2023
Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing
Moradi L, Witek L, Vivekanand Nayak V, Cabrera Pereira A, Kim E, Good J, Liu C. Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing. Biomaterials 2023, 301: 122289. PMID: 37639975, PMCID: PMC11232488, DOI: 10.1016/j.biomaterials.2023.122289.Peer-Reviewed Original ResearchConceptsΒ-GP hydrogelPorous interconnected structureAmount of GOTissue engineering applicationsEngineering applicationsLong-term storage stabilityInjectable biomaterialsGrowth factor deliveryInjectable hydrogelsInterconnected structureHigh viscosityRapid sol-gel transitionHydrogelsSustained-release propertiesFactor deliveryBiomechanical environmentStorage stabilitySustained deliverySol-gel transitionExcellent candidateCartilage regenerationGel networkSustained releaseChitosanFracture healing
2021
Effect of ECAP on Physicochemical and Biological Properties of TiO2 Nanotubes Anodized on Commercially Pure Titanium
Chehrehsaz Y, Hajizadeh K, Hadjizadeh A, Moradi L, Mahshid S. Effect of ECAP on Physicochemical and Biological Properties of TiO2 Nanotubes Anodized on Commercially Pure Titanium. Metals And Materials International 2021, 28: 1525-1535. DOI: 10.1007/s12540-021-01003-9.Peer-Reviewed Original ResearchEqual Channel Angular PressingLow tensile strengthPure titaniumAnodic TiO2 nanotubesCG TiTiO2 nanotubesTensile strengthTitania nanotube formationUltrafine-grained titaniumCP-Ti substrateProper mechanical propertiesChannel Angular PressingSurface oxide layerCommercially Pure TitaniumAnodic nanotube arraysUFG TiCorrosion resistanceAdvantages of titaniumGrain refinementMetallic biomaterialsOxide layerAngular PressingMechanical propertiesNanotube arraysAnodic TiO2Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair
Abpeikar Z, Moradi L, Javdani M, Kargozar S, Soleimannejad M, Hasanzadeh E, Mirzaei S, Asadpour S. Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair. Cartilage 2021, 13: 1583s-1601s. PMID: 34340598, PMCID: PMC8804732, DOI: 10.1177/19476035211035418.Peer-Reviewed Original ResearchConceptsComposite scaffoldsSuitable mechanical propertiesSelf-healing capacityMechanical propertiesMechanical testsElectron microscopeInner avascular zoneAllogeneic adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsGood biocompatibilityMeniscus cartilageScaffoldsCarbodiimide hydrochlorideCartilage repairAntioxidant capacityNew Zealand rabbitsTotal antioxidant capacityBiocompatibilityInfluence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes
Abpeikar Z, Milan P, Moradi L, Anjomshoa M, Asadpour S. Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes. Mechanics Of Advanced Materials And Structures 2021, 29: 4911-4922. DOI: 10.1080/15376494.2021.1943077.Peer-Reviewed Original ResearchMacroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assaysDetection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix
Ghorbani F, Ekhtiari M, Moeini Chaghervand B, Moradi L, Mohammadi B, Kajbafzadeh A. Detection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix. Cell And Tissue Banking 2021, 23: 119-128. PMID: 33909237, DOI: 10.1007/s10561-021-09921-z.Peer-Reviewed Original Research
2020
Stem Cells and Hydrogels for Liver Tissue Engineering: Synergistic Cure for Liver Regeneration
Nadi A, Moradi L, Ai J, Asadpour S. Stem Cells and Hydrogels for Liver Tissue Engineering: Synergistic Cure for Liver Regeneration. Stem Cell Reviews And Reports 2020, 16: 1092-1104. PMID: 33070256, DOI: 10.1007/s12015-020-10060-3.Peer-Reviewed Original ResearchCoronavirus disease 2019: A tissue engineering and regenerative medicine perspective
Shafiee A, Moradi L, Lim M, Brown J. Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective. Stem Cells Translational Medicine 2020, 10: 27-38. PMID: 32820868, PMCID: PMC7461291, DOI: 10.1002/sctm.20-0197.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeMesenchymal stem cellsCoronavirus infectionCOVID-19Significant unmet medical needRespiratory distress syndromeRecent clinical trialsMajority of deathsUnmet medical needNovel coronavirus diseaseDistress syndromeCurrent therapiesMSC therapyClinical trialsDisease progressionEffective treatmentTherapeutic benefitAntiviral agentsInfective diseasesTissue engineeringMedical needVaccine technologyCoronavirus diseaseInfectionMedicine perspectiveCorneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface
