2021
Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair
Abpeikar Z, Moradi L, Javdani M, Kargozar S, Soleimannejad M, Hasanzadeh E, Mirzaei S, Asadpour S. Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair. Cartilage 2021, 13: 1583s-1601s. PMID: 34340598, PMCID: PMC8804732, DOI: 10.1177/19476035211035418.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAscorbic AcidFibroinsGelatinMeniscusPolyestersRabbitsTissue EngineeringTissue ScaffoldsConceptsComposite scaffoldsSuitable mechanical propertiesSelf-healing capacityMechanical propertiesMechanical testsElectron microscopeInner avascular zoneAllogeneic adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsGood biocompatibilityMeniscus cartilageScaffoldsCarbodiimide hydrochlorideCartilage repairAntioxidant capacityNew Zealand rabbitsTotal antioxidant capacityBiocompatibilityMacroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assays
2017
In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering
Ghorbani F, Moradi L, Shadmehr M, Bonakdar S, Droodinia A, Safshekan F. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. Materials Science And Engineering C 2017, 81: 74-83. PMID: 28888019, DOI: 10.1016/j.msec.2017.04.150.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCells, CulturedChondrocytesHumansPolyestersTissue EngineeringTissue ScaffoldsTracheaConceptsTracheal tissue engineeringTissue engineeringHybrid scaffoldsAdipose-derived mesenchymal stem cellsElectrospun polycaprolactone scaffoldsRabbit adipose-derived mesenchymal stem cellsPCL stentsTensile strengthPolycaprolactone scaffoldsPCL/Long tracheal stenosisCharacterization resultsSwelling ratioSynthetic scaffoldsBlue staining resultsSynthetic materialsAllogeneic aortasTracheal stenosisTracheal collapseCommon treatmentAlternative treatmentMesenchymal stem cellsGranulation formationAortaEngineering