2024
Comparison of organ involvement clusters in Black and White American sarcoidosis patients from a prospectively collected patient registry
Harper L, Tauquir A, Huang S, Wang X, Schupp J, Baughman R, Culver D. Comparison of organ involvement clusters in Black and White American sarcoidosis patients from a prospectively collected patient registry. Respiratory Medicine 2024, 226: 107605. PMID: 38537782, DOI: 10.1016/j.rmed.2024.107605.Peer-Reviewed Original ResearchTherapie der Sarkoidose. Ein Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP)
Skowasch D, Bonella F, Buschulte K, Kneidinger N, Korsten P, Kreuter M, Müller-Quernheim J, Pfeifer M, Prasse A, Quadder B, Sander O, Schupp J, Sitter H, Stachetzki B, Grohé C. Therapie der Sarkoidose. Ein Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP). Pneumologie 2024, 78: 151-166. PMID: 38408486, DOI: 10.1055/a-2259-1046.Peer-Reviewed Original Research
2023
Genetic and geographic influence on phenotypic variation in European sarcoidosis patients
Freitag-Wolf S, Schupp J, Frye B, Fischer A, Anwar R, Kieszko R, Mihailović-Vučinić V, Milanowski J, Jovanovic D, Zissel G, Bargagli E, Rottoli P, Bumbacea D, Jonkers R, Ho L, Gaede K, Dubaniewicz A, Marshall B, Günther A, Petrek M, Keane M, Haraldsdottir S, Bonella F, Grah C, Peroš-Golubičić T, Kadija Z, Pabst S, Grohé C, Strausz J, Safrankova M, Millar A, Homolka J, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Dempfle A, Müller-Quernheim J. Genetic and geographic influence on phenotypic variation in European sarcoidosis patients. Frontiers In Medicine 2023, 10: 1218106. PMID: 37621457, PMCID: PMC10446882, DOI: 10.3389/fmed.2023.1218106.Peer-Reviewed Original ResearchAcute onsetOrgan involvementSarcoidosis phenotypesSingle nucleotide polymorphismsType of onsetCompetent ethics committeeGenetic variantsSarcoidosis cohortSarcoidosis patientsClinical featuresAcute diseaseVariable diseaseFull cohortClinical phenotypeHLA polymorphismObserved associationsEthics CommitteeOnset phenotypeStrong associationGenetic polymorphismsSignificant genetic associationSarcoidosisPatientsCohortAssociation
2021
Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients
Frye B, Potasso L, Farin E, Fichtner U, Birring S, Müller-Quernheim J, Schupp J. Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients. Respiratory Medicine 2021, 188: 106600. PMID: 34530353, DOI: 10.1016/j.rmed.2021.106600.Peer-Reviewed Original ResearchConceptsLeicester Cough QuestionnaireCough-related qualityQuality of lifeSarcoidosis patientsLCQ scoreBody mass indexAbnormal FEV1Routine followLung functionOrgan impairmentTreatable traitsMass indexDisease burdenGranulomatous diseaseFEV1PatientsSarcoidosisBMIScoresQuestionnaireLungCohortFollowDiseaseLife
2019
Translation and psychometric properties of the King’s Sarcoidosis Questionnaire (KSQ) in German language
Farin E, Heyduck K, Frye BC, Birring SS, Müller-Quernheim J, Schupp JC. Translation and psychometric properties of the King’s Sarcoidosis Questionnaire (KSQ) in German language. Health And Quality Of Life Outcomes 2019, 17: 62. PMID: 30975148, PMCID: PMC6460543, DOI: 10.1186/s12955-019-1131-z.Peer-Reviewed Original ResearchConceptsKing's Sarcoidosis QuestionnaireGood psychometric propertiesGerman Clinical Trials RegisterGerman versionResultsOne hundred ninetyClinical Trials RegisterHealth-related qualityPsychometric propertiesGeneral health statusRasch model fitStructural validityInternal consistencyConstruct validityTrials RegisterConsecutive patientsSarcoidosis patientsOutpatient clinicInterventional studyLife QuestionnaireHealth statusSarcoidosisPatientsMeasurement propertiesCronbach's alphaStructured interviews
2018
Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis
Schupp JC, Fichtner UA, Frye BC, Heyduck-Weides K, Birring SS, Windisch W, Criée CP, Müller-Quernheim J, Farin E. Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis. PLOS ONE 2018, 13: e0205308. PMID: 30286204, PMCID: PMC6171952, DOI: 10.1371/journal.pone.0205308.Peer-Reviewed Original ResearchConceptsLeicester Cough QuestionnaireHRQL questionnairesSarcoidosis patientsHealth-related qualityPsychometric propertiesRasch model fitGerman versionInternal consistencyInterventional trialsCommon symptomsPulmonary medicineClinical settingSarcoidosisPatientsFloor effectsProfound negative impactModerate correlationConcurrent validitySkewed responseStructured interviewsQuestionnaireComparative questionnaireCoughCohortSymptomsPhenotypes of organ involvement in sarcoidosis
