2023
Transendothelial Migration of Human B Cells: Chemokine versus Antigen.
Wang V, Pober J, Manes T. Transendothelial Migration of Human B Cells: Chemokine versus Antigen. The Journal Of Immunology 2023, 211: 923-931. PMID: 37530585, PMCID: PMC10529164, DOI: 10.4049/jimmunol.2200887.Peer-Reviewed Original ResearchConceptsB cellsLeukocyte cell adhesion moleculeTransendothelial migrationEndothelial cellsCell adhesion moleculeAdhesion moleculesPeripheral blood CD19B cell subsetsMemory B cellsInnate immune propertiesSites of inflammationMicrovascular endothelial cellsHuman microvascular endothelial cellsHuman B cellsBlood CD19Peripheral bloodCell subsetsVenular flowT cellsICAM-1VCAM-1Immune propertiesSyk activationChemokinesExpression of genes
2020
Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations
Wang K, Zhang H, He Y, Jiang Q, Tanaka Y, Park IH, Pober JS, Min W, Zhou HJ. Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: 2171-2186. PMID: 32640906, DOI: 10.1161/atvbaha.120.314586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBrainCell CommunicationCell MovementCells, CulturedCoculture TechniquesEndothelial CellsFemaleFocal AdhesionsGene DeletionGenetic Predisposition to DiseaseHemangioma, Cavernous, Central Nervous SystemHumansMaleMembrane ProteinsMice, KnockoutMicrovesselsMyocytes, Smooth MusclePaxillinPericytesPhenotypeProtein StabilityProto-Oncogene ProteinsSignal TransductionConceptsCerebral cavernous malformationsBrain mural cellsCCM lesionsMural cellsCavernous malformationsSevere brain hemorrhageCCM pathogenesisSmooth muscle cellsWeeks of ageCell-specific deletionMural cell coverageBrain pericytesBrain hemorrhageNeonatal stageBrain vasculatureLesionsEntire brainMuscle cellsCerebral cavernous malformation 3Endothelial cellsMicePericytesSpecific deletionAdhesion formationPathogenesis
2013
A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment
Lauridsen HM, Pober JS, Gonzalez AL. A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment. The FASEB Journal 2013, 28: 1166-1180. PMID: 24297702, PMCID: PMC3929680, DOI: 10.1096/fj.13-240986.Peer-Reviewed Original ResearchConceptsAdhesion molecule-1Cell adhesion molecule-1Molecule-1Endothelial cellsPostcapillary venulesBasement membraneVascular cell adhesion molecule-1Intercellular adhesion molecule-1Tumor necrosis factor αMicrovascular leukocyte recruitmentNecrosis factor αLate antigen-4Platelet endothelial cell adhesion molecule-1TNF-α activationInflammatory cascadeAntigen-4Neutrophil extravasationInterleukin-8Leukocyte recruitmentNeutrophil adhesionFactor αTNFPericytesVenular shear stressAnti-CD99
2001
Human Endothelial Cell Presentation of Antigen and the Homing of Memory/Effector T Cells to Skin
POBER J, KLUGER M, SCHECHNER J. Human Endothelial Cell Presentation of Antigen and the Homing of Memory/Effector T Cells to Skin. Annals Of The New York Academy Of Sciences 2001, 941: 12-25. PMID: 11594565, DOI: 10.1111/j.1749-6632.2001.tb03706.x.Peer-Reviewed Original ResearchConceptsDermal endothelial cellsEffector T cell populationsMicrovascular endothelial cellsMemory T cellsT cell populationsT cellsDermal microvascular endothelial cellsEndothelial cellsE-selectinMemory/effector T cellsAntigen-specific inflammatory responsesHuman dermal endothelial cellsAdhesion moleculesEndothelial cell presentationEffector T cellsT cell recruitmentCutaneous immune reactionsClass II MHC moleculesHours of challengeAntigen-independent mannerVCAM-1 expressionCell populationsHuman dermal microvascular endothelial cellsCultured human endothelial cellsLeukocyte adhesion moleculesSuppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting
Mesri M, Morales-Ruiz M, Ackermann E, Bennett C, Pober J, Sessa W, Altieri D. Suppression of Vascular Endothelial Growth Factor-Mediated Endothelial Cell Protection by Survivin Targeting. American Journal Of Pathology 2001, 158: 1757-1765. PMID: 11337373, PMCID: PMC1891951, DOI: 10.1016/s0002-9440(10)64131-4.Peer-Reviewed Original ResearchApoptosisCell MovementCells, CulturedDNADNA, AntisenseDose-Response Relationship, DrugEndothelial Growth FactorsEndothelium, VascularGene Expression RegulationHumansInhibitor of Apoptosis ProteinsLymphokinesMicrotubule-Associated ProteinsNeoplasm ProteinsProteinsRNA, MessengerSurvivinVascular Endothelial Growth Factor AVascular Endothelial Growth Factors
1992
Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration.
Briscoe DM, Cotran RS, Pober JS. Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration. The Journal Of Immunology 1992, 149: 2954-60. PMID: 1383333, DOI: 10.4049/jimmunol.149.9.2954.Peer-Reviewed Original ResearchConceptsT cell infiltrationEndothelial VCAM-1 expressionVCAM-1 expressionIL-4Cell infiltrationEndothelial leukocyte adhesion moleculeVCAM-1T cellsAbility of TNFT-cell-rich infiltrateImmunocytochemical stainingVascular cell adhesion molecule-1Endothelial cell adhesion molecule expressionAdhesion moleculesCell adhesion molecule-1Adhesion molecules ELAM-1Cell adhesion molecule expressionInjection of LPST cell extravasationAdhesion molecule expressionEndothelial VCAM-1Tumor necrosis factorAdhesion molecule-1Endothelial adhesion moleculesLeukocyte adhesion molecules
1991
Immunologic Interactions of T Lymphocytes with Vascular Endothelium
Pober J, Cotran R. Immunologic Interactions of T Lymphocytes with Vascular Endothelium. Advances In Immunology 1991, 50: 261-302. PMID: 1950797, DOI: 10.1016/s0065-2776(08)60827-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntigen-Presenting CellsCell MovementEndothelium, VascularHLA AntigensHumansLymphocyte ActivationT-LymphocytesConceptsMemory T cellsT cellsVascular endotheliumPrimary antigen-presenting cellsAntigen-presenting functionAntigen-presenting cellsNaive T cellsContext of transplantationEffective T cell activationCultured human endothelial cellsT cell activationVivo immune systemLymph nodesHuman endothelial cellsHypersensitivity reactionsImmunologic interactionsIL-8Preferential homingT lymphocytesInflammatory sitesAntigen specificityImmune systemRejection reactionCell activationMemory responses