2021
Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis
Shibata M, Pattabiraman K, Muchnik SK, Kaur N, Morozov YM, Cheng X, Waxman SG, Sestan N. Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis. Nature 2021, 598: 489-494. PMID: 34599306, PMCID: PMC9018127, DOI: 10.1038/s41586-021-03952-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcium-Binding ProteinsDendritesEnhancer Elements, GeneticFemaleHumansIntercellular Signaling Peptides and ProteinsMacacaMental DisordersMiceNerve Tissue ProteinsNervous System DiseasesNeural Cell Adhesion MoleculesPhylogenyPrefrontal CortexPromoter Regions, GeneticSOXD Transcription FactorsTranscriptomeUp-RegulationConceptsCerebellin 2Prefrontal cortexCerebral cortex regionsDendritic spine formationInitiation of synaptogenesisLaminar distributionDendritic spinesNervous systemNeuropsychiatric disordersSpine formationLevel of expressionCortex regionsGenetic humanizationCortical gradientsDisproportionate increaseSpecies differencesNeurexinsSpinogenesisDysfunctionMolecular basisPathogenesisExpressionCortexSynaptogenesisSpine
2013
A High-Resolution Enhancer Atlas of the Developing Telencephalon
Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Kaplan T, Kriegstein AR, Rubin EM, Ovcharenko I, Pennacchio LA, Rubenstein JL. A High-Resolution Enhancer Atlas of the Developing Telencephalon. Cell 2013, 152: 895-908. PMID: 23375746, PMCID: PMC3660042, DOI: 10.1016/j.cell.2012.12.041.Peer-Reviewed Original ResearchConceptsForebrain enhancersDistant-acting enhancersGene regulatory mechanismsTransgenic mouse embryosEnhancer architectureVivo enhancerEpigenomic analysisRegulatory sequencesMouse embryosRegulatory mechanismsTelencephalon developmentMammalian telencephalonVivo expressionEnhancerCritical roleDeveloping TelencephalonSequenceNeurodevelopmental disordersTelencephalonCortex tissueVivo activityGenesEmbryosSpeciesAtlas