2023
Clinical presentation of group B Streptococcus-infected diabetic foot ulcers
Waldman O, Dexter B, Sulovari A, Oh I. Clinical presentation of group B Streptococcus-infected diabetic foot ulcers. Journal Of Wound Care 2023, 32: s19-s25. PMID: 37405964, DOI: 10.12968/jowc.2023.32.sup7.s19.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersFoot ulcersBlack patientsRecurrent infectionsElevated hemoglobin A1cIntra-operative culturesHemoglobin A1c levelsInitial laboratory valuesSoft tissue infectionsDFU infectionsDFU patientsInitial surgeryOrthopaedic FootAggressive treatmentClinical characteristicsGBS infectionA1c levelsHemoglobin A1cTissue infectionsClinical outcomesClinical presentationInfected boneAppropriate treatmentGroup BLaboratory valuesTranscriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment response
2022
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis
Kwon H, Yu K, Cahill S, Alder K, Dussik C, Kim S, Sharma L, Back J, Oh I, Lee F. Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis. EMBO Molecular Medicine 2022, 14: emmm202115284. PMID: 36354099, PMCID: PMC9728052, DOI: 10.15252/emmm.202115284.Peer-Reviewed Original ResearchConceptsDrug dimethyl fumarateSeptic arthritisIntracellular MRSABacterial joint infectionSoft tissue infectionsAnti-inflammatory effectsInfection-associated inflammationNovel therapeutic paradigmContext of infectionConventional antibiotic treatmentHost cellsAdjuvant administrationSurgical treatmentTissue infectionsClinical symptomsInflammatory machineryJoint infectionBacterial burdenAntibiotic treatmentCell inflammationHost inflammationArthritisInflammationIntraarticular inflammationTherapeutic paradigm
2021
Physical Function and Pain Interference Levels of Hallux Rigidus Patients Before and After Synthetic Cartilage Implant vs Arthrodesis Surgery
Joo PY, Baumhauer JF, Waldman O, Hoffman S, Houck J, Kohring JM, Flemister AS, Ketz JP, DiGiovanni BF, Oh I. Physical Function and Pain Interference Levels of Hallux Rigidus Patients Before and After Synthetic Cartilage Implant vs Arthrodesis Surgery. Foot & Ankle International 2021, 42: 1277-1286. PMID: 34024138, DOI: 10.1177/10711007211007843.Peer-Reviewed Original ResearchConceptsSynthetic cartilage implant hemiarthroplastyPostoperative physical functionPain Interference LevelsPhysical functionSCI cohortHallux rigidusHallux rigidus patientsPainful degenerative conditionsPatients' physical functionTime pointsOutcomes Measurement Information SystemQuality of lifeMeasurement Information SystemPhone surveyStudy time frameArthrodesis surgeryArthrodesis groupComplication ratePROMIS scoresCase seriesSCI groupMean ageAD groupLevel IVTreatment groupsComparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer
Lipof JS, Jones CMC, Daiss J, Oh I. Comparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer. Journal Of Orthopaedic Research® 2021, 39: 2638-2645. PMID: 33543785, PMCID: PMC8339135, DOI: 10.1002/jor.25001.Peer-Reviewed Original ResearchConceptsDiabetic foot infectionsMusculoskeletal infectionsNext-generation sequencingS. agalactiaeS. aureusCulture-directed antibioticsDeep musculoskeletal infectionNegative initial culturesProspective observational studyTime of diagnosisDiabetic foot ulcersLimb salvage effortsPeripheral blood samplesYears of ageFoot infectionsSurgical debridementFoot ulcersRecurrent infectionsTreatment successFair correlationIntraoperative samplesObservational studyBlood samplesUseful adjunctOrthopaedic surgeons
2020
Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections
Sulovari A, Ninomiya MJ, Beck CA, Ricciardi BF, Ketonis C, Mesfin A, Kaplan NB, Soin SP, McDowell SM, Mahmood B, Daiss JL, Schwarz EM, Oh I. Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections. Journal Of Orthopaedic Research® 2020, 39: 2141-2150. PMID: 33274775, PMCID: PMC8175449, DOI: 10.1002/jor.24935.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsFracture-related infectionMusculoskeletal infectionsOrthopedic infectionsHigh diagnostic potentialCultured peripheral blood mononuclear cellsDiagnostic potentialDeep musculoskeletal infectionSignificant patient morbidityBlood mononuclear cellsDiabetic foot ulcersAntigen-specific IgGPeriprosthetic joint infectionStaphylococcus aureusInfection patientsSeptic arthritisSurgical treatmentCurrent diagnostic methodsFoot ulcersJoint infectionAntibody titersMononuclear cellsPatient morbidityPolymicrobial infectionsAntibiotic useIntraoperative Site Vancomycin Powder Application in Infected Diabetic Heel Ulcers With Calcaneal Osteomyelitis
