2024
A deployable film method to enable replicable sampling of low-abundance environmental microbiomes
Mankiewicz Ledins P, Lin E, Bhattacharya C, Pollitt K, Dyson A, Hénaff E. A deployable film method to enable replicable sampling of low-abundance environmental microbiomes. Scientific Reports 2024, 14: 23857. PMID: 39394219, PMCID: PMC11470061, DOI: 10.1038/s41598-024-72341-y.Peer-Reviewed Original ResearchConceptsHuman healthPotential human health impactsHuman health impactsNegative long-term impactEnvironmental microbiomesTime indoorsEnvironmental nucleic acidsExposure studiesSequencing-based analysisChronic exposureHealth impactsHigher DNA yieldLong-term impactLow abundanceMicrobiome abundanceIndoor microbiome exposureSamplerMicrobiome samplesAbundanceIndoor microbiomeDNA yieldExtraction kitMicrobiomeSampling strategyGlobal populationExposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramAssociation between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat areaHousehold air pollution and risk of pulmonary tuberculosis in HIV-Infected adults
Katoto P, Bihehe D, Brand A, Mushi R, Kusinza A, Alwood B, van Zyl-Smit R, Tamuzi J, Sam-Agudu N, Yotebieng M, Metcalfe J, Theron G, Godri Pollitt K, Lesosky M, Vanoirbeek J, Mortimer K, Nawrot T, Nemery B, Nachega J. Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults. Environmental Health 2024, 23: 6. PMID: 38233832, PMCID: PMC10792790, DOI: 10.1186/s12940-023-01044-0.Peer-Reviewed Original ResearchConceptsRisk of pulmonary tuberculosisPulmonary tuberculosisHousehold air pollutionHIV infectionTB-HIV coinfectionHIV-infected adultsAssociated with increased riskCase-control studyMultivariate logistic regressionHAP exposureDose-dependentlyPersonal CO exposuresPersonal carbon monoxidePTB riskLowest quintileCo-exposureHighest quintileBackgroundIn low-Logistic regressionRandom sub-sampleEffective interventionsHIVTuberculosisAir pollutionEastern Democratic Republic of CongoAssessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface
Upadhyay S, Rahman M, Rinaldi S, Koelmel J, Lin E, Mahesh P, Beckers J, Johanson G, Pollitt K, Palmberg L, Irmler M, Ganguly K. Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface. Respiratory Research 2024, 25: 49. PMID: 38245732, PMCID: PMC10799428, DOI: 10.1186/s12931-024-02686-5.Peer-Reviewed Original ResearchConceptsWood smokeBiomass fuel burningHuman primary bronchial epithelial cellsSecretion levels of proinflammatory cytokinesLevels of proinflammatory cytokinesPrimary bronchial epithelial cellsTumor necrosis factor-aAir-liquid interfacePrimary ciliary dyskinesiaHousehold air pollutionHighest increased riskBackgroundChronic obstructive pulmonary diseaseBronchial epithelial cellsChronic respiratory disordersPassive samplingToxicological end pointsAssociated with COPDExposed to WSObstructive pulmonary diseaseTobacco smoke exposureAir pollutionWS exposureExposure induced changesPulmonary toxicityAcute phase response
2023
Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids
Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Pollitt K, Khan S, Johnson C. Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environmental Science And Technology 2023, 57: 21016-21028. PMID: 38064429, DOI: 10.1021/acs.est.3c04844.Peer-Reviewed Original ResearchConceptsColorectal cancerFatty acid β-oxidationCell linesSW48 cell linesSynthesis of proteinsProgression of CRCMigration phenotypeCRC cell linesEpithelial-mesenchymal transitionThree-dimensional spheroidsMetabolic pathwaysN-cadherinΒ-oxidationMechanism of actionNovel insightsE-cadherinBiological techniquesPromotes MigrationColorectal cancer spheroidsMigration assaysMetabolic profilingKRAS G12APerfluorooctanoic acidPersistent environmental contaminantsMetabolic profileDaily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada
Weichenthal S, Lavigne E, You H, Pollitt K, Shin T, Kulka R, Stieb D, Hatzopoulou M, Evans G, Burnett R. Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada. Epidemiology 2023, 34: 897-905. PMID: 37732880, DOI: 10.1097/ede.0000000000001651.Peer-Reviewed Original ResearchConceptsIschaemic heart disease eventsHeart disease eventsAcute cardiovascular eventsCardiovascular eventsDisease eventsOdds ratioPotential time-varying confoundersAcute cardiovascular effectsFine particulate air pollutionCase-crossover studyOutdoor fine particulate air pollutionHealth impactsCardiovascular health impactsParticulate air pollutionCardiovascular effectsHighest tertileTime-varying confoundersOlder subjectsHospitalizationObserved associationsOxidative stressOxidative potentialPM2.5 oxidative potentialMonthsAssociationPer- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryNon-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
