2024
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramAssociation between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat areaHousehold air pollution and risk of pulmonary tuberculosis in HIV-Infected adults
Katoto P, Bihehe D, Brand A, Mushi R, Kusinza A, Alwood B, van Zyl-Smit R, Tamuzi J, Sam-Agudu N, Yotebieng M, Metcalfe J, Theron G, Godri Pollitt K, Lesosky M, Vanoirbeek J, Mortimer K, Nawrot T, Nemery B, Nachega J. Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults. Environmental Health 2024, 23: 6. PMID: 38233832, PMCID: PMC10792790, DOI: 10.1186/s12940-023-01044-0.Peer-Reviewed Original ResearchConceptsRisk of pulmonary tuberculosisPulmonary tuberculosisHousehold air pollutionHIV infectionTB-HIV coinfectionHIV-infected adultsAssociated with increased riskCase-control studyMultivariate logistic regressionHAP exposureDose-dependentlyPersonal CO exposuresPersonal carbon monoxidePTB riskLowest quintileCo-exposureHighest quintileBackgroundIn low-Logistic regressionRandom sub-sampleEffective interventionsHIVTuberculosisAir pollutionEastern Democratic Republic of Congo
2022
Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study
Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. The Science Of The Total Environment 2022, 854: 158716. PMID: 36113793, DOI: 10.1016/j.scitotenv.2022.158716.Peer-Reviewed Original Research
2021
Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults
Weichenthal S, Lavigne E, Traub A, Umbrio D, You H, Pollitt K, Shin T, Kulka R, Stieb DM, Korsiak J, Jessiman B, Brook JR, Hatzopoulou M, Evans G, Burnett RT. Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults. Environmental Health Perspectives 2021, 129: 107005. PMID: 34644144, PMCID: PMC8513754, DOI: 10.1289/ehp9449.Peer-Reviewed Original ResearchConceptsAcute cardiovascular eventsCardiovascular eventsCase-crossover studyOdds ratioConditional logistic regression modelsFine particulate air pollutionLogistic regression modelsParticulate air pollutionStrength of associationCanadian adultsPopulation health risksObserved associationsRecent evidenceWeak associationOxidative potentialHealth impactsMenAssociationHealth risksMedian valueRegression modelsInfluence associationsAssociated health impactsSimilar patternOutdoor PM2.5Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community
Katoto PDMC, Kayembe-Kitenge T, Pollitt KJG, Martens DS, Ghosh M, Nachega JB, Nemery B, Nawrot TS. Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community. Scientific Reports 2021, 11: 4031. PMID: 33597559, PMCID: PMC7889934, DOI: 10.1038/s41598-021-83281-2.Peer-Reviewed Original ResearchConceptsTreatment outcomesPTB patientsTelomere lengthActive pulmonary tuberculosis patientsMtDNA contentOutpatient TB clinicSuccessful TB treatmentProspective cohort studyPulmonary tuberculosis patientsTime of diagnosisOutcome of treatmentBlood mtDNA contentRural Democratic RepublicPeripheral blood leukocytesShorter telomere lengthLonger telomere lengthRelative telomere lengthHIV coinfectionTB clinicCohort studyPulmonary tuberculosisTB treatmentTuberculosis patientsPTB outcomesBlood leukocytes
2018
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study
Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environment International 2018, 121: 1331-1340. PMID: 30420132, PMCID: PMC6396878, DOI: 10.1016/j.envint.2018.10.055.Peer-Reviewed Original ResearchConceptsUbiquitin C-terminal hydrolase L1Vascular endothelium growth factorBiomarker levelsPost exposureSystemic inflammationOxidative stressNeural biomarkersS100 calcium-binding protein BCalcium-binding protein BNeural functionHealthy non-smoking volunteersConcentrated ambient PMAssessment of biomarkersNon-smoking volunteersStress marker cortisolAmbient PMUrinary malondialdehydeUrinary biomarkersUrinary cortisolInterleukin-6Mixed regression modelsVanillylmandelic acidInflammationMean concentrationGrowth factor
