2021
Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assays
2017
An engineered cell-imprinted substrate directs osteogenic differentiation in stem cells
Kamguyan K, Katbab A, Mahmoudi M, Thormann E, Zajforoushan Moghaddam S, Moradi L, Bonakdar S. An engineered cell-imprinted substrate directs osteogenic differentiation in stem cells. Biomaterials Science 2017, 6: 189-199. PMID: 29189838, DOI: 10.1039/c7bm00733g.Peer-Reviewed Original ResearchConceptsStem cell osteogenic differentiationNanocomposite substrateCell osteogenic differentiationCell-imprinted substratesAtomic force microscopyWater contact angle measurementsOsteogenic differentiationNanoscale resolutionCultured stem cellsHydroxyapatite nanoparticlesContact angle measurementsDynamic mechanical thermal analysisForce microscopyStem cellsStem cell differentiationMechanical thermal analysisGene expression analysisElectron microscopyAngle measurementsChemical signalingExpression analysisOsteogenic differentiation capacityAlizarin red stainingChemical signalsCell differentiation