FOXP3 deficiency, from the mechanisms of the disease to curative strategies
Borna S, Meffre E, Bacchetta R. FOXP3 deficiency, from the mechanisms of the disease to curative strategies. Immunological Reviews 2023, 322: 244-258. PMID: 37994657, DOI: 10.1111/imr.13289.Peer-Reviewed Original ResearchDefective regulatory T cellsPrimary Immune Regulatory DisordersImmune regulatory disordersRegulatory T cellsIPEX patientsAutoimmune manifestationsOrgan involvementTreg cellsImmune dysregulationPeripheral toleranceImmune landscapeImmune toleranceHuman FOXP3Foxp3 deficiencyFOXP3 geneCurative strategiesT cellsEarly diagnosisCarrier mothersNew treatmentsRecurrent manifestationsRegulatory disordersKey transcription factorDiseaseManifestations