2021
Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair
Abpeikar Z, Moradi L, Javdani M, Kargozar S, Soleimannejad M, Hasanzadeh E, Mirzaei S, Asadpour S. Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair. Cartilage 2021, 13: 1583s-1601s. PMID: 34340598, PMCID: PMC8804732, DOI: 10.1177/19476035211035418.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAscorbic AcidFibroinsGelatinMeniscusPolyestersRabbitsTissue EngineeringTissue ScaffoldsConceptsComposite scaffoldsSuitable mechanical propertiesSelf-healing capacityMechanical propertiesMechanical testsElectron microscopeInner avascular zoneAllogeneic adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsGood biocompatibilityMeniscus cartilageScaffoldsCarbodiimide hydrochlorideCartilage repairAntioxidant capacityNew Zealand rabbitsTotal antioxidant capacityBiocompatibilityMacroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCartilage, ArticularGelatinMeniscusNanofibersPiroxicamPolyestersRabbitsTissue EngineeringTissue ScaffoldsConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assaysDetection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix
Ghorbani F, Ekhtiari M, Moeini Chaghervand B, Moradi L, Mohammadi B, Kajbafzadeh A. Detection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix. Cell And Tissue Banking 2021, 23: 119-128. PMID: 33909237, DOI: 10.1007/s10561-021-09921-z.Peer-Reviewed Original ResearchConceptsPerfusion-based method
2019
Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications
Asadpour S, Kargozar S, Moradi L, Ai A, Nosrati H, Ai J. Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications. International Journal Of Biological Macromolecules 2019, 154: 1285-1294. PMID: 31733251, DOI: 10.1016/j.ijbiomac.2019.11.003.Peer-Reviewed Original ResearchMeSH KeywordsBiocompatible MaterialsChitosanFibroinsGelatinMechanical PhenomenaPorosityTissue EngineeringTissue ScaffoldsWettabilityConceptsComposite scaffoldsTissue engineering applicationsSilk fibroinMechanical strengthEngineering applicationsFabricated composite scaffoldsNatural extra cellular matrixBiocompatibility of scaffoldsDifferent blending ratiosFreeze-drying techniqueSilk fibroin-chitosanGood interconnectivityTensile testsSuitable porositySurface wettabilityBlending ratioDegradation measurementsBombyx mori silkwormPore sizeChitosan-gelatinFibroinCell affinityDegradation rateExtra-cellular matrixWater uptake
2017
In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering
Ghorbani F, Moradi L, Shadmehr M, Bonakdar S, Droodinia A, Safshekan F. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. Materials Science And Engineering C 2017, 81: 74-83. PMID: 28888019, DOI: 10.1016/j.msec.2017.04.150.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCells, CulturedChondrocytesHumansPolyestersTissue EngineeringTissue ScaffoldsTracheaConceptsTracheal tissue engineeringTissue engineeringHybrid scaffoldsAdipose-derived mesenchymal stem cellsElectrospun polycaprolactone scaffoldsRabbit adipose-derived mesenchymal stem cellsPCL stentsTensile strengthPolycaprolactone scaffoldsPCL/Long tracheal stenosisCharacterization resultsSwelling ratioSynthetic scaffoldsBlue staining resultsSynthetic materialsAllogeneic aortasTracheal stenosisTracheal collapseCommon treatmentAlternative treatmentMesenchymal stem cellsGranulation formationAortaEngineeringRegeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study
Moradi L, Vasei M, Dehghan M, Majidi M, Mohajeri S, Bonakdar S. Regeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study. Biomaterials 2017, 126: 18-30. PMID: 28242519, DOI: 10.1016/j.biomaterials.2017.02.022.Peer-Reviewed Original Research