. Diabetes 2018, 67 DOI: 10.2337/db18-11-lb.Peer-Reviewed Original ResearchDefault mode networkHypoglycemia awarenessDMN connectivityAvoidance of hypoglycemiaDefault mode network connectivityHypoglycemia symptom scoresMode network connectivityBrain connectivity patternsBOLD-fMRI scanningMannKind CorporationT1DM individualsHypoglycemia unawarenessHypoglycemic clampSymptom scoresRegeneron PharmaceuticalsGlaxoSmithKline plcPlasma cortisolState connectivityMode networkFMRI scanningHypoglycemiaElicit changesBrainFunctional networksConnectivity patterns