Featured Publications
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC, Rentsch CT, Davis L, Justice A, Sanchez-Roige S, Kampman K, Gelernter J, Kranzler H. Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. Nature Neuroscience 2022, 25: 1279-1287. PMID: 36171425, PMCID: PMC9682545, DOI: 10.1038/s41593-022-01160-z.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveBrainFurinGenome-Wide Association StudyHumansOpioid-Related DisordersConceptsOpioid use disorderGenome-wide association studiesWide significant lociGene expression enrichmentSignificant genetic correlationsCell type groupSignificant lociAssociation studiesExpression enrichmentMillion Veteran ProgramGenetic correlationsUse disordersLociBrain regionsExonic variantsIntronic variantsSubstance use disordersTraitsBiological basisOpioid epidemicPsychiatric disordersVeteran ProgramBrain diseasesTSNARE1FBXW4Identifying and Reducing Bias in Genome-Wide Association Studies of Alcohol-Related Traits
Kranzler HR, Zhou H, Kember RL. Identifying and Reducing Bias in Genome-Wide Association Studies of Alcohol-Related Traits. American Journal Of Psychiatry 2022, 179: 14-16. PMID: 34974756, DOI: 10.1176/appi.ajp.2021.21111107.Peer-Reviewed Original ResearchThe addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates
Hatoum AS, Johnson EC, Colbert SMC, Polimanti R, Zhou H, Walters RK, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates. Neuropsychopharmacology 2021, 47: 1739-1745. PMID: 34750568, PMCID: PMC9372072, DOI: 10.1038/s41386-021-01209-w.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingBehavior, AddictiveGenome-Wide Association StudyHumansOpioid-Related DisordersRisk FactorsSubstance-Related Disorders
2021
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler H, Gelernter J, Harris K, Tucker-Drob E, Waldman I, Palmer A, Harden K, Koellinger P, Dick D. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience 2021, 24: 1367-1376. PMID: 34446935, PMCID: PMC8484054, DOI: 10.1038/s41593-021-00908-3.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityBehavior, AddictiveBehavioral SymptomsComputational BiologyCrimeGenetic Association StudiesGenome-Wide Association StudyHIV InfectionsHumansMeta-Analysis as TopicMultifactorial InheritanceMultivariate AnalysisOpioid-Related DisordersReproducibility of ResultsSelf-ControlSuicideUnemployment