2023
Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells
Wang S, Song G, Barkestani M, Tobiasova Z, Wang Q, Jiang Q, Lopez R, Adelekan-Kamara Y, Fan M, Pober J, Tellides G, Jane-wit D. Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells. Frontiers In Immunology 2023, 14: 1248027. PMID: 37915586, PMCID: PMC10616247, DOI: 10.3389/fimmu.2023.1248027.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryHuman skin xenograftsSkin xenograftsT cellsPolyfunctional cytokine responsesSolid organ transplantationT cell subsetsResponse of CD4Expression of ICOST cell populationsHumanized mouse modelPeripheral helper cellsAllograft lossIL-21PD-1Reperfusion injuryCytokine responsesVascular inflammationPolyclonal expansionHelper cellsOrgan transplantationMouse modelClinical problemCostimulatory signalsDistinct subsets
2000
Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension
Elefteriades J, Lovoulos C, Tellides G, Goldstein L, Rocco E, Condos S, Kopf G. Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension. The Annals Of Thoracic Surgery 2000, 69: 1858-1863. PMID: 10892937, DOI: 10.1016/s0003-4975(00)01318-7.Peer-Reviewed Original ResearchConceptsRight heart failurePulmonary hypertensionRight heartHeart transplantationHeart failureLeft ventricleOrthotopic heart transplantationSevere pulmonary hypertensionStable sinus rhythmNative aortic valveUnsolved clinical problemPulmonary arterial connectionCardiac transplantationCardiopulmonary bypassArterial connectionsSinus rhythmAortic valveHypertensionClinical problemHeterotopic transplantationTransplantationVentricleEarly causeHeartRecipients