2024
96 Molecular and functional identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutation
Borna S, Lee E, Nideffer J, Ramachandran A, Wang B, Mavers M, Narula M, Garrett A, Schulze J, Marois L, Gernez Y, Bathia M, Chong H, Walter J, Kitcharoensakkul M, Lang A, Cooper M, Bertaina A, Meffre E, Roncarolo M, Bacchetta R. 96 Molecular and functional identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutation. Clinical Immunology 2024, 262: 110038. DOI: 10.1016/j.clim.2024.110038.Peer-Reviewed Original Research
2023
Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations
Borna Š, Lee E, Nideffer J, Ramachandran A, Wang B, Baker J, Mavers M, Lakshmanan U, Narula M, Garrett A, Schulze J, Olek S, Marois L, Gernez Y, Bhatia M, Chong H, Walter J, Kitcharoensakkul M, Lang A, Cooper M, Bertaina A, Roncarolo M, Meffre E, Bacchetta R. Identification of unstable regulatory and autoreactive effector T cells that are expanded in patients with FOXP3 mutations. Science Translational Medicine 2023, 15: eadg6822. PMID: 38117899, PMCID: PMC11070150, DOI: 10.1126/scitranslmed.adg6822.Peer-Reviewed Original ResearchConceptsAutoreactive effector T cellsEffector T cellsAutoreactive T cellsT cellsThymic-derived regulatory T cellsHematopoietic stem cell transplantationT cell receptor repertoireEctodermal dystrophy syndromeT-cell abnormalitiesRegulatory T cellsStem cell transplantationT cell autoreactivityCell receptor repertoireTranscription factor Foxp3FOXP3 mutationsImmunomodulatory treatmentImmune dysregulationPeripheral toleranceCell transplantationFoxp3 deficiencyTCR sequencingFactor Foxp3Patient's TCell abnormalitiesPatients