2021
Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assays
2020
Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective
Shafiee A, Moradi L, Lim M, Brown J. Coronavirus disease 2019: A tissue engineering and regenerative medicine perspective. Stem Cells Translational Medicine 2020, 10: 27-38. PMID: 32820868, PMCID: PMC7461291, DOI: 10.1002/sctm.20-0197.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeMesenchymal stem cellsCoronavirus infectionCOVID-19Significant unmet medical needRespiratory distress syndromeRecent clinical trialsMajority of deathsUnmet medical needNovel coronavirus diseaseDistress syndromeCurrent therapiesMSC therapyClinical trialsDisease progressionEffective treatmentTherapeutic benefitAntiviral agentsInfective diseasesTissue engineeringMedical needVaccine technologyCoronavirus diseaseInfectionMedicine perspectiveDelivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model
Alizadeh A, Moradi L, Katebi M, Ai J, Azami M, Moradveisi B, Ostad S. Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model. Journal Of Tissue Viability 2020, 29: 359-366. PMID: 32839065, DOI: 10.1016/j.jtv.2020.06.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryHuman adipose-derived mesenchymal stem cellsNerve growth factorSpinal cord regenerationCord regenerationGrowth factorBetter locomotor functionBetter therapeutic strategiesPositive control groupRat animal modelAdipose-derived mesenchymal stem cellsSCI treatmentSham groupSurgical interventionCord injuryLocomotor functionSCI siteTherapeutic strategiesAnimal modelsControl groupMesenchymal stem cellsHistological studyBeneficial effectsRats animalsOne week
2017
In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering
Ghorbani F, Moradi L, Shadmehr M, Bonakdar S, Droodinia A, Safshekan F. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. Materials Science And Engineering C 2017, 81: 74-83. PMID: 28888019, DOI: 10.1016/j.msec.2017.04.150.Peer-Reviewed Original ResearchConceptsTracheal tissue engineeringTissue engineeringHybrid scaffoldsAdipose-derived mesenchymal stem cellsElectrospun polycaprolactone scaffoldsRabbit adipose-derived mesenchymal stem cellsPCL stentsTensile strengthPolycaprolactone scaffoldsPCL/Long tracheal stenosisCharacterization resultsSwelling ratioSynthetic scaffoldsBlue staining resultsSynthetic materialsAllogeneic aortasTracheal stenosisTracheal collapseCommon treatmentAlternative treatmentMesenchymal stem cellsGranulation formationAortaEngineering