2021
Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair
Abpeikar Z, Moradi L, Javdani M, Kargozar S, Soleimannejad M, Hasanzadeh E, Mirzaei S, Asadpour S. Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair. Cartilage 2021, 13: 1583s-1601s. PMID: 34340598, PMCID: PMC8804732, DOI: 10.1177/19476035211035418.Peer-Reviewed Original ResearchConceptsComposite scaffoldsSuitable mechanical propertiesSelf-healing capacityMechanical propertiesMechanical testsElectron microscopeInner avascular zoneAllogeneic adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsGood biocompatibilityMeniscus cartilageScaffoldsCarbodiimide hydrochlorideCartilage repairAntioxidant capacityNew Zealand rabbitsTotal antioxidant capacityBiocompatibilityMacroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assaysDetection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix
Ghorbani F, Ekhtiari M, Moeini Chaghervand B, Moradi L, Mohammadi B, Kajbafzadeh A. Detection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix. Cell And Tissue Banking 2021, 23: 119-128. PMID: 33909237, DOI: 10.1007/s10561-021-09921-z.Peer-Reviewed Original Research
2020
Stem Cells and Hydrogels for Liver Tissue Engineering: Synergistic Cure for Liver Regeneration
Nadi A, Moradi L, Ai J, Asadpour S. Stem Cells and Hydrogels for Liver Tissue Engineering: Synergistic Cure for Liver Regeneration. Stem Cell Reviews And Reports 2020, 16: 1092-1104. PMID: 33070256, DOI: 10.1007/s12015-020-10060-3.Peer-Reviewed Original ResearchCoronavirus disease 2019: A tissue engineering and regenerative medicine perspective
Shafiee A, Moradi L, Lim M, Brown J. Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective. Stem Cells Translational Medicine 2020, 10: 27-38. PMID: 32820868, PMCID: PMC7461291, DOI: 10.1002/sctm.20-0197.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeMesenchymal stem cellsCoronavirus infectionCOVID-19Significant unmet medical needRespiratory distress syndromeRecent clinical trialsMajority of deathsUnmet medical needNovel coronavirus diseaseDistress syndromeCurrent therapiesMSC therapyClinical trialsDisease progressionEffective treatmentTherapeutic benefitAntiviral agentsInfective diseasesTissue engineeringMedical needVaccine technologyCoronavirus diseaseInfectionMedicine perspectiveDelivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model
Alizadeh A, Moradi L, Katebi M, Ai J, Azami M, Moradveisi B, Ostad S. Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model. Journal Of Tissue Viability 2020, 29: 359-366. PMID: 32839065, DOI: 10.1016/j.jtv.2020.06.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryHuman adipose-derived mesenchymal stem cellsNerve growth factorSpinal cord regenerationCord regenerationGrowth factorBetter locomotor functionBetter therapeutic strategiesPositive control groupRat animal modelAdipose-derived mesenchymal stem cellsSCI treatmentSham groupSurgical interventionCord injuryLocomotor functionSCI siteTherapeutic strategiesAnimal modelsControl groupMesenchymal stem cellsHistological studyBeneficial effectsRats animalsOne weekEvaluation of different sterilization methods for decellularized kidney tissue
Moradi L, Mohammadi Jobania B, Jafarnezhad-Ansariha F, Ghorbani F, Esmaeil-Pour R, Majidi Zolbina M, Kajbafzadeh A. Evaluation of different sterilization methods for decellularized kidney tissue. Tissue And Cell 2020, 66: 101396. PMID: 32933719, DOI: 10.1016/j.tice.2020.101396.Peer-Reviewed Original Research
2019
Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis
Samiei N, Hosseini S, Maleki M, Moradi L, Joghataei M, Arabian M. Modulatory Role of SIRT1 and Resistin as Therapeutic Targets in Patients with Aortic Valve Stenosis. Archives Of Medical Research 2019, 50: 333-341. PMID: 31677538, DOI: 10.1016/j.arcmed.2019.10.001.Peer-Reviewed Original ResearchConceptsSilent information regulator 1Aortic valve stenosisPeripheral blood mononuclear cellsResistin levelsValve stenosisAS groupExpression of SIRT1Modulatory roleAortic valve replacementLevels of resistinBlood mononuclear cellsInformation regulator 1Effects of resveratrolAS preventionValve replacementPharmacological therapyMononuclear cellsResistin expressionSIRT1 expressionTargeted therapySIRT1 levelsTherapeutic effectHealthy subjectsNovel biomarkersTherapeutic target
2017
In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering
Ghorbani F, Moradi L, Shadmehr M, Bonakdar S, Droodinia A, Safshekan F. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. Materials Science And Engineering C 2017, 81: 74-83. PMID: 28888019, DOI: 10.1016/j.msec.2017.04.150.Peer-Reviewed Original ResearchConceptsTracheal tissue engineeringTissue engineeringHybrid scaffoldsAdipose-derived mesenchymal stem cellsElectrospun polycaprolactone scaffoldsRabbit adipose-derived mesenchymal stem cellsPCL stentsTensile strengthPolycaprolactone scaffoldsPCL/Long tracheal stenosisCharacterization resultsSwelling ratioSynthetic scaffoldsBlue staining resultsSynthetic materialsAllogeneic aortasTracheal stenosisTracheal collapseCommon treatmentAlternative treatmentMesenchymal stem cellsGranulation formationAortaEngineeringRegeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study
Moradi L, Vasei M, Dehghan M, Majidi M, Mohajeri S, Bonakdar S. Regeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study. Biomaterials 2017, 126: 18-30. PMID: 28242519, DOI: 10.1016/j.biomaterials.2017.02.022.Peer-Reviewed Original Research
2016
An Investigation of Topics and Trends of Tracheal Replacement Studies Using Co-Occurrence Analysis
Ghorbani F, Feizabadi M, Farzanegan R, Vaziri E, Samani S, Lajevardi S, Moradi L, Shadmehr M. An Investigation of Topics and Trends of Tracheal Replacement Studies Using Co-Occurrence Analysis. Tissue Engineering Part B Reviews 2016, 23: 118-127. PMID: 27758155, DOI: 10.1089/ten.teb.2016.0254.Peer-Reviewed Original Research
2008
The Study of Developmental Capacity of Vitrified Mouse Blastocysts in Different Straws after Transfer to Mouse Pseudo Pregnant
Saki G, Rahim F, Moradi L. The Study of Developmental Capacity of Vitrified Mouse Blastocysts in Different Straws after Transfer to Mouse Pseudo Pregnant. Pakistan Journal Of Biological Sciences 2008, 11: 1809-14. PMID: 18817221, DOI: 10.3923/pjbs.2008.1809.1814.Peer-Reviewed Original ResearchConceptsBirth rateConventional strawRe-expansion rateFemale NMRI micePregnant miceNMRI miceCervical dislocationUterine hornVitrification of blastocystsCPS groupSuper ovulationPregnancyMouse blastocystsPseudo-pregnant miceMiceReproductive technologiesMouse abdomenFresh blastocystsUntreated controlsDevelopmental capacityPre-implantation mammalian embryosBlastocystsM16 mediumGroupGonadotrophin