2008
Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma
Choi YJ, M Pinto M, Hao L, K Riba A. Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. Modern Pathology 2008, 21: 1224-1237. PMID: 18587329, DOI: 10.1038/modpathol.2008.106.Peer-Reviewed Original ResearchConceptsE-cadherin stainingLobular carcinomaLobular neoplasiaDuct lesionsDuct carcinomaPrevious diagnosisBreast lesionsMorphologic diagnosisInterobserver variabilityDifferent antibodiesE-cadherinImportant therapeutic implicationsParaffin-embedded sectionsLoss of stainingE-cadherin staining patternDuctal neoplasiaDuctal lesionsHistologic featuresLobular lesionsHistology diagnosisSurgical pathologistsImmunohistochemistry techniquesTherapeutic implicationsBlinded mannerCarcinomaGenotypic Analysis of Hydatidiform Mole: An Accurate and Practical Method of Diagnosis
Bifulco C, Johnson C, Hao L, Kermalli H, Bell S, Hui P. Genotypic Analysis of Hydatidiform Mole: An Accurate and Practical Method of Diagnosis. The American Journal Of Surgical Pathology 2008, 32: 445-451. PMID: 18300805, DOI: 10.1097/pas.0b013e3181520034.Peer-Reviewed Original ResearchConceptsMolar pregnancyMaternal endometrial tissuesDaily clinical practiceDNA ploidy analysisDNA genotypingCases of HMUnstained paraffin sectionsHistologic featuresEndometrial tissueMorphologic mimicsClinical practiceMolar gestationHydatidiform MoleParaffin sectionsChorionic villiDiagnosisRoutine diagnosisPregnancyPloidy analysisGenotypic analysisGenotypingPaternal originPCR amplification systemGestationCases
2006
Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
Rakoff-Nahoum S, Hao L, Medzhitov R. Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis. Immunity 2006, 25: 319-329. PMID: 16879997, DOI: 10.1016/j.immuni.2006.06.010.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseToll-like receptorsAbsence of TLRDevelopment of IBDEtiology of IBDImmune systemIL-10-deficient miceImmune suppressive mechanismsInnate immune recognitionHost immune systemBowel diseaseIntestinal inflammationColitisCommensal microfloraImmune recognitionMiceMultiple mechanismsDisease susceptibilityDifferential rolesReceptorsInflammationInterleukinMicrofloraEtiologyDisease
2005
Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response
Peng T, Hao L, Madri JA, Su X, Elias JA, Stahl GL, Squinto S, Wang Y. Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response. Journal Of Clinical Investigation 2005, 115: 1590-1600. PMID: 15902311, PMCID: PMC1090470, DOI: 10.1172/jci22906.Peer-Reviewed Original ResearchConceptsAirway hyperresponsivenessAirway inflammationContribution of C5Airway responsesDevelopment of AHRHarmful inflammatory mediatorsRole of C5C5-deficient miceCourse of diseaseDownstream inflammatory cascadesInnate immune systemPotential clinical approachCritical checkpointAllergen provocationComplement component C5Inflammatory mediatorsInflammatory cascadeAirway lumenInflammatory cellsC5 inhibitionNonspecific stimuliClinical approachImmune systemInflammationC5b-9
2002
Murine model of gastrointestinal ischemia associated with complement-dependent injury
Zhao H, Montalto MC, Pfeiffer KJ, Hao L, Stahl GL. Murine model of gastrointestinal ischemia associated with complement-dependent injury. Journal Of Applied Physiology 2002, 93: 338-345. PMID: 12070223, DOI: 10.1152/japplphysiol.00159.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsColoring AgentsComplement C5Complement System ProteinsDigestive SystemGastrointestinal DiseasesImmunohistochemistryIntercellular Adhesion Molecule-1IntestinesL-Lactate DehydrogenaseLungMaleMiceMice, Inbred C57BLMice, KnockoutPeroxidaseRegional Blood FlowReperfusion InjuryReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionConceptsRemote tissue injuryTissue injuryGastrointestinal ischemiaMurine modelComplement-mediated tissue injuryIntercellular adhesion molecule-1 mRNAAnti-C5 treatmentComplement-dependent injuryInflammatory protein-2 mRNAIschemia-reperfusion injuryAttenuates tissue injuryNew murine modelC5 monoclonal antibodyNeutrophil accumulationNeutrophil infiltrationNeutrophil recruitmentProtein-2 mRNAChemokine expressionActivate complementInjuryAdherence moleculesComplement activationMonoclonal antibodiesProtein expressionLactate dehydrogenase
1992
Facilitation of specific tolerance induction in adult mice by RS-61443.
Hao L, Calcinaro F, Gill RG, Eugui EM, Allison AC, Lafferty KJ. Facilitation of specific tolerance induction in adult mice by RS-61443. Transplantation 1992, 53: 590-5. PMID: 1549852.Peer-Reviewed Original Research
1990
Role of lymphokine in islet allograft rejection.
Hao LM, Wang Y, Gill RG, La Rosa FG, Talmage DW, Lafferty KJ. Role of lymphokine in islet allograft rejection. Transplantation 1990, 49: 609-14. PMID: 1969186.Peer-Reviewed Original Research
Others
- Kamanaka M, Kim ST, Hao L,and Flavell RA. A direct IL-10 signal to T cell is required to generate IL-10 producing T cells and to maintain the intestinal integrity. Manuscript submittedPeer-Reviewed Original Research