2024
Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns
Dye C, Alschuler D, Wu H, Duarte C, Monk C, Belsky D, Lee S, O’Donnell K, Baccarelli A, Scorza P. Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns. JAMA Network Open 2024, 7: e2427063. PMID: 39120899, PMCID: PMC11316241, DOI: 10.1001/jamanetworkopen.2024.27063.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesEdinburgh Postnatal Depression ScaleAccessible Resource for Integrated Epigenomics StudiesEpigenetic age accelerationGestational age accelerationAssociated with epigenetic agingAvon Longitudinal Study of ParentsLongitudinal Study of ParentsPostnatal Depression ScalePrimary outcomeChildhood experiencesAvon Longitudinal StudyEpigenetic ageStudy of ParentsAge accelerationHigher ACE scoresCross-sectional studyEpigenetic clocksMother-offspring dyadsDepression ScaleHealth districtMother-child dyadsDNA methylation–based epigenetic clocksInvestigate depression
2023
Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents
Kee M, Cremaschi A, De Iorio M, Chen H, Montreuil T, Nguyen T, Côté S, O’Donnell K, Giesbrecht G, Letourneau N, Chan S, Meaney M. Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents. JAMA Network Open 2023, 6: e2339942. PMID: 37883082, PMCID: PMC10603499, DOI: 10.1001/jamanetworkopen.2023.39942.Peer-Reviewed Original ResearchConceptsSelf-reported depressive symptomsMaternal depressive symptomsDepressive symptomsPerinatal periodPostnatal periodEdinburgh Postnatal Depression ScalePostnatal Depression ScaleEpidemiological Studies DepressionHealth policy guidelinesPublic health initiativesGroups of mothersCohort studyObservational cohortProspective cohortPregnancy influencesReferral guidelinesMultiple time pointsDepression ScaleMAIN OUTCOMEPregnancyPostnatal onsetStudies DepressionHealth initiativesTimely interventionCohortEarly intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial
Milgrom J, Hirshler Y, Holt C, Skouteris H, Galbally M, East C, Glover V, Reece J, O’Donnell K, Walker S, Malloy S, Gemmill A. Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial. BMC Psychology 2023, 11: 222. PMID: 37542332, PMCID: PMC10401817, DOI: 10.1186/s40359-023-01244-w.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChild Behavior ChecklistChild outcomesBehavioral developmentMaternal depressionAntenatal depression treatmentChild developmental outcomesRevised Infant Behavior QuestionnaireInfant Behavior QuestionnaireActive psychological treatmentsMother-infant interactionAntenatal depressionAdditional secondary outcome measuresMonths of ageAdverse child outcomesOutcome measuresPsychological treatmentCBT programMental health disordersBehavioral therapyAnxiety symptomsBehavior ChecklistBehavioral problemsExternalising problemsInternalising scalesMaternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic riskTemperature variability and birthweight: Epidemiological evidence from Africa
Wang P, O'Donnell K, Warren J, Dubrow R, Chen K. Temperature variability and birthweight: Epidemiological evidence from Africa. Environment International 2023, 173: 107792. PMID: 36841185, DOI: 10.1016/j.envint.2023.107792.Peer-Reviewed Original ResearchFetal Programming and Public Policy
Glover V, O'Connor T, O'Donnell K. Fetal Programming and Public Policy. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: 618-620. PMID: 36608741, DOI: 10.1016/j.jaac.2022.11.010.Peer-Reviewed Original Research
2022
The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort
Pagès N, Gorgui J, Wang C, Wang X, Zhao JP, Tchuente V, Lacasse A, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O'Donnell KJ, Eltonsy S, Chateau D, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V, Bérard A. The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort. International Journal Of Environmental Research And Public Health 2022, 19: 12386. PMID: 36231687, PMCID: PMC9566261, DOI: 10.3390/ijerph191912386.Peer-Reviewed Original ResearchConceptsMaternal mental healthMental healthMean GAD-7 scorePregnant personsGAD-7 scoresNon-pandemic periodMental health assessmentCanada 2Public health policyLevel of depressionDepressive scoresMaternal depressionChinese cohortEDPS scoreCOVID-19 public health policiesCOVID-19 experienceHealth policyCohortSociodemographic variablesSelf-reported dataConception cohortsHealth assessmentCOVID-19COVID-19 pandemicScoresMaternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood
