2024
Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene
Atzmony L, Zagairy F, Mawassi B, Shehade M, Tatour Y, Danial-Farran N, Khayat M, Warrour N, Dodiuk-Gad R, Cohen-Barak E. Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene. JAMA Dermatology 2024, 160: 518-524. PMID: 38536168, PMCID: PMC10974685, DOI: 10.1001/jamadermatol.2024.0152.Peer-Reviewed Original ResearchConceptsSomatic variantsATP2A2 geneDeep sequencingResponse to environmental factorsCopy number variantsRestriction fragment length polymorphismLoss of heterozygosityWhole-exome sequencingChromosomal microarray analysisDarier's diseaseFragment length polymorphismPaired whole exome sequencingPathogenic germline variantsHeterozygous pathogenic germline variantsDD lesionsGenomic characteristicsGenetic analysisGenetic skin disordersGermline variantsSanger sequencingLength polymorphismSkin lesionsTransient lesionsHeterozygous variantsMicroarray analysis
2020
Mutations in KRT10 in epidermolytic acanthoma
Cheraghlou S, Atzmony L, Roy SF, McNiff JM, Choate KA. Mutations in KRT10 in epidermolytic acanthoma. Journal Of Cutaneous Pathology 2020, 47: 524-529. PMID: 32045015, PMCID: PMC7914398, DOI: 10.1111/cup.13664.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingEpidermolytic acanthomaEpidermolytic hyperkeratosisHotspot mutationsCharacteristic histopathological patternEpidermolytic ichthyosisHistopathological patternsHistopathological analysisDiscovery cohortLesional tissueAdditional casesPolymerase chain reaction amplificationEpidermal degenerationChain reaction amplificationFragment length polymorphism analysisRestriction fragment length polymorphism analysisLength polymorphism analysisDermatosesIchthyosis bullosaAcanthomaKRT10Departmental archivesReaction amplificationIchthyosisPolymorphism analysis
2019
Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy
Atzmony L, Lim YH, Hamilton C, Leventhal JS, Wagner A, Paller AS, Choate KA. Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy. Journal Of The American Academy Of Dermatology 2019, 82: 123-131. PMID: 31449901, PMCID: PMC7039698, DOI: 10.1016/j.jaad.2019.08.043.Peer-Reviewed Original ResearchConceptsPorokeratosis lesionsPorokeratosis palmaris et plantaris disseminataPathogenesis-directed therapyTreatment of porokeratosisWeeks of therapyInitiation of therapyPathway gene mutationsDisseminated superficial actinic porokeratosisPathogenesis-based therapiesCase series designSuperficial actinic porokeratosisAdverse eventsTopical therapyTherapeutic optionsComplete clearanceLinear porokeratosisPatientsActinic porokeratosisTherapyPorokeratosisLesionsGene mutationsModerate improvementLovastatinToxic metabolites
2018
Psychological stress and psoriasis: a systematic review and meta‐analysis
Snast I, Reiter O, Atzmony L, Leshem Y, Hodak E, Mimouni D, Pavlovsky L. Psychological stress and psoriasis: a systematic review and meta‐analysis. British Journal Of Dermatology 2018, 178: 1044-1055. PMID: 29124739, DOI: 10.1111/bjd.16116.Peer-Reviewed Original ResearchConceptsCase-control studyOdds ratioPsychological stressExacerbation of psoriasisOnset of psoriasisCross-sectional studyStress disorder diagnosisStressful eventsPsoriasis exacerbationRetrospective studyCohort studySystematic reviewMeta-analysesPsoriasisCochrane LibraryMeta-analysisPatientsExacerbationDisorder diagnosisStress reactivityAssociationSurveyStress levelsPsycINFOOdds
2017
Venous thromboembolism in patients with pemphigus: A cohort study
