2023
AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunity
Seth A, Yokokura Y, Choi J, Shyer J, Vidyarthi A, Craft J. AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunity. Journal Of Experimental Medicine 2023, 220: e20211110. PMID: 36820828, PMCID: PMC9998660, DOI: 10.1084/jem.20211110.Peer-Reviewed Original ResearchConceptsTfh cellsT cellsFollicular helper T cellsLupus-prone miceT cell subsetsTfh cell developmentHelper T cellsHumoral immune responseT cell functionGerminal center B cellsT cell statesRenal injuryAutoantibody productionCell subsetsPrimary T cellsImmune responseB cellsPharmacologic inhibitionTherapeutic insightsCell functionGenetic disruptionNFATCell developmentCellsGene expression
2014
Transcription factor Ascl2 limits Tfh cell differentiation and function (IRC8P.493)
Bertino S, Dong X, Laidlaw B, Craft J. Transcription factor Ascl2 limits Tfh cell differentiation and function (IRC8P.493). The Journal Of Immunology 2014, 192: 190.21-190.21. DOI: 10.4049/jimmunol.192.supp.190.21.Peer-Reviewed Original ResearchTfh cellsIL-4T cellsAntibody productionCD4 T cell compartmentFollicular helper T cellsTfh cell subsetsTfh cell differentiationTfh cell developmentIL-4 productionT cell compartmentHelper T cellsLarge germinal centersGerminal center responseSecretion of cytokinesGerminal center formationB cell maturationGC B cellsIL-21Germinal centersB cellsCenter responseCell maturationConditional deletionMiceB Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen
Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, Craft J. B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen. The Journal Of Immunology 2014, 192: 3166-3179. PMID: 24610013, PMCID: PMC3991608, DOI: 10.4049/jimmunol.1302617.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAntigens, CD19B-LymphocytesCell ProliferationDNA-Binding ProteinsFlow CytometryInducible T-Cell Co-Stimulator LigandMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, ConfocalNitrophenolsOvalbuminPhenylacetatesProto-Oncogene Proteins c-bcl-6Reverse Transcriptase Polymerase Chain ReactionT-LymphocytesT-Lymphocytes, Helper-InducerConceptsCognate B cellsTfh cell developmentB cellsICOS ligandFollicular Th cell developmentCell developmentNoncognate B cellsFollicular helper cell developmentTfh cell differentiationAg-specific B cellsICOS-L expressionB cell expressionTh cell developmentGerminal center differentiationICOS blockadeTfh cellsAg deliverySystemic autoimmunityCell expressionCell maturationICOSCellsDeliveryCell differentiationCells display
2012
T cells that promote B‐Cell maturation in systemic autoimmunity
Weinstein JS, Hernandez SG, Craft J. T cells that promote B‐Cell maturation in systemic autoimmunity. Immunological Reviews 2012, 247: 160-171. PMID: 22500839, PMCID: PMC3334351, DOI: 10.1111/j.1600-065x.2012.01122.x.Peer-Reviewed Original ResearchConceptsSystemic autoimmunityT cellsB cell maturationExtrafollicular fociGerminal centersB cellsTfh cellsImmune responseFollicular helper T cellsT cell-dependent immune responsesEnd-organ injuryB cell folliclesSystemic autoimmune diseaseTfh cell developmentHuman Tfh cellsSelf-reactive B cellsT helper cellsHelper T cellsSecondary lymphoid organsNormal immune responseT cell helpPlasma cell formationPathogenic autoantibodiesLymph nodesAutoimmune diseases
2011
Upregulation of Bcl6 expression in Follicular Helper T cells (TFH) requires both dendritic and antigen-specific B cell help. (63.10)
Weinstein J, Poholek A, Hernandez S, Nowyhead H, Bertino S, Craft J. Upregulation of Bcl6 expression in Follicular Helper T cells (TFH) requires both dendritic and antigen-specific B cell help. (63.10). The Journal Of Immunology 2011, 186: 63.10-63.10. DOI: 10.4049/jimmunol.186.supp.63.10.Peer-Reviewed Original ResearchTfh cell developmentCD4 T cellsAg-specific B cellsDendritic cellsT cellsB cellsFollicular entryTfh cellsBCL6 expressionTCR transgenic CD4 T cellsFollicular helper T cellsT cell surface markersTransgenic CD4 T cellsTfh cell markersTfh cell phenotypeDonor T cellsB cell helpHelper T cellsB-cell CLL/lymphoma 6Polyclonal B cellsFunctional B cellsCell developmentCell surface markersNP-OVAWild-type controls
2009
Bcl6 is required for the development of T follicular helper cells marked by downregulation of P-selectin glycoprotein ligand-1 (46.7)
Poholek A, Hernandez S, Chandele A, Dong X, Odegard J, Kaech S, Dent A, Craft J. Bcl6 is required for the development of T follicular helper cells marked by downregulation of P-selectin glycoprotein ligand-1 (46.7). The Journal Of Immunology 2009, 182: 46.7-46.7. DOI: 10.4049/jimmunol.182.supp.46.7.Peer-Reviewed Original ResearchTfh cellsP-selectin glycoprotein ligand-1IL-21PD-1T cellsFollicular helper T cellsAbsence of ICOSExpression of CXCR5Follicular helper cellsTfh cell developmentHelper T cellsLigand 1B cell maturationTranscriptional repressor BCL6ICOS signalingNew surface markersHelper cellsGerminal centersB cellsCell maturationSurface markersExpression of BCL6BCL6CXCR5Downregulation