2024
Mapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity
Pollatou A, Holland C, Stockton T, Peterson B, Scheinost D, Monk C, Spann M. Mapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity. Journal Of Neuroscience 2024, 44: e2363232024. PMID: 38604780, PMCID: PMC11140686, DOI: 10.1523/jneurosci.2363-23.2024.Peer-Reviewed Original ResearchFetal heart rate indicesDorsal anterior cingulate cortexAutonomic nervous systemDorsal anterior cingulate cortex functional connectivityFetal HRHeart rate variabilityBrain regionsFetal heart rate variationWeeks of postmenstrual ageAutonomic nervous system developmentFetal autonomic nervous systemFetal heart rate variabilityAutonomic regulationHeart rate indicesFetal heart rateNervous systemFunctional connectivityHeart rateAnterior cingulate cortex functional connectivityAnterior cingulate cortexChildren's language abilitiesFetal actocardiographInfant brainstemPostmenstrual ageWeeks gestation
2022
Functional Connectivity of the Chemosenses: A Review
Farruggia MC, Pellegrino R, Scheinost D. Functional Connectivity of the Chemosenses: A Review. Frontiers In Systems Neuroscience 2022, 16: 865929. PMID: 35813269, PMCID: PMC9257046, DOI: 10.3389/fnsys.2022.865929.Peer-Reviewed Original ResearchFunctional connectivityConnectivity approachBrain-behavior relationshipsDynamic causal modelingFunctional connectivity approachSeed-based functional connectivityEffective connectivity approachStructural equation modelingTask-based paradigmsCognitive neuroscienceNeural correlatesPsychophysiological interactionStimulus qualityCausal modelingEquation modelingOlfactory paradigmBrain regionsChemosensory perceptionRelative dearthPathways of communicationArousal impacts distributed hubs modulating the integration of brain functional connectivity
Lee K, Horien C, O’Connor D, Garand-Sheridan B, Tokoglu F, Scheinost D, Lake EMR, Constable RT. Arousal impacts distributed hubs modulating the integration of brain functional connectivity. NeuroImage 2022, 258: 119364. PMID: 35690257, PMCID: PMC9341222, DOI: 10.1016/j.neuroimage.2022.119364.Peer-Reviewed Original ResearchMultimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder
Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder. Alcohol Clinical And Experimental Research 2022, 46: 770-782. PMID: 35342968, PMCID: PMC9117461, DOI: 10.1111/acer.14816.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate 5 receptorsDefault mode networkFunctional magnetic resonance imagingReceptor availabilityPositron emission tomographyAUD groupFunctional connectivityReceptor positron emission tomographyResting-state functional magnetic resonance imagingNetwork-level functional connectivityBrain connectivityWeeks of abstinenceGlobal functional connectivityAlcohol use disorderMagnetic resonance imagingFMRI outcomesHealthy controlsSupervised abstinencePET resultsUse disordersSynaptic plasticityResonance imagingBrain regionsEmission tomographyOrbitofrontal cortex
2021
A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder
Goldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder. Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.Peer-Reviewed Original ResearchConceptsLenticular nucleusFunctional connectivityPrefrontal cortexMood statesYoung adultsLimited brain regionsAcute mood statesRight lenticular nucleusBipolar I disorderDorsal prefrontal cortexPrevious neuroimaging studiesWhole-brain approachTemporal functional connectivityFunctional magnetic resonanceLeft prefrontal cortexBrain dysfunctionContralateral homologuesHealthy controlsI disordersDepression scoresICD increasesRight cerebellumBipolar disorderEarly interventionBrain regions
2020
Connectome-based neurofeedback: A pilot study to improve sustained attention
Scheinost D, Hsu TW, Avery EW, Hampson M, Constable RT, Chun MM, Rosenberg MD. Connectome-based neurofeedback: A pilot study to improve sustained attention. NeuroImage 2020, 212: 116684. PMID: 32114151, PMCID: PMC7165055, DOI: 10.1016/j.neuroimage.2020.116684.Peer-Reviewed Original ResearchConceptsFunctional connectivityRt-fMRIReal-time functional magnetic resonance imaging (rt-fMRI) neurofeedbackWhole-brain functional connectivityClinical trial designFunctional magnetic resonance imaging (fMRI) neurofeedbackDistinct brain areasConnectome-based modelsClinical symptomsTrial designBrain areasBrain regionsSustained attentionTherapeutic toolPilot studyBrain activityFunctional connectionsSymptomsNeurofeedbackFunctional networksTraining durationAttention taskComplex functional networksPilot sample
2019
There is no single functional atlas even for a single individual: Functional parcel definitions change with task
Salehi M, Greene AS, Karbasi A, Shen X, Scheinost D, Constable RT. There is no single functional atlas even for a single individual: Functional parcel definitions change with task. NeuroImage 2019, 208: 116366. PMID: 31740342, DOI: 10.1016/j.neuroimage.2019.116366.Peer-Reviewed Original Research
2018
Dynamic functional connectivity during task performance and rest predicts individual differences in attention across studies