Leshem Y, Atzmony L, Dudkiewicz I, Hodak E, Mimouni D. Venous thromboembolism in patients with pemphigus: A cohort study. Journal Of The American Academy Of Dermatology 2017, 77: 256-260. PMID: 28495498, DOI: 10.1016/j.jaad.2017.01.059.Peer-Reviewed Original ResearchConceptsVenous thromboembolism riskDevelopment of venous thromboembolismVenous thromboembolism risk factorsVenous thromboembolismCharacteristics of venous thromboembolismRisk factorsAsymptomatic venous thromboembolismDeep vein thrombosesFollow-up timeVenous thromboembolic eventsPemphigus diagnosisPemphigus treatmentPatient yearsPulmonary embolismVein thrombosesCause of deathRetrospective studyThrombo-prophylaxisHealth recordsPatientsHigh riskPemphigusDiagnosed pemphigusControl populationThromboembolismRisk for hepatitis B and C virus reactivation in patients with psoriasis on biologic therapies: A retrospective cohort study and systematic review of the literature
Snast I, Atzmony L, Braun M, Hodak E, Pavlovsky L. Risk for hepatitis B and C virus reactivation in patients with psoriasis on biologic therapies: A retrospective cohort study and systematic review of the literature. Journal Of The American Academy Of Dermatology 2017, 77: 88-97.e5. PMID: 28495497, DOI: 10.1016/j.jaad.2017.01.037.Peer-Reviewed Original ResearchConceptsChronic HBV infectionBiologic therapyHBV infectionViral reactivationAntiviral prophylaxisCore antibodyHCV infectionHepatitis BSafety of biologic therapiesHistory of viral hepatitisSystematic reviewIsolated core antibodyHBV core antibodyLow-risk patientsRetrospective cohort study designRetrospective cohort studyReactivated HBV infectionCohort study designPsoriasis patientsViral hepatitisEvaluate safetyFollow-upCohort studyPrimary outcomeTreatment duration
2016
Picosecond lasers for tattoo removal: a systematic review
Reiter O, Atzmony L, Akerman L, Levi A, Kershenovich R, Lapidoth M, Mimouni D. Picosecond lasers for tattoo removal: a systematic review. Lasers In Medical Science 2016, 31: 1397-1405. PMID: 27311768, DOI: 10.1007/s10103-016-2001-0.Peer-Reviewed Original ResearchConceptsSide effectsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsNon-comparative studyRegister of Controlled TrialsReported side effectsCochrane Central RegisterClearance of pigmentTattoo pigmentTattoo removalTransient erythemaLaser sessionsPrimary outcomeSecondary outcomesHuman trialsAnimal modelsRelevant trialsHigh riskInk tattooingControlled trialsNew insights into folliculotropic mycosis fungoides (FMF): A single-center experience
Hodak E, Amitay-Laish I, Atzmony L, Prag-Naveh H, Yanichkin N, Barzilai A, Kershenovich R, Feinmesser M. New insights into folliculotropic mycosis fungoides (FMF): A single-center experience. Journal Of The American Academy Of Dermatology 2016, 75: 347-355. PMID: 27245278, DOI: 10.1016/j.jaad.2016.03.009.Peer-Reviewed Original ResearchConceptsFolliculotropic mycosis fungoidesMycosis fungoidesPattern of clinicopathological featuresAdvanced stageLong-term follow-upLack of long-term follow-upTertiary medical centerEarly-stage lesionsEarly-stage groupPresence of eosinophilsAggressive courseTumor stageClinicopathological presentationHistopathological discriminationPerifollicular infiltratePrognostic implicationsClinicopathological featuresInfiltration densityAcneiform lesionsClinical manifestationsIndurated plaquesFollow-upMultivariate analysisTumorMedical Center
2015
Erythrodermic mycosis fungoides and Sézary syndrome treated with extracorporeal photopheresis as part of a multimodality regimen: A single‐centre experience
Atzmony L, Amitay-Laish I, Gurion R, Shahal-Zimra Y, Hodak E. Erythrodermic mycosis fungoides and Sézary syndrome treated with extracorporeal photopheresis as part of a multimodality regimen: A single‐centre experience. Journal Of The European Academy Of Dermatology And Venereology 2015, 29: 2382-2389. PMID: 26299651, DOI: 10.1111/jdv.13243.Peer-Reviewed Original ResearchConceptsExtracorporeal photopheresisErythrodermic mycosis fungoidesSezary syndromeLeukaemic involvementMycosis fungoidesErythrodermic MFTreated with extracorporeal photopheresisBlood responseNarrow-band ultraviolet BSkin responsePatch-stage MFClinical response rateElectron beam radiotherapyTopical nitrogen mustardTertiary medical centreMultimodal approachBeam radiotherapyMultimodality regimenClinical responseAdjunctive therapyInterferon-aSurvival advantageMedical filesPhotopheresisPatients
