2023
Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory.
Boyd A, Gonzalez-Guarda R, Lawrence K, Patil C, Ezenwa M, O'Brien E, Paek H, Braciszewski J, Adeyemi O, Cuthel A, Darby J, Zigler C, Ho P, Faurot K, Staman K, Leigh J, Dailey D, Cheville A, Del Fiol G, Knisely M, Grudzen C, Marsolo K, Richesson R, Schlaeger J. Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory. Journal Of The American Medical Informatics Association 2023, 30: 1561-1566. PMID: 37364017, PMCID: PMC10436149, DOI: 10.1093/jamia/ocad115.Peer-Reviewed Original ResearchConceptsElectronic health record dataPragmatic clinical trialsHealth record dataPopulation health problemElectronic health record systemsClinical trialsEHR-derived dataHealth record systemsHealth problemsSocial determinantsHealth equityRecord dataVulnerable populationsEHR dataHealthcare systemNational InstituteRecord systemLack of generalizabilityHealthDifferent subsetsGeneralizable researchEPCTsPopulationPotential biasTrials
2020
Progress Report on EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder †
Melnick ER, Nath B, Ahmed OM, Brandt C, Chartash D, Dziura JD, Hess EP, Holland WC, Hoppe JA, Jeffery MM, Katsovich L, Li F, Lu CC, Maciejewski K, Maleska M, Mao JA, Martel S, Michael S, Paek H, Patel MD, Platts-Mills TF, Rajeevan H, Ray JM, Skains RM, Soares WE, Deutsch A, Solad Y, D’Onofrio G. Progress Report on EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder †. Journal Of Psychiatry And Brain Science 2020, 2: e200003. PMID: 32309637, PMCID: PMC7164817, DOI: 10.20900/jpbs.20200003.Peer-Reviewed Original ResearchBuprenorphine/naloxoneOpioid use disorderClinical decision supportPragmatic trialElectronic health recordsUse disordersEmergency Department-Initiated BuprenorphineMulti-centre pragmatic trialRoutine emergency careHealthcare systemRates of EDNaloxone prescribingPilot testingSingle EDEmergency departmentPhysicians' perceptionsEmergency careMortality rateEarly identificationComputable phenotypeUnique physiciansInformed consentCare paradigmHealth recordsIntervention effectiveness