2021
Fibronectin‐Mediated Inflammatory Signaling Through Integrin α5 in Vascular Remodeling
Budatha M, Zhang J, Schwartz MA. Fibronectin‐Mediated Inflammatory Signaling Through Integrin α5 in Vascular Remodeling. Journal Of The American Heart Association 2021, 10: e021160. PMID: 34472370, PMCID: PMC8649308, DOI: 10.1161/jaha.121.021160.Peer-Reviewed Original ResearchConceptsTransverse aortic constrictionPathological vascular remodelingVascular remodelingCarotid ligation modelPartial carotid ligation modelAortic constrictionInflammatory activationEndothelial cellsLigation modelArtery wall hypertrophyTransverse aortic constriction (TAC) modelHigh-fat dietIntegrin α5Aortic constriction modelWild-type miceBasement membranePartial carotid ligationVascular endothelial cellsProvisional matrix proteinsAcute atherosclerosisHyperlipidemic ApoEInflammatory markersLigation surgeryWall hypertrophyAcute model
2014
ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis
Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18309-18314. PMID: 25422430, PMCID: PMC4280608, DOI: 10.1073/pnas.1412172111.Peer-Reviewed Original ResearchConceptsProcessing bodiesAlternative splicingEmbryonic lethal abnormal visionRNA processing bodiesNovel posttranscriptional mechanismRNA regulationMRNA turnoverCellular phenotypesPosttranscriptional mechanismsShort isoformTransporter proteinsCellular behaviorPostnatal angiogenesisAngiogenic mRNAsSplicingSprouting behaviorVascular endothelial cellsPathological angiogenesisFactor 1ELAVL1ProteinReduced revascularizationEndothelial cellsExon 11Tumor angiogenesis