2024
Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
Newman B, Jacokes Z, Venkadesh S, Webb S, Kleinhans N, McPartland J, Druzgal T, Pelphrey K, Van Horn J, Consortium F. Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder. PLOS ONE 2024, 19: e0301964. PMID: 38630783, PMCID: PMC11023574, DOI: 10.1371/journal.pone.0301964.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial Communication QuestionnaireSpectrum disorderCharacteristics of autism spectrum disorderAssociated with higher scoresEtiology of autism spectrum disorderMagnetic resonance imagingNeurotypical participantsWhite matter skeletonCommunication QuestionnaireBehavioral functionsFunctional connectivityT1w/T2w ratioNeuronal differencesStructural connectivityAdolescent participantsHigher scoresConduction velocityCortexExtracellular waterDisordersResonance imagingDiffusion MRI techniques
2020
Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD
Lawrence KE, Hernandez LM, Bowman HC, Padgaonkar NT, Fuster E, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Dapretto M, Consortium G. Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD. Cerebral Cortex 2020, 30: 5107-5120. PMID: 32350530, PMCID: PMC7391269, DOI: 10.1093/cercor/bhaa105.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCentral executive networkDefault mode networkFunctional connectivitySalience networkExecutive networkSymptomatology of ASDGreater functional connectivitySex-related biological factorsSample of girlsSN functional connectivitySex differencesAltered functional connectivityASD exhibitNeurotypical individualsNeurocognitive networksTypical developmentNeural mechanismsSpectrum disorderDefault modeMode networkParticipant sexMale samplesYouthGirlsImaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, Green SA, Geschwind DH, Bookheimer SY, Dapretto M. Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational Psychiatry 2020, 10: 82. PMID: 32127526, PMCID: PMC7054353, DOI: 10.1038/s41398-020-0750-9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeurotypical malesOXTR variantsBrain connectivityNeurobiological mechanismsPrefrontal cortexFunctional connectivityNetwork resting-state functional connectivityManifestation of ASDReward-related brain regionsResting-state functional connectivityBrain areasGreater functional connectivityPrefrontal brain areasFemale protective effectSubcortical brain areasSpectrum disorderMotor learningOXTR geneDiagnosis relateHigh OXTRBrain regionsGenetic riskSubcortical regionsSex differences
2011
Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Kaiser MD, Vander Wyk BC, Wu J, Mayes LC, Pelphrey KA. Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion. Developmental Cognitive Neuroscience 2011, 1: 280-294. PMID: 21743819, PMCID: PMC3129780, DOI: 10.1016/j.dcn.2011.02.002.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFunctional magnetic resonance imagingRight insulaVentral anterior cingulate cortexSocial exclusionAtypical neural networksRule violationsBall-tossing gameDorsal prefrontal cortexRepetitive behavior patternsAnterior cingulate cortexASD groupNeural correlatesBrain responsesSocial impairmentNeural responsesCharacteristic deficitsSpectrum disorderNeurobiological differencesPrefrontal cortexCingulate cortexFunctional connectivityComparable gamesInsulaGroup differences
2010
Dissociable brain mechanisms for processing social exclusion and rule violation
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Mayes LC, Pelphrey KA. Dissociable brain mechanisms for processing social exclusion and rule violation. NeuroImage 2010, 54: 2462-2471. PMID: 20974272, PMCID: PMC3006641, DOI: 10.1016/j.neuroimage.2010.10.049.Peer-Reviewed Original ResearchMeSH KeywordsBrainCerebral CortexComputer GraphicsData Interpretation, StatisticalFemaleGames, ExperimentalHumansImage Processing, Computer-AssistedInterpersonal RelationsMagnetic Resonance ImagingMaleNerve NetNeural PathwaysPsychophysicsRejection, PsychologySocial EnvironmentSocial PerceptionYoung AdultConceptsVentral anterior cingulate cortexBrain regionsMagnetic resonance imaging studyDifferential functional connectivityResonance imaging studyFunctional magnetic resonance imaging studyAnterior cingulate cortexCingulate cortex activityMiddle temporal gyrusLateral parietal cortexVentrolateral prefrontal cortexCingulate cortexParietal cortexImaging studiesCortex activityFunctional connectivityTemporal gyrusPrefrontal cortexPosterior cingulate cortex activityActivation patternsCortexBrain mechanismsFunctional dissociationVirtual ball-tossing gameNeural systems