2024
The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-up
2023
The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain
Spann M, Alleyne K, Holland C, Davids A, Pierre-Louis A, Bang C, Oyeneye V, Kiflom R, Shea E, Cheng B, Peterson B, Monk C, Scheinost D. The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain. Neuropsychopharmacology 2023, 49: 476-485. PMID: 37968451, PMCID: PMC10724278, DOI: 10.1038/s41386-023-01765-3.Peer-Reviewed Original ResearchTest-Retest Reliability of Functional Connectivity in Adolescents With Depression
Camp C, Noble S, Scheinost D, Stringaris A, Nielson D. Test-Retest Reliability of Functional Connectivity in Adolescents With Depression. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 21-29. PMID: 37734478, PMCID: PMC10843837, DOI: 10.1016/j.bpsc.2023.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingDepressionDepressive Disorder, MajorFemaleHumansReproducibility of ResultsConceptsMajor depressive disorderIntraclass correlation coefficientTest-retest reliabilityPsychiatric illnessFunctional connectivityMean intraclass correlation coefficientFunctional magnetic resonance imagingMagnetic resonance imagingAverage intraclass correlation coefficientEffect sizeDepressive disorderLongitudinal cohortHealthy individualsMultivariate analysisResonance imagingSymptom severityReproducible biomarkersBrain-behavior associationsGroup differencesDepressionHealthy samplesCorrelation coefficientIllnessAdolescentsBiomarker identification
2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations