Featured Publications
Full facial retransplantation in a female patient—Technical, immunologic, and clinical considerations
Kauke M, Panayi AC, Safi A, Haug V, Perry B, Kollar B, Nizzi M, Broyles J, Annino DJ, Marty FM, Sinha I, Lian CG, Murphy GF, Chandraker A, Pomahac B. Full facial retransplantation in a female patient—Technical, immunologic, and clinical considerations. American Journal Of Transplantation 2021, 21: 3472-3480. PMID: 34033210, DOI: 10.1111/ajt.16696.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFemaleGraft RejectionHumansReoperationTransplantation, HomologousConceptsChronic antibody-mediated rejectionPatient underwent retransplantationRecurrent cellular rejectionAntibody-mediated rejectionImmediate postoperative phaseInterposition vein graftAllograft lossCellular rejectionFirst allograftOlder allograftsRejection episodesUnderwent retransplantationSecond transplantationFirst transplantPostoperative outcomesAllotransplant recipientsPostoperative phaseVein graftsHyperacute rejectionFacial nerveOutcomes 6Arterial anastomosisRetransplantationSurgical techniquePsychosocial management
2023
Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma
Noel O, Dumbrava M, Daoud D, Kammien A, Kauke-Navarro M, Pomahac B, Colen D. Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma. Annals Of Plastic Surgery 2023, 92: 100-105. PMID: 37962243, DOI: 10.1097/sap.0000000000003731.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFacial InjuriesHumansPlastic Surgery ProceduresUpper ExtremityVascularized Composite AllotransplantationConceptsHand traumaHand/upper extremityLong-term outcomesUpper extremity traumaDifferent reconstructive optionsUse of prosthesesExtremity traumaBenefit profileUpper extremityReconstructive optionsComposite allotransplantationFace traumaHand reconstructionTraumaClinical realityPrimary optionProsthesisPatientsVCAInsights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFacial TransplantationGraft RejectionGraft SurvivalProteomicsVascularized Composite AllotransplantationConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllograftsTolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models
Huelsboemer L, Kauke-Navarro M, Reuter S, Stoegner V, Feldmann J, Hirsch T, Kueckelhaus M, Dermietzel A. Tolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models. Transplant International 2023, 36: 10955. PMID: 36846605, PMCID: PMC9946984, DOI: 10.3389/ti.2023.10955.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsComposite Tissue AllograftsGraft RejectionImmune ToleranceImmunosuppressive AgentsTransplantation, HomologousVascularized Composite AllotransplantationConceptsTolerance inductionLong-term effectsAnimal modelsImmune systemDonor-specific toleranceLong-term outcomesRecipient's immune systemPreclinical animal modelsNovel therapeutic strategiesPre-clinical studiesVascularized Composite AllotransplantationChronic rejectionImmunosuppressive protocolsTransplant recipientsAllograft rejectionOrgan dysfunctionPreclinical modelsComposite allograftsTherapeutic strategiesComposite allotransplantationClinical practiceIS protocolClinical translationInductionReview article
2021
Dynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants.
Kauke M, Safi AF, Palmer WJ, Kollar B, Nelms L, Tchiloemba B, Haug V, Pomahac B. Dynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants. Plastic & Reconstructive Surgery 2021, 147: 722-727. PMID: 33620943, DOI: 10.1097/prs.0000000000007673.Peer-Reviewed Original ResearchConceptsMaxillary sinusFace transplant recipientsTransplant recipientsAllograft rejectionTissue changesBiopsy-proven allograft rejectionDiagnosis of rejectionMedication side effectsMaxillary sinus mucosaIndividualized treatment strategiesTissue allograft rejectionVascularized composite allotransplantsFace transplant patientsDynamic tissue changesRadiologic biomarkersRejection gradeTransplant patientsMucosal swellingSinonasal tractSinus changesSinus mucosaClinical managementTomographic scanPathologic changesTreatment strategies
2020
Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation
Kauke-Navarro M, Tchiloemba B, Haug V, Kollar B, Diehm Y, Safi AF, Treister NS, Annino DJ, Marty FM, Lian CG, Murphy GF, Pomahac B. Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 1562-1571. PMID: 33376080, DOI: 10.1016/j.bjps.2020.11.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedComposite Tissue AllograftsFaceFemaleGraft RejectionHumansMaleMiddle AgedMouth MucosaNasal MucosaRetrospective StudiesVascularized Composite AllotransplantationConceptsNasal mucous membraneMucous membranesMucosal inflammationMucosal lesionsBanff gradeInflammatory mucosal lesionsUlceration/erosionRetrospective cohort studyClinico-pathologic variablesMucosal rejectionCohort studyCutaneous changesIndependent predictorsMucosal assessmentOral lesionsSkin rejectionSinonasal mucosaCommon lesionsMedical recordsUnivariate analysisCutaneous pathologyBuccal mucosaNasal vestibuleOral cavityComposite allotransplantationMucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review.
Kauke M, Safi AF, Zhegibe A, Haug V, Kollar B, Nelms L, Palmer WJ, Tchiloemba B, Lian CG, Murphy GF, Pomahac B. Mucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review. Transplantation 2020, 104: 2616-2624. PMID: 32053572, DOI: 10.1097/tp.0000000000003171.Peer-Reviewed Original ResearchConceptsMucosal rejectionSystematic reviewRejection gradeMucosal biopsiesPatient managementComposite allotransplantationDiagnosis of rejectionFunction of patientsFacial Vascularized Composite AllotransplantationMeta-Analyses (PRISMA) guidelinesMEDLINE/PubMedPreferred Reporting ItemsVascularized Composite AllotransplantationPosttransplant periodBiopsy gradeSkin rejectionMucosa biopsiesAllograft skinAnimal studiesReporting ItemsBiopsyRejection processFacial allotransplantsMucosaTarget tissues