Brodell JD, Kozakiewicz LN, Hoffman SL, Oh I. Intraoperative Site Vancomycin Powder Application in Infected Diabetic Heel Ulcers With Calcaneal Osteomyelitis. Foot & Ankle International 2020, 42: 356-362. PMID: 33185116, DOI: 10.1177/1071100720962480.Peer-Reviewed Original ResearchConceptsDiabetic heel ulcersVancomycin powder applicationTotal calcanectomyVancomycin powderCalcaneal osteomyelitisHeel ulcersClinical outcomesRetrospective case-control studyLimb salvage rateOverall healing rateImproved clinical outcomesCase-control studyLocal tissue irritationMultidrug-resistant bacteriaVancomycin cohortWound complicationsClinical characteristicsOperative complicationsUlcer surgeryDiabetic patientsRevision amputationSalvage rateKnee amputationClinical benefitUnderwent revisionSpecies-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection
Hao SP, Masters EA, Ninomiya MJ, Beck CA, Schwarz EM, Daiss JL, Oh I. Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection. Foot & Ankle International 2020, 42: 363-372. PMID: 33161780, PMCID: PMC7946706, DOI: 10.1177/1071100720965136.Peer-Reviewed Original ResearchConceptsFoot infectionsHost immune responseWound healing statusImmune responseHealing statusFoot ulcer patientsProspective comparative studyCulture-positive patientsCulture-negative patientsSpecific serum antibodiesDominant pathogenAnalysis of serumConventional bacterial cultureUlcer patientsMusculoskeletal infectionsSurgical interventionAntibody titersSerum antibodiesTherapeutic responseInfection diagnosisSpecies-specific immunoassaySurgeon's decisionCulture resultsInfectionLevel IITalar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases.
Kohring JM, Oh I, Baumhauer JF. Talar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases. JBJS Case Connector 2020, 10: e19.00389. PMID: 32649148, DOI: 10.2106/jbjs.cc.19.00389.Peer-Reviewed Original ResearchConceptsCalcium phosphate injectionBone marrow lesionsAvascular necrosisMarrow lesionsExtensive avascular necrosisBone marrow edemaTalar avascular necrosisPoor patient outcomesPhosphate injectionEquivocal improvementPatient's symptomsMarrow edemaPatient outcomesInjection treatmentAnkle jointPatientsLesionsNecrosisPoor qualityOutcomesTreatmentInjectionAvailable researchSubchondroplastyEdemaPeritalar Kinematics With Combined Deltoid-Spring Ligament Reconstruction in Simulated Advanced Adult Acquired Flatfoot Deformity
MacDonald A, Ciufo D, Vess E, Knapp E, Awad HA, Ketz JP, Flemister AS, Oh I. Peritalar Kinematics With Combined Deltoid-Spring Ligament Reconstruction in Simulated Advanced Adult Acquired Flatfoot Deformity. Foot & Ankle International 2020, 41: 1149-1157. PMID: 32495639, DOI: 10.1177/1071100720929004.Peer-Reviewed Original ResearchConceptsSpring ligament tearsLigament reconstructionDeltoid ligament reconstructionLigament tearsTibiotalar jointFlatfoot deformityPeritalar stabilityFlatfoot modelTibiocalcaneonavicular ligamentAdult Acquired Flatfoot DeformityRecent anatomic studiesAcquired Flatfoot DeformityCadaveric flatfoot modelCadaveric foot specimensPeritalar jointsProgressive deformityValgus deformityMedial ligamentValgus alignmentSubtalar jointValgus angleDeltoid ligamentSevere modelMedial stabilityAnatomic studyPrediction of post-interventional physical function in diabetic foot ulcer patients using patient reported outcome measurement information system (PROMIS)
Hao SP, Houck JR, Waldman OV, Baumhauer JF, Oh I. Prediction of post-interventional physical function in diabetic foot ulcer patients using patient reported outcome measurement information system (PROMIS). Foot And Ankle Surgery 2020, 27: 224-230. PMID: 32439241, PMCID: PMC7655606, DOI: 10.1016/j.fas.2020.04.009.Peer-Reviewed Original ResearchConceptsPostoperative physical functionDiabetic foot ulcer patientsBaseline physical functionPreoperative PROMIS scoresFoot ulcer patientsDFU patientsPhysical functionUlcer patientsClinical factorsPROMIS scoresSurgical interventionAmputation levelHealing statusPostoperative PROMIS physical functionPatients' physical functionPROMIS Physical FunctionOutcomes Measurement Information SystemPreoperative physical functionRelevant clinical factorsSignificant univariate correlationRank correlation coefficientMeasurement Information SystemChi-squared testWound healing statusDFU populationChopart Amputation: Questioning the Clinical Efficacy of a Long-standing Surgical Option for Diabetic Foot Infection.
