2024
The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-up
2023
21. Associations of Physical Frailty With Health Outcomes and Brain Structure in 483,033 Adults From the UK Biobank
Jiang R, Noble S, Sui J, Calhoun V, Scheinost D. 21. Associations of Physical Frailty With Health Outcomes and Brain Structure in 483,033 Adults From the UK Biobank. Biological Psychiatry 2023, 93: s77-s78. DOI: 10.1016/j.biopsych.2023.02.204.Peer-Reviewed Original Research