Nosrati H, Abpeikar Z, Mahmoudian Z, Zafari M, Majidi J, Alizadeh A, Moradi L, Asadpour S. Corneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface. Regenerative Medicine 2020, 15: 2029-2044. PMID: 33169642, DOI: 10.2217/rme-2019-0055.Peer-Reviewed Original ResearchConceptsNative tissue microenvironmentCorneal tissue engineeringTissue engineeringCorneal regenerationCurrent clinical techniquesCell-based approachesRegenerative strategiesPromising approachBiological propertiesCorneal replacementRecent advancesCorneal transplantationCorneal diseaseSevere casesCornea donorsCorneal implantsCorneal surfaceInfection transmissionCorneal implantationClinical techniquesRegenerationBiomaterialsDifferent cell typesTissue microenvironmentNew approachDelivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model
Alizadeh A, Moradi L, Katebi M, Ai J, Azami M, Moradveisi B, Ostad S. Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model. Journal Of Tissue Viability 2020, 29: 359-366. PMID: 32839065, DOI: 10.1016/j.jtv.2020.06.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryHuman adipose-derived mesenchymal stem cellsNerve growth factorSpinal cord regenerationCord regenerationGrowth factorBetter locomotor functionBetter therapeutic strategiesPositive control groupRat animal modelAdipose-derived mesenchymal stem cellsSCI treatmentSham groupSurgical interventionCord injuryLocomotor functionSCI siteTherapeutic strategiesAnimal modelsControl groupMesenchymal stem cellsHistological studyBeneficial effectsRats animalsOne weekEvaluation of different sterilization methods for decellularized kidney tissue
Moradi L, Mohammadi Jobania B, Jafarnezhad-Ansariha F, Ghorbani F, Esmaeil-Pour R, Majidi Zolbina M, Kajbafzadeh A. Evaluation of different sterilization methods for decellularized kidney tissue. Tissue And Cell 2020, 66: 101396. PMID: 32933719, DOI: 10.1016/j.tice.2020.101396.Peer-Reviewed Original Research
2019
Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications
Asadpour S, Kargozar S, Moradi L, Ai A, Nosrati H, Ai J. Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications. International Journal Of Biological Macromolecules 2019, 154: 1285-1294. PMID: 31733251, DOI: 10.1016/j.ijbiomac.2019.11.003.Peer-Reviewed Original ResearchConceptsComposite scaffoldsTissue engineering applicationsSilk fibroinMechanical strengthEngineering applicationsFabricated composite scaffoldsNatural extra cellular matrixBiocompatibility of scaffoldsDifferent blending ratiosFreeze-drying techniqueSilk fibroin-chitosanGood interconnectivityTensile testsSuitable porositySurface wettabilityBlending ratioDegradation measurementsBombyx mori silkwormPore sizeChitosan-gelatinFibroinCell affinityDegradation rateExtra-cellular matrixWater uptakeModulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis
Samiei N, Hosseini S, Maleki M, Moradi L, Joghataei M, Arabian M. Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis. Archives Of Medical Research 2019, 50: 333-341. PMID: 31677538, DOI: 10.1016/j.arcmed.2019.10.001.Peer-Reviewed Original ResearchConceptsSilent information regulator 1Aortic valve stenosisPeripheral blood mononuclear cellsResistin levelsValve stenosisAS groupExpression of SIRT1Modulatory roleAortic valve replacementLevels of resistinBlood mononuclear cellsInformation regulator 1Effects of resveratrolAS preventionValve replacementPharmacological therapyMononuclear cellsResistin expressionSIRT1 expressionTargeted therapySIRT1 levelsTherapeutic effectHealthy subjectsNovel biomarkersTherapeutic targetControlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques
Amani H, Arzaghi H, Bayandori M, Dezfuli A, Pazoki‐Toroudi H, Shafiee A, Moradi L. Controlling Cell Behavior through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques. Advanced Materials Interfaces 2019, 6 DOI: 10.1002/admi.201900572.Peer-Reviewed Original ResearchFunctionality of biomaterialsSurface modification techniquesBioactive ligandsChemical strategiesBulk material propertiesSurface modificationBiomaterial-cell interfaceSurface propertiesBiomaterial surfacesSurface interactionsMaterial propertiesMaterial interfacesCellular responsesModification techniquesTissue engineeringRegenerative medicine applicationsBiomaterialsDifferent cellular responsesHigh functionalitySpecific cell signalingCellular functionsCell signalingInterface levelBiointerfacesMedicine applications