2017
Biomonitoring-based exposure assessment of benzene, toluene, ethylbenzene and xylene among workers at petroleum distribution facilities
Heibati B, Pollitt K, Charati JY, Ducatman A, Shokrzadeh M, Karimi A, Mohammadyan M. Biomonitoring-based exposure assessment of benzene, toluene, ethylbenzene and xylene among workers at petroleum distribution facilities. Ecotoxicology And Environmental Safety 2017, 149: 19-25. PMID: 29145162, DOI: 10.1016/j.ecoenv.2017.10.070.Peer-Reviewed Original ResearchConceptsGas chromatography-mass spectrometrySolid-phase microextractionChromatography-mass spectrometryVolatile organic compoundsOrganic compoundsPpb tolueneMass spectrometryPassive samplersPersonal passive samplersConcentrations of BTEXPpb benzeneBenzeneBTEX compoundsTolueneUrinary BTEX levelsOil distribution companyPersonal exposureXylenePersonal air exposuresBTEXCompoundsEthylbenzeneOccupational health concernAir exposureRapid method
2016
Fine Particulate Matter and Emergency Room Visits for Respiratory Illness. Effect Modification by Oxidative Potential
Weichenthal SA, Lavigne E, Evans GJ, Pollitt K, Burnett RT. Fine Particulate Matter and Emergency Room Visits for Respiratory Illness. Effect Modification by Oxidative Potential. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 577-86. PMID: 26963193, DOI: 10.1164/rccm.201512-2434oc.Peer-Reviewed Original ResearchConceptsEmergency room visitsAcute respiratory morbidityRespiratory illnessRoom visitsImpact of PM2.5Respiratory morbidityChronic obstructive pulmonary diseaseAcute respiratory illnessObstructive pulmonary diseaseFine particulate air pollutionCases of asthmaConditional logistic regressionCase-crossover studyParticulate air pollutionRespiratory outcomesPulmonary diseaseEmergency roomEffect modificationRespiratory tractDaily air pollution dataInterquartile changeTime-varying covariatesOxidative burdenIllnessLogistic regressionTrace metal exposure is associated with increased exhaled nitric oxide in asthmatic children
Godri Pollitt KJ, Maikawa CL, Wheeler AJ, Weichenthal S, Dobbin NA, Liu L, Goldberg MS. Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children. Environmental Health 2016, 15: 94. PMID: 27586245, PMCID: PMC5009709, DOI: 10.1186/s12940-016-0173-5.Peer-Reviewed Original ResearchConceptsAsthmatic childrenIQR increaseNitric oxideEmergency room visitsExacerbation of symptomsPersonal daily exposureAcute health effectsResultsA positive associationElevated FeNOFeNO responseAirway inflammationRoom visitsMarker of trafficDaily exposureAsthma experienceConsecutive daysFeNOChildren's exposureHealth effectsPersonal samplesChildrenPositive associationExposureFine particulate matterAmbient PM2.5
2015
Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC)
Weichenthal S, Crouse DL, Pinault L, Godri-Pollitt K, Lavigne E, Evans G, van Donkelaar A, Martin RV, Burnett RT. Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC). Environmental Research 2015, 146: 92-99. PMID: 26745732, DOI: 10.1016/j.envres.2015.12.013.Peer-Reviewed Original ResearchConceptsCause-specific mortalityFine particulate air pollutionOxidative burdenParticulate air pollutionHazard ratioLung cancer hazard ratiosLong-term mortality riskCox proportional hazards modelCanadian Census HealthCancer hazard ratioLung cancer mortalityRisk of mortalityProportional hazards modelRespiratory tract lining fluidCanadian Long Form CensusEnvironment CohortSynthetic respiratory tract lining fluidCancer mortalityLung cancerLining fluidMortality riskHazards modelIndividual-level covariatesInterquartile changeLong-form census