2024
Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study
Rychagov N, Del Re E, Zeng V, Oykhman E, Lizano P, McDowell J, Yassin W, Clementz B, Gershon E, Pearlson G, Sweeney J, Tamminga C, Keshavan M. Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study. Schizophrenia Research 2024, 271: 169-178. PMID: 39032429, PMCID: PMC11384321, DOI: 10.1016/j.schres.2024.07.009.Peer-Reviewed Original ResearchBipolar-Schizophrenia NetworkPsychotic disordersDSM-IVIntermediate Phenotypes studyGyrification changesSchizophrenia compared to controlsBipolar I disorderRight cingulate cortexSchizoaffective disorder probandsBipolar disorder probandsDisorders compared to controlsAge-related differencesSchizoaffective disorderCingulate cortexVerbal memoryBipolar disorderAge-related changesFalse discovery rate correctionSchizophreniaCortical gyrificationHypogyriaFrontal lobeGyrificationDisordersHealthy controls
2019
Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression
Emam H, Steffens DC, Pearlson G, Wang L. Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression. International Journal Of Geriatric Psychiatry 2019, 34: 730-737. PMID: 30761621, PMCID: PMC6480406, DOI: 10.1002/gps.5079.Peer-Reviewed Original ResearchConceptsLate-life depressionSelective serotonin reuptake inhibitorsNonresponder groupFunctional connectivitySSRI responseMADRS scoresResting-state functional magnetic resonance imaging (fMRI) scansMontgomery-Åsberg Depression Rating ScaleMajor depressive disorder patientsPrefrontal cortexMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansSubgenual cingulate areaSerotonin reuptake inhibitorsDepressive disorder patientsAcute treatment responseResonance imaging scansDepression Rating ScaleLower functional connectivityHigher functional connectivityFalse discovery rate correctionResting-state activityDefault mode networkROI connectivityAntidepressant treatment