2017
An engineered cell-imprinted substrate directs osteogenic differentiation in stem cells
Kamguyan K, Katbab A, Mahmoudi M, Thormann E, Zajforoushan Moghaddam S, Moradi L, Bonakdar S. An engineered cell-imprinted substrate directs osteogenic differentiation in stem cells. Biomaterials Science 2017, 6: 189-199. PMID: 29189838, DOI: 10.1039/c7bm00733g.Peer-Reviewed Original ResearchConceptsStem cell osteogenic differentiationNanocomposite substrateCell osteogenic differentiationCell-imprinted substratesAtomic force microscopyWater contact angle measurementsOsteogenic differentiationNanoscale resolutionCultured stem cellsHydroxyapatite nanoparticlesContact angle measurementsDynamic mechanical thermal analysisForce microscopyStem cellsStem cell differentiationMechanical thermal analysisGene expression analysisElectron microscopyAngle measurementsChemical signalingExpression analysisOsteogenic differentiation capacityAlizarin red stainingChemical signalsCell differentiationIn-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering
Ghorbani F, Moradi L, Shadmehr M, Bonakdar S, Droodinia A, Safshekan F. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. Materials Science And Engineering C 2017, 81: 74-83. PMID: 28888019, DOI: 10.1016/j.msec.2017.04.150.Peer-Reviewed Original ResearchConceptsTracheal tissue engineeringTissue engineeringHybrid scaffoldsAdipose-derived mesenchymal stem cellsElectrospun polycaprolactone scaffoldsRabbit adipose-derived mesenchymal stem cellsPCL stentsTensile strengthPolycaprolactone scaffoldsPCL/Long tracheal stenosisCharacterization resultsSwelling ratioSynthetic scaffoldsBlue staining resultsSynthetic materialsAllogeneic aortasTracheal stenosisTracheal collapseCommon treatmentAlternative treatmentMesenchymal stem cellsGranulation formationAortaEngineeringRegeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study
Moradi L, Vasei M, Dehghan M, Majidi M, Mohajeri S, Bonakdar S. Regeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study. Biomaterials 2017, 126: 18-30. PMID: 28242519, DOI: 10.1016/j.biomaterials.2017.02.022.Peer-Reviewed Original Research
2016
An Investigation of Topics and Trends of Tracheal Replacement Studies Using Co-Occurrence Analysis
Ghorbani F, Feizabadi M, Farzanegan R, Vaziri E, Samani S, Lajevardi S, Moradi L, Shadmehr M. An Investigation of Topics and Trends of Tracheal Replacement Studies Using Co-Occurrence Analysis. Tissue Engineering Part B Reviews 2016, 23: 118-127. PMID: 27758155, DOI: 10.1089/ten.teb.2016.0254.Peer-Reviewed Original ResearchEpidermal growth factor receptor targeting alters gene expression and restores the adhesion function of cancerous cells as measured by single cell force spectroscopy
Azadi S, Tafazzoli-Shadpour M, Omidvar R, Moradi L, Habibi-Anbouhi M. Epidermal growth factor receptor targeting alters gene expression and restores the adhesion function of cancerous cells as measured by single cell force spectroscopy. Molecular And Cellular Biochemistry 2016, 423: 129-139. PMID: 27696309, DOI: 10.1007/s11010-016-2831-x.Peer-Reviewed Original ResearchConceptsCell-cell adhesionE-cadherin expressionEpidermal growth factor receptorGrowth factor receptorAdhesion functionCell-cell adhesion forcesCell-cell adhesion functionSingle-cell force spectroscopyFactor receptorAlters gene expressionCell force spectroscopyE-cadherin geneTime PCR analysisBlockade of EGFRTreatment of cellsForce spectroscopy techniquesHuman epithelial cancer cell linesEpithelial cancer cell linesCancerous cellsCell mechanical propertiesEGFR activityGene expressionCell behaviorInhibition of metastasisCancer progression
2010
Ultrastructural Change of Cerebellum in Exposed Rats to 3mT Electromagnetic Field
Ozra A, Jafar S, Moradi L, Saki G. Ultrastructural Change of Cerebellum in Exposed Rats to 3mT Electromagnetic Field. Journal Of Biological Sciences 2010, 10: 526-530. DOI: 10.3923/jbs.2010.526.530.Peer-Reviewed Original ResearchPurkinje cellsEMF-exposed ratsUltrastructural changesCentral nervous systemAdult female Wister ratsMonths of ageFemale Wister ratsExperimental groupMean nuclear diameterVacuolization of cytoplasmFemale ratsWister ratsGroup 2Group 1Disappearance of cristaeLong-term exposureNervous systemRatsCerebellumElectron microscopic studyTissue samplesNuclear diameterUntreated controlsCondensation of nucleiMonths