2023
“Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute
Zafar M, Ziganshin B, Li Y, Ostberg N, Rizzo J, Tranquilli M, Mukherjee S, Elefteriades J. “Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute. The Yale Journal Of Biology And Medicine 2023, 96: 427-440. PMID: 37780996, PMCID: PMC10524815, DOI: 10.59249/lndz2964.Peer-Reviewed Original ResearchConceptsBig dataArtificial intelligenceThoracic aortic aneurysmArtificial intelligence techniquesData setsAortic aneurysmLarge clinical data setsIntelligence techniquesAdvanced machineYale-New Haven HospitalClinical data setsAortic aneurysm patientsAortic root dilatationBicuspid aortic valveProspective clinical databaseNew Haven HospitalLarge genetic data setsIntelligenceSequencing filesThoracoabdominal aortaAortic dilatationMale patientsRisk prognosticationRoot dilatationSurgical treatment
2018
“Getting beyond diameter”: when to replace the aorta?
Tanweer M, Zafar M, Saeyeldin A, Gryaznov A, Puddifant A, Erben Y, Ziganshin B, Elefteriades J. “Getting beyond diameter”: when to replace the aorta? Journal Of Visualized Surgery 2018, 4: 124-124. DOI: 10.21037/jovs.2018.06.04.Peer-Reviewed Original ResearchAortic sizeThoracic aortic aneurysm patientsProgression of TAAAortic aneurysm patientsTimely surgical interventionBody surface areaProphylactic surgical repairSpecific genetic mutationsUse of biomarkersAdvanced imaging techniquesAortic surgeryAortic dissectionSurgical treatmentCatastrophic complicationSurgical repairPrognostic importancePrognostic significanceSurgical interventionAneurysm patientsTAA patientsPatient heightDisease progressionFamily historyFemale genderAnatomical aberrations
1992
Strategies in the Surgical Treatment of Malignant Ventricular Arrhythmias An 8-year Experience
GEHA A, ELEFTERIADES J, HSU J, BIBLO L, HOCH D, BATSFORD W, ROSENFELD L, CARLSON M, JOHNSON N, WALDO A. Strategies in the Surgical Treatment of Malignant Ventricular Arrhythmias An 8-year Experience. Annals Of Surgery 1992, 216: 309-317. PMID: 1417180, PMCID: PMC1242614, DOI: 10.1097/00000658-199209000-00010.Peer-Reviewed Original ResearchConceptsAutomatic implantable cardioverter defibrillatorSubendocardial resectionVentricular tachycardiaSurgical treatmentLV aneurysmSudden deathThirty-day mortality rateSevere LV dysfunctionCongestive heart failureRecurrent ventricular tachycardiaSignificant myocardial ischemiaLong-term survivorsMalignant ventricular arrhythmiasMalignant ventricular tachyarrhythmiasCent of survivorsImplantable cardioverter defibrillatorLong-term survivalActuarial survivalAntiarrhythmic medicationsLate deathsComparable patientsLV dysfunctionConsecutive patientsHeart failureVentricular arrhythmiasMechanical Circulatory Support Decreases Neurologic Complications in the Treatment of Traumatic Injuries of the Thoracic Aorta
Higgins R, Sanchez J, DeGuidis L, Dewar M, Franco K, Kopf G, Elefteriades J, Hammond G, Baldwin J. Mechanical Circulatory Support Decreases Neurologic Complications in the Treatment of Traumatic Injuries of the Thoracic Aorta. JAMA Surgery 1992, 127: 516-519. PMID: 1575620, DOI: 10.1001/archsurg.1992.01420050036003.Peer-Reviewed Original ResearchConceptsMechanical circulatory supportNeurologic complicationsCirculatory supportThoracic aortaTraumatic injuryUnderwent repairAortic cross-clamp timePreoperative systolic blood pressureCross-clamp timeSpinal cord ischemiaSupport groupsInjury Severity ScoreSystolic blood pressureYale-New Haven Medical CenterAortic injuryCord ischemiaBlood pressureSurgical treatmentSeverity scoreMultiple traumaMedical CenterComplicationsPatientsInjuryAortaRight Ventricular Assist Devices and the Surgical Treatment of Right Ventricular Failure
Higgins R, Elefteriades J. Right Ventricular Assist Devices and the Surgical Treatment of Right Ventricular Failure. Cardiology Clinics 1992, 10: 185-192. PMID: 1739958, DOI: 10.1016/s0733-8651(18)30262-5.Peer-Reviewed Original ResearchConceptsVentricular assist deviceCirculatory supportCardiopulmonary bypassAssist deviceSevere right ventricular dysfunctionRight ventricular assist deviceLong-term circulatory supportRight ventricular dysfunctionRight ventricular failureRight ventricular functionHigh-risk patientsIntraaortic balloon pumpMechanical circulatory supportTreatment of patientsInotropic supportProgressive therapyCardiac transplantationVentricular dysfunctionVentricular failureBiventricular failureBalloon pumpSurgical treatmentVentricular functionVolume statusHigh morbidity
1990
Evolving patterns in the surgical treatment of malignant ventricular tachyarrhythmias
Elefteriades J, Biblo L, Batsford W, Rosenfeld L, Henthorn R, Carlson M, Waldo A, Hsu J, Geha A. Evolving patterns in the surgical treatment of malignant ventricular tachyarrhythmias. The Annals Of Thoracic Surgery 1990, 49: 94-100. PMID: 2297279, DOI: 10.1016/0003-4975(90)90362-a.Peer-Reviewed Original ResearchConceptsAutomatic implantable cardioverter defibrillatorResection groupThirty-day mortalityCoronary artery bypassMalignant ventricular tachyarrhythmiasIntractable ventricular arrhythmiasImplantable cardioverter defibrillatorAICD placementArtery bypassSurgical treatmentEndocardial resectionVentricular arrhythmiasVentricular tachyarrhythmiasAntiarrhythmic agentsSudden deathCardioverter defibrillatorResectionMortality figuresPatientsEffective interventionsGreatest overall benefitSurvivalGroupOverall benefitValuable alternative