2021
Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair
Abpeikar Z, Moradi L, Javdani M, Kargozar S, Soleimannejad M, Hasanzadeh E, Mirzaei S, Asadpour S. Characterization of Macroporous Polycaprolactone/Silk Fibroin/Gelatin/Ascorbic Acid Composite Scaffolds and In Vivo Results in a Rabbit Model for Meniscus Cartilage Repair. Cartilage 2021, 13: 1583s-1601s. PMID: 34340598, PMCID: PMC8804732, DOI: 10.1177/19476035211035418.Peer-Reviewed Original ResearchConceptsComposite scaffoldsSuitable mechanical propertiesSelf-healing capacityMechanical propertiesMechanical testsElectron microscopeInner avascular zoneAllogeneic adipose-derived mesenchymal stem cellsAdipose-derived mesenchymal stem cellsGood biocompatibilityMeniscus cartilageScaffoldsCarbodiimide hydrochlorideCartilage repairAntioxidant capacityNew Zealand rabbitsTotal antioxidant capacityBiocompatibilityMacroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair
Abpeikar Z, Javdani M, Mirzaei S, Alizadeh A, Moradi L, Soleimannejad M, Bonakdar S, Asadpour S. Macroporous scaffold surface modified with biological macromolecules and piroxicam-loaded gelatin nanofibers toward meniscus cartilage repair. International Journal Of Biological Macromolecules 2021, 183: 1327-1345. PMID: 33932422, DOI: 10.1016/j.ijbiomac.2021.04.151.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stem cellsChondrocyte marker genesRabbit adipose-derived mesenchymal stem cellsHigh expression levelsNative meniscus tissueGelatin nanofibersMarker genesSurface-modified scaffoldsGene expressionCompressive Young's modulusMesenchymal stem cellsCell migrationDAPI stainingMeniscus tissue engineeringDegradation rateSelf-healing capacityStem cellsExpression levelsCell-seeded scaffoldsMechanical testsScaffold surfaceYoung's modulusPoor self-healing capacityBiological macromoleculesViability assays
2020
Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model
Alizadeh A, Moradi L, Katebi M, Ai J, Azami M, Moradveisi B, Ostad S. Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model. Journal Of Tissue Viability 2020, 29: 359-366. PMID: 32839065, DOI: 10.1016/j.jtv.2020.06.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryHuman adipose-derived mesenchymal stem cellsNerve growth factorSpinal cord regenerationCord regenerationGrowth factorBetter locomotor functionBetter therapeutic strategiesPositive control groupRat animal modelAdipose-derived mesenchymal stem cellsSCI treatmentSham groupSurgical interventionCord injuryLocomotor functionSCI siteTherapeutic strategiesAnimal modelsControl groupMesenchymal stem cellsHistological studyBeneficial effectsRats animalsOne weekEvaluation of different sterilization methods for decellularized kidney tissue
Moradi L, Mohammadi Jobania B, Jafarnezhad-Ansariha F, Ghorbani F, Esmaeil-Pour R, Majidi Zolbina M, Kajbafzadeh A. Evaluation of different sterilization methods for decellularized kidney tissue. Tissue And Cell 2020, 66: 101396. PMID: 32933719, DOI: 10.1016/j.tice.2020.101396.Peer-Reviewed Original ResearchConceptsAdipose-derived mesenchymal stem cellsKidney tissueKidney slicesPerfusion-based methodFungal culture tests
2017
In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering
Ghorbani F, Moradi L, Shadmehr M, Bonakdar S, Droodinia A, Safshekan F. In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering. Materials Science And Engineering C 2017, 81: 74-83. PMID: 28888019, DOI: 10.1016/j.msec.2017.04.150.Peer-Reviewed Original ResearchConceptsTracheal tissue engineeringTissue engineeringHybrid scaffoldsAdipose-derived mesenchymal stem cellsElectrospun polycaprolactone scaffoldsRabbit adipose-derived mesenchymal stem cellsPCL stentsTensile strengthPolycaprolactone scaffoldsPCL/Long tracheal stenosisCharacterization resultsSwelling ratioSynthetic scaffoldsBlue staining resultsSynthetic materialsAllogeneic aortasTracheal stenosisTracheal collapseCommon treatmentAlternative treatmentMesenchymal stem cellsGranulation formationAortaEngineering