Featured Publications
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBleomycinFibroblastsFibrosisHumansIdiopathic Pulmonary FibrosisInflammationLungMiceConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic target
2008
What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?
Tuan RS, Lee FY, T Konttinen Y, Wilkinson JM, Smith RL. What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? Journal Of The American Academy Of Orthopaedic Surgeons 2008, 16 Suppl 1: s42-8. PMID: 18612013, PMCID: PMC2714366, DOI: 10.5435/00124635-200800001-00010.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsBiocompatible MaterialsBone ResorptionDinoprostoneEndothelial CellsFibroblastsForeign-Body ReactionHumansInterleukin-1Interleukin-6Interleukin-8Joint ProsthesisMacrophage Colony-Stimulating FactorOsteoclastsOsteogenesisProsthesis FailureRANK LigandStem CellsT-LymphocytesTumor Necrosis Factor-alphaConceptsBone lossTNF-alphaIL-1Inflammatory bone lossPro-osteoclastogenic cytokinesGene functionHost inflammatory responsePeriprosthetic bone lossBone marrow-derived mesenchymal stem cellsMarrow-derived mesenchymal stem cellsGenetic variationBasic science dataMolecular mechanismsMesenchymal stem cellsMechanism of actionPeriprosthetic inflammationIL-6IL-8M-SCFInflammatory responseT cellsStem cellsAltered susceptibilityBiologic effectsOsteoprogenitor cells