O’Connor T, Ciesla AA, Sefair AV, Thornburg LL, Brown AS, Glover V, O’Donnell K. Maternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood. Journal Of Psychopathology And Clinical Science 2022, 131: 422-434. PMID: 35238594, PMCID: PMC9069845, DOI: 10.1037/abn0000746.Peer-Reviewed Original ResearchConceptsChild neurodevelopmentSelf-report questionnairesPrenatal maternal anxietyPrediction of symptomsAttention problemsMiddle childhoodCommunication problemsAnxiety symptomsPerson testingAvon Longitudinal StudyEmotional symptomsPrenatal anxietyPrenatal riskPrenatal maternal infectionMaternal anxietyAnxietyMental healthLongitudinal studyPrenatal infectionSeparate linesLine of studyLarge prospective longitudinal cohort studyProspective longitudinal cohort studyChild CohortNeurodevelopmentThe COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation
Bérard A, Gorgui J, Tchuente V, Lacasse A, Gomez YH, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O’Donnell K, Eltonsy S, Chateau D, Zhao JP, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V. The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation. International Journal Of Environmental Research And Public Health 2022, 19: 2926. PMID: 35270623, PMCID: PMC8910614, DOI: 10.3390/ijerph19052926.Peer-Reviewed Original ResearchMeSH KeywordsChildCOVID-19FemaleHumansInfant, NewbornMental HealthPandemicsPregnancyPremature BirthSARS-CoV-2ConceptsMaternal mental healthTrimester of gestationMental healthMaternal depressionPregnancy statusMultivariate logistic regression modelDepressive symptom scoresPost-partum periodSevere maternal depressionCOVID-19 pandemicMental health measuresLogistic regression modelsAnxiety/stressPreterm birthSymptom scoresPregnant womenSevere depressionMaternal anxietyHealth measuresPregnant personsSignificant predictorsSociodemographic indicatorsTrimesterPregnancyCognitive problems
2021
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnxietyChildDNA MethylationEpigenesis, GeneticEpigenomicsFemaleHumansMalePregnancyConceptsPrenatal maternal anxietyFetal originEpigenetic age accelerationMaternal anxietyAge accelerationPrenatal anxietyMental healthPrenatal maternal mental healthMaternal mental healthYears of ageGenetic risk factorsMonths of ageMental health supportMaternal prenatal anxietyRisk factorsLongitudinal cohortPrenatal adversityPregnant individualsLarge effect sizesLongitudinal assessmentHealth supportEffective mental health supportCohortPrenatal environmentLate childhood
2020
Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder
Chen LM, Tollenaar MS, Dass S, Bouvette-Turcot AA, Pokhvisneva I, Gaudreau H, Parent C, Diorio J, McEwen LM, MacIsaac JL, Kobor MS, Beijers R, de Weerth C, Silveira PP, Karama S, Meaney MJ, O'Donnell KJ. Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder. Development And Psychopathology 2020, 32: 1810-1821. PMID: 33427178, DOI: 10.1017/s0954579420001418.Peer-Reviewed Original ResearchConceptsMaternal antenatal depressionAttention-deficit/hyperactivity disorderAntenatal depressionChild mental healthPolygenic risk scoresMental healthHyperactivity disorderChild mental health symptomsMental health symptomsConsiderable inter-individual variationConventional polygenic risk scoresMaternal depressionRisk scoreHealth symptomsReplication cohortSynaptic functionGenomic riskChild genetic variationInter-individual variationNeuronal developmentSimilar findingsDepressionSingle nucleotide polymorphismsDevelopmental originsBehavioral problems
2019
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Czamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O’Donnell K, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ, Räikkönen K, Binder E. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications 2019, 10: 2548. PMID: 31186427, PMCID: PMC6559955, DOI: 10.1038/s41467-019-10461-0.Peer-Reviewed Original ResearchConceptsDNA methylationEnvironmental factorsCellular functionsEpigenetic processesCord blood DNA methylationBlood DNA methylationMethylationGenetic variantsGenetic contributionIntegrated analysisPrenatal environmental factorsComplex disorderGenetic influencesGxE modelsGenotypesGWASRelative contributionGxEIndependent cohortCpGDisease riskEnrichmentVariantsDynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
Toepfer P, O'Donnell KJ, Entringer S, Garg E, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness. Psychoneuroendocrinology 2019, 103: 156-162. PMID: 30690225, PMCID: PMC6554513, DOI: 10.1016/j.psyneuen.2019.01.013.Peer-Reviewed Original ResearchConceptsLate pregnancyMaternal behaviorMonths postpartumEarly postnatal developmentNovel potential biomarkersRace/ethnicityPregnancy inducesPeripheral bloodPregnancyMother-child dyadsPostnatal maternal behaviourPostnatal developmentPotential biomarkersSteroid hormonesDNA methylationSocioeconomic statusWhole bloodPromoter DNA methylationMother-child interactionPostpartumBloodDNA methylation changesOxytocinDNAm trajectoriesMaternal intrusiveness