Schupp J, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho L, Gaede K, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane M, O'Beirne S, Donnelly S, Haraldsdottir S, Jorundsdottir K, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. European Respiratory Journal 2018, 51: 1700991. PMID: 29371378, DOI: 10.1183/13993003.00991-2017.Peer-Reviewed Original ResearchConceptsOrgan involvementIntrathoracic lymph node involvementAbdominal organ involvementLymph node involvementEuropean multicentre studySystemic granulomatous diseaseNew clinical phenotypeHitherto unknown etiologyAcute onsetExtrapulmonary involvementNode involvementSkin involvementFemale patientsMulticentre studyDisease involvementUnknown etiologyCaucasian patientsGranulomatous diseaseHomogenous cohortSarcoidosisPatientsClinical phenotypeStudy centersStandardised protocolDisease phenotype
2017
Transcriptome profiles in sarcoidosis and their potential role in disease prediction
Schupp JC, Vukmirovic M, Kaminski N, Prasse A. Transcriptome profiles in sarcoidosis and their potential role in disease prediction. Current Opinion In Pulmonary Medicine 2017, 23: 487-492. PMID: 28590292, PMCID: PMC5637542, DOI: 10.1097/mcp.0000000000000403.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGenome-wide expression studiesWide expression studiesTranscriptome profilesTranscriptomic dataRNA sequencingExpression studiesGene expressionMolecular mechanismsLarge prospective followTh1 immune responseTranscriptomeNonnecrotizing granulomasProspective followSystemic diseaseDisease progressionTreatment outcomesImmune responseSarcoidosisPotential roleControl tissuesProgressive sarcoidosisKey roleDiseaseTranscriptomicsGranulomasSarcoidosis: Drugs under Investigation
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Sarcoidosis: Drugs under Investigation. Seminars In Respiratory And Critical Care Medicine 2017, 38: 532-537. PMID: 28750466, DOI: 10.1055/s-0037-1603768.Commentaries, Editorials and Letters
2016
Sarkoidose
Frye B, Schupp J, Köhler T, Voll R, Müller-Quernheim J. Sarkoidose. Zeitschrift Für Rheumatologie 2016, 75: 389-401. PMID: 27146405, DOI: 10.1007/s00393-016-0086-2.ChaptersConceptsTumor necrosis factorLymph nodesEndobronchial ultrasound-guided fine-needle aspirationHigh spontaneous remission rateUltrasound-guided fine-needle aspirationSecond-line medicationsThird-line therapyHilar lymph nodesImportant differential diagnosisSpontaneous remission rateRare granulomatous diseaseFine-needle aspirationRemission rateAcute sarcoidosisOrgan impairmentRheumatic diseasesGranulomatous diseaseNecrosis factorDifferential diagnosisNeedle aspirationTherapeutic goalsDiagnostic clarificationSarcoidosisMedicationsTherapyNeue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose. Pneumologie 2016, 70: 231-240. PMID: 26937647, DOI: 10.1055/s-0041-108311.Commentaries, Editorials and LettersConceptsSarcoid patientsGranuloma formationSarcoidosis-associated fatigueClinical pharmacological studiesEtiology of sarcoidosisGenetics of sarcoidosisPulmonary hypertensionMycobacterial antigensAntigen presentationSarcoidosisPositive studiesClinical researchPatientsSubcohortAutoimmunityPositive outcomesNew studiesWide association studyAssociation studiesHypertensionAutoantigensPathomechanismEtiologyNew findingsStudy
2015
Diagnostik und Therapie der Sarkoidose
Frye B, Schupp J, Köhler T, Müller-Quernheim J. Diagnostik und Therapie der Sarkoidose. Der Internist 2015, 56: 1346-1352. PMID: 26563335, DOI: 10.1007/s00108-015-3757-1.ChaptersConceptsIntrathoracic lymph nodesLymph nodesGranulomatous diseaseSteroid-refractory diseaseFurther therapeutic optionsNon-necrotizing granulomasDiagnostik und TherapieLung transplantationSarcoidosis treatmentSteroid therapyCNS involvementStarting doseSymptomatic therapyOrgan impairmentTherapeutic optionsUnd TherapieEndobronchial ultrasoundSpontaneous resolutionBody weightSarcoidosisOrphan diseaseMonoclonal antibodiesDiseaseSymptomatic patternGranulomasImmune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro
Schupp J, Tchaptchet S, Lützen N, Engelhard P, Müller-Quernheim J, Freudenberg M, Prasse A. Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro. BMC Pulmonary Medicine 2015, 15: 75. PMID: 26204953, PMCID: PMC4513400, DOI: 10.1186/s12890-015-0070-7.Peer-Reviewed Original ResearchConceptsHeat-killed P. acnesSarcoid patientsP. acnesBAL cellsBAL fluidTotal IgGImmune responseHealthy volunteersPathogenesis of sarcoidosisSpecific antibodiesGM-CSF productionIgA titresIgA levelsLymph nodesInflammatory cytokinesGranuloma formationMore TNFSarcoidosisPatientsPropionibacterium acnesAcneGM-CSFElevated levelsAntibodiesIgG