Brodell JD, Ayers BC, Baumhauer JF, DiGiovanni BF, Flemister AS, Ketz JP, Oh I. Chopart Amputation: Questioning the Clinical Efficacy of a Long-standing Surgical Option for Diabetic Foot Infection. Journal Of The American Academy Of Orthopaedic Surgeons 2020, 28: 684-691. PMID: 32769724, DOI: 10.5435/jaaos-d-19-00757.Peer-Reviewed Original ResearchConceptsBaseline physical functionPROMIS Physical FunctionDiabetic foot infectionsPostoperative wound complicationsChopart amputationRevision amputationFoot infectionsWound complicationsPhysical functionWound healingOutcomes Measurement Information System (PROMIS) instrumentsPROMIS physical function scoresPhysical function scoresPatient-reported outcomesJudicious patient selectionExtent of infectionPostoperative complicationsTotal patientsCase seriesClinical outcomesKnee amputationPain interferencePatient selectionSurgical optionsTendon transferAdjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work
Schwarz EM, McLaren AC, Sculco TP, Brause B, Bostrom M, Kates SL, Parvizi J, Alt V, Arnold WV, Carli A, Chen AF, Choe H, Coraça‐Huber D, Cross M, Ghert M, Hickok N, Jennings JA, Joshi M, Metsemakers W, Ninomiya M, Nishitani K, Oh I, Padgett D, Ricciardi B, Saeed K, Sendi P, Springer B, Stoodley P, Wenke JC, Workgroup H. Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work. Journal Of Orthopaedic Research® 2020, 39: 227-239. PMID: 31997412, PMCID: PMC7390691, DOI: 10.1002/jor.24616.Peer-Reviewed Original ResearchConceptsAntibiotic-loaded bone cementMusculoskeletal infectionsLevel 1 evidenceRoutine laboratory testingMinimum biofilm eradication concentrationBone cementBiofilm eradication concentrationALBC useBiofilm-associated bacteriaOrthopedic infectionsClinical relevanceClinical practiceDrug AdministrationDrug susceptibilityLocal deliveryEradication concentrationInfectionAntibiotic resistanceCurrent useEfficacyVivo biofilmsLaboratory testingMicrobial colonizationPropose areasSubstantial lack
2019
Are Prophylactic Perioperative Antibiotics Required for Isolated Forefoot Procedures, Such as Hammertoes?
Oh I, Englund K. Are Prophylactic Perioperative Antibiotics Required for Isolated Forefoot Procedures, Such as Hammertoes? Foot & Ankle International 2019, 40: 17s-18s. PMID: 31322929, DOI: 10.1177/1071100719859374.Peer-Reviewed Original ResearchWhat Is the Best Method to Differentiate Acute Charcot Foot From Acute Infection?
Heidari N, Oh I, Li Y, Vris A, Kwok I, Charalambous A, Rogero R. What Is the Best Method to Differentiate Acute Charcot Foot From Acute Infection? Foot & Ankle International 2019, 40: 39s-42s. PMID: 31322932, DOI: 10.1177/1071100719859892.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCharcot neuroarthropathyPresence of neuropathyAcute Charcot footAcute Charcot neuroarthropathyMultiple diagnostic criteriaLikelihood of infectionCharcot footAcute infectionPhysical examinationHistologic examinationDiagnostic criteriaUnclear casesResonance imagingSkin woundsInfectionBone specimensLaboratory testingExaminationNeuroarthropathyNeuropathyOsteomyelitisScintigraphyErythemaWhat Is the Diagnostic “Algorithm” for Infected Total Ankle Arthroplasty (TAA)?