2018
Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years
Milgrom J, Holt CJ, Bleker LS, Holt C, Ross J, Ericksen J, Glover V, O’Donnell K, de Rooij SR, Gemmill AW. Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years. Journal Of Developmental Origins Of Health And Disease 2018, 10: 221-231. PMID: 30303063, DOI: 10.1017/s2040174418000739.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyBehavior Rating ScaleChild BehaviorChild DevelopmentChild, PreschoolCognitive Behavioral TherapyDepressionFemaleFollow-Up StudiesHumansIntelligence TestsLongitudinal StudiesMaleMothersParent-Child RelationsPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsRandomized Controlled Trials as TopicSeverity of Illness IndexTreatment OutcomeConceptsChild Behavior ChecklistParenting Stress IndexNeurodevelopmental outcomesChild developmentHigher CBCLIntervention effectsAntenatal depression treatmentMaternal antenatal depressionAdverse neurodevelopmental outcomesInfant neurodevelopmental outcomesAge 2Age 5Cognitive behavioral therapyWPPSI-III scoresNon-significant trendPSI total scoreAntenatal moodAntenatal depressionRoutine careDepression treatmentOriginal cohortTreatment allocationIntervention groupLong-term effectsEffective treatmentPolygenic differential susceptibility to prenatal adversity
Belsky J, Pokhvisneva I, Rema ASS, Broekman BFP, Pluess M, O'Donnell KJ, Meaney MJ, Silveira PP. Polygenic differential susceptibility to prenatal adversity. Development And Psychopathology 2018, 31: 439-441. PMID: 30081968, DOI: 10.1017/s0954579418000378.Peer-Reviewed Original ResearchPrenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective
Glover V, O'Donnell KJ, O'Connor TG, Fisher J. Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective. Development And Psychopathology 2018, 30: 843-854. PMID: 30068411, DOI: 10.1017/s095457941800038x.BooksMeSH KeywordsAnxiety DisordersBrainChildCross-Cultural ComparisonDepressive DisorderDeveloping CountriesFemaleFetal DevelopmentHumansHypothalamo-Hypophyseal SystemInfantMental DisordersPituitary-Adrenal SystemPregnancyPrenatal Exposure Delayed EffectsPsychopathologyPsychosocial DeprivationRisk FactorsSocial EnvironmentStress, PsychologicalConceptsPrenatal stressLater psychopathologyPregnancy-specific anxietyPrenatal maternal stressPrenatal stress altersAdrenal axisChild neurodevelopmentHigh-income countriesFetal programmingInfant deathMaternal stressGene-environment interactionsNutritional deficienciesMothers' stressDifferent ethnic groupsStress altersPsychopathologyBiological differencesEthnic groupsInterpersonal violenceAnxietyCaucasian samplesHigh levelsPregnancyCytokinesAssociations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study
Braithwaite EC, Hill J, Pickles A, Glover V, O’Donnell K, Sharp H. Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. Journal Of Developmental Origins Of Health And Disease 2018, 9: 425-431. PMID: 29631648, PMCID: PMC6075696, DOI: 10.1017/s2040174418000181.Peer-Reviewed Original ResearchConceptsInfant birth weightBirth weightPrenatal cortisolMaternal prenatal cortisolWirral Child HealthFetal growthChild healthAffective disordersDevelopment Study cohortGeneral population estimatesSex-dependent mannerSex-specific mechanismsInverse probability weightsSex-specific effectsCurve cortisolWeeks' gestationGestational ageHospital recordsStudy cohortRisk stratifierFetal programmingGeneral populationGlucocorticoid mechanismsSignificant associationCortisolDNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2017
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression
Silveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development And Psychopathology 2017, 29: 1601-1617. PMID: 29162172, DOI: 10.1017/s0954579417001262.Peer-Reviewed Original ResearchConceptsEarly life adversityNeurodevelopmental outcomesPrenatal adversityChild Behavior ChecklistGenetic scoreAdversity scoreLife adversityCommunity birth cohortYears of agePervasive developmental problemsMaternal smokingGestational ageBirth weightLater riskPrenatal exposureAdverse exposuresBehavioral alterationsBirth cohortSerotonin transporter geneFetal periodPostnatal influencesPrefrontal cortexRelevant single nucleotide polymorphismsSerotonin transporterPrenatal lifeBroader Focus Required to Understand the Effects of the Perinatal Environment on Child Neurodevelopment: Response to Bell and Chimata
O'Donnell KJ, Meaney MJ. Broader Focus Required to Understand the Effects of the Perinatal Environment on Child Neurodevelopment: Response to Bell and Chimata. American Journal Of Psychiatry 2017, 174: 999-1000. PMID: 28965461, DOI: 10.1176/appi.ajp.2017.17040376r.Books