2010
Thrombosis associated with acute cytomegalovirus infection: A meta-analysis
Justo D, Finn T, Atzmony L, Guy N, Steinvil A. Thrombosis associated with acute cytomegalovirus infection: A meta-analysis. European Journal Of Internal Medicine 2010, 22: 195-199. PMID: 21402253, DOI: 10.1016/j.ejim.2010.11.006.Peer-Reviewed Original ResearchConceptsAcute CMV infectionSplanchnic vein thrombosisCMV infectionImmunocompetent patientsImmunocompromised patientsVein thrombosisTreated with antiviral agentsDuration of anticoagulant therapyClinical characteristics of patientsIn-hospital mortality rateSigns of thrombosisIncidence of thrombosisCharacteristics of patientsAcute cytomegalovirusAnticoagulant therapyFemale-male ratioClinical characteristicsSplenic infarctionInherited predispositionHospitalized patientsThrombosisPatientsAntiviral agentsMedical literatureClinical experienceIncidence of Cytomegalovirus-associated thrombosis and its risk factors: A case-control study
Atzmony L, Halutz O, Avidor B, Finn T, Zimmerman O, Steinvil A, Zeltser D, Giladi M, Justo D. Incidence of Cytomegalovirus-associated thrombosis and its risk factors: A case-control study. Thrombosis Research 2010, 126: e439-e443. PMID: 20926120, DOI: 10.1016/j.thromres.2010.09.006.Peer-Reviewed Original ResearchConceptsAcute CMV infectionAssociated with thrombosisCMV infectionConsecutive patientsRisk factorsControl groupSex-matched consecutive patientsStudy groupCohort of patientsTertiary medical centerConsecutive matched patientsBinary logistic regression analysisLogistic regression analysisVenous thrombosesVenous thrombosisMatched patientsThrombosis incidenceInherited predispositionMedical chartsArterial thrombosisPhysician awarenessThrombosisAge-matchedPatientsMedical Center
2009
Inherited and acquired predispositions for thrombosis in immunocompetent patients with cytomegalovirus-associated thrombosis
Atzmony L, Grosfeld A, Saar N, Justo D. Inherited and acquired predispositions for thrombosis in immunocompetent patients with cytomegalovirus-associated thrombosis. European Journal Of Internal Medicine 2009, 21: 2-5. PMID: 20122604, DOI: 10.1016/j.ejim.2009.10.002.Peer-Reviewed Original ResearchConceptsImmunocompetent adultsInherited predispositionImmunocompetent patientsFactor V Leiden mutationV Leiden mutationThrombosis risk factorsImmunocompromised patientsInherited thrombophiliaOral contraceptivesCase seriesCase reportElderly patientsClinical circumstancesThrombosisClinical importanceRisk factorsPatientsPredispositionComplicationsCMVAdultsReportsThrombophiliaContraceptionInfantsC-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia
Justo D, Lachmi S, Saar N, Joffe E, Atzmony L, Mashav N, Henis O, Sade B, Chundadze T, Steinvil A, Paran Y. C-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia. European Journal Of Internal Medicine 2009, 20: 518-521. PMID: 19712857, DOI: 10.1016/j.ejim.2009.03.008.Peer-Reviewed Original ResearchConceptsCAP patientsChronic obstructive pulmonary disease exacerbationsCommunity acquired pneumoniaChronic obstructive pulmonary diseaseInitiation of antibacterial treatmentChronic obstructive pulmonary disease exacerbation patientsCRP levelsExacerbation patientsC-reactive protein velocityAntibacterial treatmentTreated with cephalosporinsChronic obstructive pulmonary disease patientsDays of hospitalizationChest X-rayInternal medicine departmentObstructive pulmonary diseaseProductive coughAntibiotic administrationDisease exacerbationStudy groupPulmonary diseaseCRPPatientsExacerbationMedicine department