Manz K, Feerick A, Braun J, Feng Y, Hall A, Koelmel J, Manzano C, Newton S, Pennell K, Place B, Godri Pollitt K, Prasse C, Young J. Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 524-536. PMID: 37380877, PMCID: PMC10403360, DOI: 10.1038/s41370-023-00574-6.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryNon-targeted analysisExposure mediaChemical spaceSoils/sedimentsMass spectrometryPolyfluoroalkyl substancesSemi-volatile organic compoundsChemical exposomePolyaromatic hydrocarbonsLiquid chromatographyEnvironmental mediaOrganic compoundsGC-HRMSHuman exposureLC-HRMSAnalytical platformConsumer productsChemical exposureSedimentsPesticidesEnvironmental chemicalsChemicalsExposure sourcesSpectrometryAssessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts
Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt K. Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts. The Science Of The Total Environment 2023, 892: 164681. PMID: 37302586, DOI: 10.1016/j.scitotenv.2023.164681.Peer-Reviewed Original ResearchAdequacy of stationary measurements as proxies for residential personal exposure to gaseous and particle air pollutants
González Serrano V, Lin E, Godri Pollitt K, Licina D. Adequacy of stationary measurements as proxies for residential personal exposure to gaseous and particle air pollutants. Environmental Research 2023, 231: 116197. PMID: 37224948, DOI: 10.1016/j.envres.2023.116197.Peer-Reviewed Original ResearchConceptsVolatile organic compoundsOrganic compoundsTotal volatile organic compoundsPassive samplersSingle COCompoundsCOPollutantsCarbon dioxideStationary samplesEnvironmental monitorsReal-time sensorsSVOCsParticlesHigh concentrationsPersonal exposure monitorsAirborne pollutantsInhalation exposure assessmentAir quality monitoringDioxideAir pollutantsParticle number concentrationConcentrationSamplerParticle pollutantsNovel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots
Koelmel J, Lin E, Parry E, Stelben P, Rennie E, Godri Pollitt K. Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots. The Science Of The Total Environment 2023, 883: 163579. PMID: 37100129, PMCID: PMC10247435, DOI: 10.1016/j.scitotenv.2023.163579.Peer-Reviewed Original ResearchConceptsBlood spotsNovel perfluoroalkyl substancesHuman bloodVenous blood drawBlood spot cardsBlood spot samplesPerfluoroalkyl substancesPrenatal exposureBlood drawEnvironmental epidemiology studiesEpidemiology studiesFalse negative rateBloodLow false negative rateInvasive collection techniquesWhole bloodVulnerable populationsLiquid chromatography-high resolution tandem mass spectrometryUnderstanding of exposureSpot samplesSpot cardsHigh-resolution tandem mass spectrometryExposurePerfluoroalkyl ether carboxylic acidsScreeningTrace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples
Lin E, Nason S, Zhong A, Fortner J, Godri Pollitt K. Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples. The Science Of The Total Environment 2023, 883: 163530. PMID: 37094673, PMCID: PMC10248884, DOI: 10.1016/j.scitotenv.2023.163530.Peer-Reviewed Original ResearchConceptsPolyfluoroalkyl substancesLiquid chromatography-high resolution mass spectrometryResolution mass spectrometryWater-repellent propertiesVenous blood samplesBlood samplesTrace levelsTrace analysisMass spectrometryWhole blood samplesChemical analysisAlkyl substancesHealthy adultsMan-made chemicalsAdverse health outcomesAnalytical methodBlank correctionHousehold productsHealth outcomesPFAS exposureInvasive methodBlood collectionBlood spotsCritical windowEnvironmental exposuresAssociation between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study