Heidari N, Oh I, Malagelada F. What Is the Diagnostic “Algorithm” for Infected Total Ankle Arthroplasty (TAA)? Foot & Ankle International 2019, 40: 21s-22s. PMID: 31322963, DOI: 10.1177/1071100719859536.Peer-Reviewed Original ResearchConceptsTotal ankle arthroplastySinus tractJoint aspirationInfected Total Ankle ArthroplastyElevated inflammatory markersSynovial fluid analysisAnkle infectionInflammatory markersOperative interventionArthroplasty infectionClinical symptomsAnkle arthroplastyHistologic examinationSubtalar jointRepeat aspirationSynovial fluidCell countFluid analysisPatientsInfectionNuclear imagingFurther investigationTractAspirationArthroplastyAlterations in tibiotalar joint reaction force following syndesmotic injury are restored with static syndesmotic fixation
Kelly M, Vasconcellos D, Osman WS, Masqoodi N, Fowler X, Elfar JC, Olles MW, Flemister AS, Ketz JP, Oh I. Alterations in tibiotalar joint reaction force following syndesmotic injury are restored with static syndesmotic fixation. Clinical Biomechanics 2019, 69: 156-163. PMID: 31352256, DOI: 10.1016/j.clinbiomech.2019.07.013.Peer-Reviewed Original ResearchConceptsAnatomic reductionSyndesmotic injuriesJoint reaction forcesSyndesmotic screwInjury statesHuman cadaveric lower extremitiesAnkle joint instabilitySignificant differencesCadaveric lower extremitiesMethod of fixationSignificant dissectionSyndesmotic fixationLower extremitiesTibiotalar jointJoint instabilityIntraarticular placementSteinmann pinsInjuryInvasive methodCadaver studyMalreductionReaction forcesQuadricortical screwsJoint mechanicsSignificant increaseEffects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing
Nichols AEC, Oh I, Loiselle AE. Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing. Journal Of Orthopaedic Research® 2019, 38: 13-22. PMID: 31166037, PMCID: PMC6893090, DOI: 10.1002/jor.24388.Peer-Reviewed Original ResearchConceptsTendon healingTendon functionType II diabetes mellitusPro-inflammatory environmentPre-clinical modelsNovel therapeutic strategiesPotential treatment approachRisk of ruptureHealth care challengesDiabetic tendinopathyDiabetes mellitusDiabetic patientsChronic tendinopathyAcute traumaTendon tearsImpaired restorationPathological progressionTendon repairTherapeutic strategiesTreatment approachesTendon structureUS populationCare challengesNative tendon structureHealingEvidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy
MacDonald A, Brodell JD, Daiss JL, Schwarz EM, Oh I. Evidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy. Journal Of Orthopaedic Research® 2019, 37: 1596-1603. PMID: 30908702, PMCID: PMC6659747, DOI: 10.1002/jor.24279.Peer-Reviewed Original ResearchConceptsSalvage therapyQuantitative polymerase chain reactionClinical outcomesClinical toolErythrocyte sedimentation rateFurther surgical interventionC-reactive proteinLower extremity amputationDiabetic foot ulcersEventual clinical outcomeImportant prognostic informationImportant clinical toolDFU patientsFoot salvageFoot ulcersDiabetic footExtremity amputationSurgical interventionPatient counselingAntibiotic treatmentPolymerase chain reactionPrognostic informationClinical signsMicrobiome analysisClinical significanceDeltoid-Spring Ligament Reconstruction in Adult Acquired Flatfoot Deformity With Medial Peritalar Instability
Brodell JD, MacDonald A, Perkins JA, Deland JT, Oh I. Deltoid-Spring Ligament Reconstruction in Adult Acquired Flatfoot Deformity With Medial Peritalar Instability. Foot & Ankle International 2019, 40: 753-761. PMID: 30902021, DOI: 10.1177/1071100719839176.Peer-Reviewed Original ResearchConceptsPROMIS Pain InterferenceSpring ligament tearsPhysical functionPeritalar instabilityRadiographic outcomesLigament reconstructionLigament tearsOsseous correctionFlatfoot deformityPeritalar stabilitySF-36 physical functionTibiocalcaneonavicular ligamentTalo-first metatarsal angleAdult Acquired Flatfoot DeformityPostoperative weightbearing radiographsPostoperative clinical outcomesPROMIS Physical FunctionAnkle Ability MeasureRetrospective case seriesOutcomes Measurement Information SystemViable surgical optionCalcaneal pitch angleTalonavicular coverage angleAcquired Flatfoot DeformityMeasurement Information System