2024
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-life
2006
Endothelial Cell Dysfunction, Injury and Death
Pober JS, Min W. Endothelial Cell Dysfunction, Injury and Death. Handbook Of Experimental Pharmacology 2006, 176/II: 135-156. PMID: 16999227, DOI: 10.1007/3-540-36028-x_5.Peer-Reviewed Original ResearchConceptsTumor necrosis factorCytolytic T lymphocytesEC injuryEndothelial cellsReactive oxygen speciesEndothelial cell dysfunctionMacrophage-derived cytokinesVascular endothelial cellsEndothelial dysfunctionNecrosis factorCell dysfunctionT lymphocytesInjuryCommon mediatorInflammationDysfunctionDeathOxygen speciesCytokinesLymphocytesNeutrophilsDifferent agentsBiochemical pathways
1998
Allogeneic and xenogeneic vascular injury and protection
Pober JS, Schechner JS, Murray AG, Sultan P, Kirkiles N, Tereb D, Wilson J, McNiff JM, Askenase PW, Tellides G, Lorber MI. Allogeneic and xenogeneic vascular injury and protection. Transplantation Proceedings 1998, 30: 4168-4169. PMID: 9865336, DOI: 10.1016/s0041-1345(98)01381-5.Peer-Reviewed Original Research
1997
Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor.
Mach F, Schönbeck U, Bonnefoy J, Pober J, Libby P. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor. Circulation 1997, 96: 396-9. PMID: 9244201, DOI: 10.1161/01.cir.96.2.396.Peer-Reviewed Original ResearchConceptsLigation of CD40Tissue factorMacrophage functionMonocyte/macrophage functionAcute coronary eventsAcute coronary syndromeAnti-CD40L antibodyHuman monocytes/macrophagesCytokine interleukin-1Mononuclear phagocyte functionMonocytes/macrophagesInduction of collagenaseActivated T cellsCoronary eventsCoronary syndromeMatrix-degrading proteinasesClinical manifestationsPlaque disruptionTumor necrosisT cell membranePlaque ruptureT cellsInterleukin-1Phagocyte functionReceptor CD40Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis
Mach F, Schönbeck U, Sukhova G, Bourcier T, Bonnefoy J, Pober J, Libby P. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 1931-1936. PMID: 9050882, PMCID: PMC20020, DOI: 10.1073/pnas.94.5.1931.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, T-LymphocyteArteriosclerosisB-LymphocytesBlotting, WesternCD40 AntigensCD40 LigandCells, CulturedEndothelium, VascularFlow CytometryGene Expression RegulationHumansImmunohistochemistryInterferon-gammaInterleukin-1MacrophagesMembrane GlycoproteinsMuscle, Smooth, VascularRNA, MessengerSignal TransductionTumor Necrosis Factor-alphaConceptsHuman vascular endothelial cellsSmooth muscle cellsVascular endothelial cellsHuman atherosclerotic lesionsHuman macrophagesCell typesEndothelial cellsMuscle cellsHuman vascular smooth muscle cellsVascular smooth muscle cellsDe novo synthesisCD40 ligandBroad functionsAtherosclerotic lesionsCD40 SignalingTumor necrosis factor alphaFunctional CD40 ligandInvolvement of inflammationCultured human vascular endothelial cellsCD40-CD40 ligandNovo synthesisNecrosis factor alphaParacrine activationNormal arterial tissueNovel source
1992
Expression of vascular cell adhesion molecule-1 in human renal allografts.
Briscoe DM, Pober JS, Harmon WE, Cotran RS. Expression of vascular cell adhesion molecule-1 in human renal allografts. Journal Of The American Society Of Nephrology 1992, 3: 1180-5. PMID: 1282831, DOI: 10.1681/asn.v351180.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntigens, CDAntigens, Differentiation, MyelomonocyticCD3 ComplexCell Adhesion MoleculesE-SelectinEndothelium, VascularGraft RejectionHumansIntercellular Adhesion Molecule-1Kidney TransplantationKidney Tubular Necrosis, AcuteKidney TubulesMacrophagesMonocytesPostoperative ComplicationsT-Lymphocyte SubsetsTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsVascular cell adhesion molecule-1Cell adhesion molecule-1VCAM-1 expressionAdhesion molecule-1Renal allograftsNormal biopsiesMolecule-1Human renal allograft biopsiesMonocyte/macrophage infiltrateEndothelial VCAM-1 expressionAcute tubular necrosisRenal allograft biopsiesT-cell infiltratesT cell infiltrationHuman renal allograftsEndothelial VCAM-1Normal kidney specimensArea of infiltratesMean scoreVascular endothelial cellsAcute rejectionAllograft biopsiesTubular necrosisCell infiltrateClinicopathologic diagnosis