Ding E, Deng F, Fang J, Li T, Hou M, Liu J, Miao K, Yan W, Fang K, Shi W, Fu Y, Liu Y, Dong H, Dong L, Ding C, Liu X, Pollitt K, Ji J, Shi Y, Cai Y, Tang S, Shi X. Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60–69 Years of Age: Evidence from the China BAPE Study. Environmental Health Perspectives 2023, 131: 047009. PMID: 37042841, PMCID: PMC10094192, DOI: 10.1289/ehp11896.Peer-Reviewed Original ResearchConceptsYears of ageOPE exposureAdults 60OPE metabolitesCommon endocrine-disrupting chemicalsChina BAPE studySubsequent key eventsType 2 diabetesExposure reduction strategiesAdverse outcome pathwaysDiabetogenic effectInsulin resistanceUrine metabolomeElevated riskEster exposureParticipants 60Endocrine-disrupting chemicalsBlood transcriptomeAdverse effectsGlycometabolic disordersBiological etiologyAgeT2DMulti-omics analysisMarkersWearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions
Okeme J, Koelmel J, Johnson E, Lin E, Gao D, Pollitt K. Wearable Passive Samplers for Assessing Environmental Exposure to Organic Chemicals: Current Approaches and Future Directions. Current Environmental Health Reports 2023, 10: 84-98. PMID: 36821032, DOI: 10.1007/s40572-023-00392-w.Peer-Reviewed Original ResearchConceptsPassive samplersOrganic chemicalsExposure assessmentHigh-throughput chemical analysisSemi-volatile organic chemicalsComplex mixturesChemical analysisEnvironmental health researchEnvironmental contaminantsPopulation scaleMonitoring approachActive air samplingQuantitative exposure assessmentEvaluation of exposureCompositional diversityAnalytical challengesHundreds of chemicalsPersonal exposurePopulation levelExposure estimatesSamplerActive samplersEnvironmental chemicalsContaminantsDynamic mixturePaired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2022
Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential.
Korsiak J, Lavigne E, You H, Pollitt K, Kulka R, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1370-1378. PMID: 35802828, DOI: 10.1164/rccm.202205-0896oc.Peer-Reviewed Original ResearchConceptsRespiratory hospitalizationsConditional logistic regression modelsPediatric respiratory hospitalizationsFine particulate air pollutionCase-crossover studyLogistic regression modelsParticulate air pollutionOxidant gasesRespiratory healthEffect modificationOdds ratioHospitalizationParticle oxidative potentialStrong associationConfidence intervalsOxidative potentialMedianPositive associationChildrenAssociationMedian valueRegression modelsFine particulate matterOutdoor fine particlesAir pollutionPersonal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches
Shi W, Gao X, Cao Y, Chen Y, Cui Q, Deng F, Yang B, Lin E, Fang J, Li T, Tang S, Godri Pollitt K, Shi X. Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches. Environment International 2022, 170: 107614. PMID: 36375280, DOI: 10.1016/j.envint.2022.107614.Peer-Reviewed Original ResearchConceptsEpigenetic ageing biomarkersPolycyclic aromatic hydrocarbonsOrganic chemical contaminantsVolatile organic compoundsElderly individualsChemical exposureAge-related adverse effectsBayesian kernel machine regression (BKMR) modelsOrganic compoundsAging biomarkersChinese elderly individualsOrganic chemicalsHealthy elderly peopleLinear mixed-effects regression modelsHealthy elderly individualsAirborne chemical exposuresQuantile sum (WQS) regressionPassive samplersNitroaromaticsMixed effects regression modelsEpigenetic biomarkersChemical contaminantsPersonal chemical exposureChlorinated hydrocarbonsChemical mixturesUnequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA
Kodros J, Bell M, Dominici F, L’Orange C, Godri Pollitt K, Weichenthal S, Wu X, Volckens J. Unequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA. Nature Communications 2022, 13: 6329. PMID: 36319637, PMCID: PMC9626599, DOI: 10.1038/s41467-022-33372-z.Peer-Reviewed Original ResearchLong-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential
Toyib O, Lavigne E, Traub A, Umbrio D, You H, Ripley S, Pollitt K, Shin T, Kulka R, Jessiman B, Tjepkema M, Martin R, Stieb DM, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Long-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential. Epidemiology 2022, 33: 767-776. PMID: 36165987, PMCID: PMC9531968, DOI: 10.1097/ede.0000000000001538.Peer-Reviewed Original ResearchConceptsLong-term exposureOxidative stressFine particulate air pollutionProportional hazards modelAir pollution health effectsHealth impactsObserved health impactsParticulate air pollutionCohort studyMortality outcomesOxidant gasesEffect modificationInterquartile increaseHazards modelAdverse health impactsNonaccidental mortalityGSH levelsHealth effectsMortalityLand use regression modelsOxidative potentialMedianRegression modelsExposurePM 2.5