2024
The loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse
Stankewich M, Peters L, Morrow J. The loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse. Frontiers In Neuroscience 2024, 18: 1415115. PMID: 39165342, PMCID: PMC11333264, DOI: 10.3389/fnins.2024.1415115.Peer-Reviewed Original ResearchJa/ja miceGranule layerCerebellar granule layerPostnatal day 8Cortical layers 2Cerebellar granule neuronsPostsynaptic density sizeSpectrin gene familyJaundiced miceMature mouse brainExchange transfusionHemolytic anemiaHemolytic pathologiesHematological consequencesMedial habenulaGranule neuronsFatal hemolytic anemiaDay 8Dentate gyrusNeuropsychiatric disordersSpectrin deficiencyWhite matterJa/jaMiceMouse brain
2000
Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: marker for neuronal apoptosis
Nath R, Huggins M, Glantz S, Morrow J, McGinnis K, Nadimpalli R, Wang K. Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: marker for neuronal apoptosis. Neurochemistry International 2000, 37: 351-361. PMID: 10825575, DOI: 10.1016/s0197-0186(00)00040-1.Peer-Reviewed Original ResearchConceptsWestern blotRat cerebellar granule neuronsHuman neuroblastoma SH-SY5Y cellsNeuroblastoma SH-SY5Y cellsSpectrin breakdown productsCerebellar granule neuronsSH-SY5Y cellsApoptotic neuronsCharacterization of antibodiesNeuronal apoptosisNeurodegenerative conditionsGranule neuronsBreakdown productsImmunocytochemical studySH-SY5YII-spectrinWithdrawal-induced apoptosisAntibodiesNeuronsCaspase-3Apoptotic deathPowerful markerChicken antibodiesApoptosisAlpha-spectrin