2024
Multi-center retrospective review of vitiligo-like lesions in breast cancer patients treated with cyclin-dependent kinase 4 and 6 inhibitors
Bang A, Fay C, LeBoeuf N, Etaee F, Leventhal J, Sibaud V, Arbesman J, Wang J, Kwong B. Multi-center retrospective review of vitiligo-like lesions in breast cancer patients treated with cyclin-dependent kinase 4 and 6 inhibitors. Breast Cancer Research And Treatment 2024, 204: 643-647. PMID: 38224427, DOI: 10.1007/s10549-023-07217-2.Peer-Reviewed Original ResearchVitiligo-like lesionsProgression-free survivalSurvival benefitMedian progression-free survivalAssociated with survival benefitSkin-directed therapiesMetastatic breast cancerSun-exposed areasPotential treatment optionCyclin-dependent kinase 4ConclusionClinical characteristicsMild repigmentationRuxolitinib creamTopical ruxolitinibMethodsRetrospective reviewResultsMedian ageClinical characteristicsCase reportTreatment optionsBreast cancerKinase inhibitorsCDK4/6iInternational cohortPatientsQuality of life
2020
Potentially life-threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors
Coleman EL, Olamiju B, Leventhal JS. Potentially life-threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors. Oncology Reports 2020, 45: 891-898. PMID: 33650659, PMCID: PMC7859912, DOI: 10.3892/or.2020.7911.Peer-Reviewed Original ResearchConceptsSevere cutaneous adverse reactionsTyrosine kinase inhibitorsLife-threatening severe cutaneous adverse reactionsAcute generalized exanthematous pustulosisEpidermal growth factor receptorStevens-Johnson syndromeCutaneous adverse reactionsToxic epidermal necrolysisVascular endothelial growth factorGrowth factor receptorAnaplastic lymphoma kinasePlatelet-derived growth factorAdverse reactionsFibroblast growth factor receptorFactor receptorApplication of TKIsGrowth factorHuman epidermal growth factor receptorKinase inhibitorsGeneralized exanthematous pustulosisPotential cutaneous toxicityEndothelial growth factorExanthematous pustulosisEpidermal necrolysisCutaneous toxicity