2023
“Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute
Zafar M, Ziganshin B, Li Y, Ostberg N, Rizzo J, Tranquilli M, Mukherjee S, Elefteriades J. “Big Data” Analyses Underlie Clinical Discoveries at the Aortic Institute. The Yale Journal Of Biology And Medicine 2023, 96: 427-440. PMID: 37780996, PMCID: PMC10524815, DOI: 10.59249/lndz2964.Peer-Reviewed Original ResearchConceptsBig dataArtificial intelligenceThoracic aortic aneurysmArtificial intelligence techniquesData setsAortic aneurysmLarge clinical data setsIntelligence techniquesAdvanced machineYale-New Haven HospitalClinical data setsAortic aneurysm patientsAortic root dilatationBicuspid aortic valveProspective clinical databaseNew Haven HospitalLarge genetic data setsIntelligenceSequencing filesThoracoabdominal aortaAortic dilatationMale patientsRisk prognosticationRoot dilatationSurgical treatmentBicuspid aortopathy does not require earlier surgical intervention
Zafar M, Wu J, Vinholo T, Li Y, Papanikolaou D, Ellauzi H, Ostberg N, Kalyanasundaram A, Kalogerakos P, Mukherjee S, Ziganshin B, Rizzo J, Elefteriades J. Bicuspid aortopathy does not require earlier surgical intervention. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 760-769.e4. PMID: 37088130, DOI: 10.1016/j.jtcvs.2023.04.017.Peer-Reviewed Original ResearchBicuspid aortic valveAdverse aortic eventsEvent-free survivalAortic eventsAortic sizeAortic diameterAortic growth rateEarly surgical interventionLong-term complicationsRisk of complicationsThoracic aortic aneurysmAortic deathComplication rateSurgical repairOperative repairProphylactic surgerySurgical interventionAortic aneurysmAortic valveSurgical correctionBicuspid aortopathyRelative riskExpert centersTAV-ATAAPatientsAortic Size at the Time of Type A and Type B Dissections
Perez Z, Zafar M, Velasco J, Sonsino A, Ellauzi H, John C, Kalyanasundaram A, Ziganshin B, Elefteriades J. Aortic Size at the Time of Type A and Type B Dissections. The Annals Of Thoracic Surgery 2023, 116: 262-268. PMID: 37062339, DOI: 10.1016/j.athoracsur.2023.03.037.Peer-Reviewed Original ResearchConceptsType B dissectionTime of dissectionB dissectionAortic sizeAortic diameterBicuspid aortic valveThoracic aortic aneurysmAortic interventionAortic dissectionSurgical interventionAortic aneurysmFemale sexAortic valveThoracic aortaProphylactic repairUnadjusted regressionLeft shiftLogistic regressionDissectionNew guidelinesType ASize criteriaOddsInterventionTime of typesNonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta
Elefteriades J, Ziganshin B, Zafar M. Nonsize Criteria for Surgical Intervention on the Ascending Thoracic Aorta. Aorta 2023, 11: 071-086. PMID: 37172942, PMCID: PMC10232037, DOI: 10.1055/s-0043-1766114.Peer-Reviewed Original ResearchThoracic aortic aneurysmSurgical interventionAortic eventsAortic dissectionSubsternal chest painBlood pressure elevationBicuspid aortic valveAfferent neural pathwaysAscending thoracic aortaEmission Tomography ImagingPositron emission tomography (PET) imagingAortic stressAscending aneurysmAortic surgeryChest painEarly surgerySpecific genetic aberrationsHigh rupture riskMural thickeningRoot dilatationBicuspid valvePressure elevationAneurysm patientsAortic aneurysmAortic risk
2022
Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation
Dong H, Liu M, Lou X, Leshnower B, Sun W, Ziganshin B, Zafar M, Elefteriades J. Ultimate tensile strength and biaxial stress–strain responses of aortic tissues—A clinical-engineering correlation. Applications In Engineering Science 2022, 10: 100101. DOI: 10.1016/j.apples.2022.100101.Peer-Reviewed Original ResearchThoracic aortic dissectionAortic dissectionAortic tissueDissection eventsBicuspid aortic valveUnderlying genetic abnormalitiesHuman aortic tissueHypertensive episodesAortic arch morphologyAortic valveAdvanced ageTissue injuryConnective tissue ingrowthAged animalsAortic wallInciting factorsGenetic abnormalitiesClinical contextArch morphologyDissectionDissected tissuesTissueResponseTissue ingrowthInjury
2021
Simple Hepatic Cysts as Markers of Thoracic Aortic Disease
C K, BA Z, MA Z, J B, J E. Simple Hepatic Cysts as Markers of Thoracic Aortic Disease. Journal Of Disease Markers 2021, 6 DOI: 10.26420/jdismarkers.2021.1043.Peer-Reviewed Original ResearchThoracic aortic diseaseSimple hepatic cystsBovine aortic archBicuspid aortic valveSimple renal cystsPositive family historyMost patientsAortic diseaseHepatic cystsRetrospective studyAortic aneurysmAortic archAortic valveClinical markersHospital patientsFamily historyRenal cystsTAD patientsControl groupPatientsAneurysmsPrevalenceCystsDisease
2019
MULTIPLE CEREBROVASCULAR EVENTS DUE TO EMBOLIZATION FROM A SEVERELY CALCIFIED BICUSPID AORTIC VALVE: THE “SMOKING GUN”
Kattan C, Elefteriades J, Lombo B. MULTIPLE CEREBROVASCULAR EVENTS DUE TO EMBOLIZATION FROM A SEVERELY CALCIFIED BICUSPID AORTIC VALVE: THE “SMOKING GUN”. Journal Of The American College Of Cardiology 2019, 73: 2897. DOI: 10.1016/s0735-1097(19)33503-x.Peer-Reviewed Original Research
2018
Chapter 10 Guilt by Association Paradigm for Detection of Silent Aortic Aneurysms
Findlay R, Thompson O, Ziganshin B, Elefteriades J. Chapter 10 Guilt by Association Paradigm for Detection of Silent Aortic Aneurysms. 2018, 107-118. DOI: 10.1016/b978-0-12-809979-7.00010-9.Peer-Reviewed Original ResearchThoracic aortic aneurysmAortic aneurysmAortic diseaseGiant cell arteritisAortic arch abnormalitiesBicuspid aortic valveThoracic aortic diseaseAbdominal aortic aneurysmConnective tissue disordersCell arteritisClinical findingsHigh morbidityAortic valveIncidental findingArch abnormalitiesClinical markersFamily historyTissue disordersRenal cystsTAA developmentAneurysmsIntracranial aneurysmsEarly detectionDiseasePatients