2021
Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair
Abpeikar Z, Moradi L, Javdani M, Kargozar S, Soleimannejad M, Hasanzadeh E, Mirzaei S, Asadpour S. Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair. Cartilage 2021, 13: 1583s-1601s. PMID: 34340598, PMCID: PMC8804732, DOI: 10.1177/19476035211035418.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAscorbic AcidFibroinsGelatinMeniscusPolyestersRabbitsTissue EngineeringTissue ScaffoldsConceptsComposite scaffoldsSuitable mechanical propertiesSelf-healing capacityMechanical propertiesMechanical testsElectron microscopeInner avascular zoneAllogeneic adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsGood biocompatibilityMeniscus cartilageScaffoldsCarbodiimide hydrochlorideCartilage repairAntioxidant capacityNew Zealand rabbitsTotal antioxidant capacityBiocompatibilityMacroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCartilage, ArticularGelatinMeniscusNanofibersPiroxicamPolyestersRabbitsTissue EngineeringTissue ScaffoldsConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assaysDetection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix
Ghorbani F, Ekhtiari M, Moeini Chaghervand B, Moradi L, Mohammadi B, Kajbafzadeh A. Detection of the residual concentration of sodium dodecyl sulfate in the decellularized whole rabbit kidney extracellular matrix. Cell And Tissue Banking 2021, 23: 119-128. PMID: 33909237, DOI: 10.1007/s10561-021-09921-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDetergentsExtracellular MatrixHEK293 CellsHumansKidneyPerfusionRabbitsSodium Dodecyl SulfateTissue EngineeringTissue ScaffoldsConceptsPerfusion-based method
2020
Stem Cells and Hydrogels for Liver Tissue Engineering: Synergistic Cure for Liver Regeneration
Nadi A, Moradi L, Ai J, Asadpour S. Stem Cells and Hydrogels for Liver Tissue Engineering: Synergistic Cure for Liver Regeneration. Stem Cell Reviews And Reports 2020, 16: 1092-1104. PMID: 33070256, DOI: 10.1007/s12015-020-10060-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsClinical Trials as TopicHumansHydrogelsLiverLiver RegenerationStem CellsTissue EngineeringCoronavirus disease 2019: A tissue engineering and regenerative medicine perspective
Shafiee A, Moradi L, Lim M, Brown J. Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective. Stem Cells Translational Medicine 2020, 10: 27-38. PMID: 32820868, PMCID: PMC7461291, DOI: 10.1002/sctm.20-0197.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell- and Tissue-Based TherapyCOVID-19HumansRegenerative MedicineRespiratory Distress SyndromeSARS-CoV-2Tissue EngineeringConceptsAcute respiratory distress syndromeMesenchymal stem cellsCoronavirus infectionCOVID-19Significant unmet medical needRespiratory distress syndromeRecent clinical trialsMajority of deathsUnmet medical needNovel coronavirus diseaseDistress syndromeCurrent therapiesMSC therapyClinical trialsDisease progressionEffective treatmentTherapeutic benefitAntiviral agentsInfective diseasesTissue engineeringMedical needVaccine technologyCoronavirus diseaseInfectionMedicine perspectiveCorneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface
Nosrati H, Abpeikar Z, Mahmoudian Z, Zafari M, Majidi J, Alizadeh A, Moradi L, Asadpour S. Corneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface. Regenerative Medicine 2020, 15: 2029-2044. PMID: 33169642, DOI: 10.2217/rme-2019-0055.Peer-Reviewed Original ResearchMeSH KeywordsCorneaCorneal DiseasesEpithelium, CornealHumansProstheses and ImplantsRegenerationTissue EngineeringConceptsNative tissue microenvironmentCorneal tissue engineeringTissue engineeringCorneal regenerationCurrent clinical techniquesCell-based approachesRegenerative strategiesPromising approachBiological propertiesCorneal replacementRecent advancesCorneal transplantationCorneal diseaseSevere casesCornea donorsCorneal implantsCorneal surfaceInfection transmissionCorneal implantationClinical techniquesRegenerationBiomaterialsDifferent cell typesTissue microenvironmentNew approach
2019
Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications
Asadpour S, Kargozar S, Moradi L, Ai A, Nosrati H, Ai J. Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications. International Journal Of Biological Macromolecules 2019, 154: 1285-1294. PMID: 31733251, DOI: 10.1016/j.ijbiomac.2019.11.003.Peer-Reviewed Original ResearchMeSH KeywordsBiocompatible MaterialsChitosanFibroinsGelatinMechanical PhenomenaPorosityTissue EngineeringTissue ScaffoldsWettabilityConceptsComposite scaffoldsTissue engineering applicationsSilk fibroinMechanical strengthEngineering applicationsFabricated composite scaffoldsNatural extra cellular matrixBiocompatibility of scaffoldsDifferent blending ratiosFreeze-drying techniqueSilk fibroin-chitosanGood interconnectivityTensile testsSuitable porositySurface wettabilityBlending ratioDegradation measurementsBombyx mori silkwormPore sizeChitosan-gelatinFibroinCell affinityDegradation rateExtra-cellular matrixWater uptake
2017
In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering
Ghorbani F, Moradi L, Shadmehr M, Bonakdar S, Droodinia A, Safshekan F. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. Materials Science And Engineering C 2017, 81: 74-83. PMID: 28888019, DOI: 10.1016/j.msec.2017.04.150.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCells, CulturedChondrocytesHumansPolyestersTissue EngineeringTissue ScaffoldsTracheaConceptsTracheal tissue engineeringTissue engineeringHybrid scaffoldsAdipose-derived mesenchymal stem cellsElectrospun polycaprolactone scaffoldsRabbit adipose-derived mesenchymal stem cellsPCL stentsTensile strengthPolycaprolactone scaffoldsPCL/Long tracheal stenosisCharacterization resultsSwelling ratioSynthetic scaffoldsBlue staining resultsSynthetic materialsAllogeneic aortasTracheal stenosisTracheal collapseCommon treatmentAlternative treatmentMesenchymal stem cellsGranulation formationAortaEngineering
2016
An Investigation of Topics and Trends of Tracheal Replacement Studies Using Co-Occurrence Analysis
Ghorbani F, Feizabadi M, Farzanegan R, Vaziri E, Samani S, Lajevardi S, Moradi L, Shadmehr M. An Investigation of Topics and Trends of Tracheal Replacement Studies Using Co-Occurrence Analysis. Tissue Engineering Part B Reviews 2016, 23: 118-127. PMID: 27758155, DOI: 10.1089/ten.teb.2016.0254.Peer-Reviewed Original Research