Fong AHC, Yoo K, Rosenberg MD, Zhang S, Li CR, Scheinost D, Constable RT, Chun MM. Dynamic functional connectivity during task performance and rest predicts individual differences in attention across studies. NeuroImage 2018, 188: 14-25. PMID: 30521950, PMCID: PMC6401236, DOI: 10.1016/j.neuroimage.2018.11.057.Peer-Reviewed Original ResearchConceptsAttention task performanceDynamic functional connectivityTask performanceIndividual differencesExecutive control brain networksFunctional connectivityFunctional brain scansAttention performanceTask conditionsAttention scoresBrain networksFMRI dataBrain regionsBetter attentionFC featuresFC matricesDFC matrixPearson's rAttentionIndividualsOne-subjectBrain scansConnectivityConnectomeCross-validation approachCerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence
Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence. Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.Peer-Reviewed Original ResearchPosttraumatic stress disorderIntrinsic connectivity distributionMedial prefrontal cortexTensor-based morphometryPTSD groupFunctional connectivityPrefrontal cortexPathophysiology of PTSDGray matter volumeWhole-brain connectivityKey brain regionsMiddle temporal gyrusDorsolateral prefrontal cortexDefault mode networkCentral executive networkFunctional connectivity analysisPFC alterationsCortical alterationsHealthy comparison participantsAltered volumeFunctional alterationsMatter volumeUnmedicated individualsCerebellar involvementBrain regions
2016
Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers
Garrison KA, Sinha R, Lacadie CM, Scheinost D, Jastreboff AM, Constable RT, Potenza MN. Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers. Nicotine & Tobacco Research 2016, 18: 1820-1829. PMID: 26995796, PMCID: PMC4978981, DOI: 10.1093/ntr/ntw088.Peer-Reviewed Original ResearchConceptsFunctional connectivityBrain regionsSupramarginal gyrusFavorite-food cuesSmoking-related alterationsMagnetic resonance imaging studyBrain functional connectivity patternsPrevious functional magnetic resonance imaging (fMRI) studiesTobacco use disorderBrain networksIntrinsic connectivity distributionResonance imaging studyFunctional magnetic resonance imaging studyFunctional connectivity patternsMultiple brain networksSmoking cessationNonsmokersPosterior insulaRolandic operculumSmokersFunctional brain networksImaging studiesGreater connectivityNeural responsesRecent reports
2015
Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity
Finn ES, Shen X, Scheinost D, Rosenberg MD, Huang J, Chun MM, Papademetris X, Constable RT. Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nature Neuroscience 2015, 18: 1664-1671. PMID: 26457551, PMCID: PMC5008686, DOI: 10.1038/nn.4135.Peer-Reviewed Original Research
2014
Resting state functional connectivity predicts neurofeedback response
Scheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C, Hampson M. Resting state functional connectivity predicts neurofeedback response. Frontiers In Behavioral Neuroscience 2014, 8: 338. PMID: 25309375, PMCID: PMC4173810, DOI: 10.3389/fnbeh.2014.00338.Peer-Reviewed Original ResearchObsessive-compulsive disorderOrbitofrontal cortexFunctional connectivityNeurofeedback trainingState functional connectivityWhole-brain connectivityBrain functional connectivityResting-state fMRITarget brain regionsBrodmann area 10Clinical symptomatologyContamination anxietyProminent symptomAnterior prefrontal cortexBrain regionsNeuropsychiatric disordersRs-fMRIBehavioral improvementPrefrontal cortexSame protocolPilot dataBA 10Neurofeedback protocolReliable predictorCortexCoupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data
Scheinost D, Shen X, Finn E, Sinha R, Constable RT, Papademetris X. Coupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data. PLOS ONE 2014, 9: e93544. PMID: 24676034, PMCID: PMC3968179, DOI: 10.1371/journal.pone.0093544.Peer-Reviewed Original ResearchConceptsHealthy controlsIntrinsic connectivity distributionCocaine-dependent subjectsResting-state scansSeed-based analysisConnectivity analysisSimilar brain regionsBasic neuroscience researchMagnetic resonance imaging dataPsychiatric diseasesVoxel-based resultsConnectivity differencesBrain regionsClinical toolFunctional changesFunctional magnetic resonance imaging (fMRI) dataScansVoxel-based methodConnectivity approachNeuroscience researchConnectivity dataBOLD signal and functional connectivity associated with loving kindness meditation
Garrison KA, Scheinost D, Constable RT, Brewer JA. BOLD signal and functional connectivity associated with loving kindness meditation. Brain And Behavior 2014, 4: 337-347. PMID: 24944863, PMCID: PMC4055184, DOI: 10.1002/brb3.219.Peer-Reviewed Original ResearchConceptsPCC/PCuFunctional connectivityGreater functional connectivityIntrinsic connectivityPosterior cingulate cortex/precuneusParahippocampus/hippocampusSeed-based connectivity analysisBOLD signalBlood oxygen level-dependent (BOLD) signalGroup differencesIntrinsic connectivity distributionLevel-dependent signalKindness meditationCortical midline regionsDefault mode networkFunctional magnetic resonanceInsula lobeInferior frontal gyrusSilent repetitionBrain regionsLeft inferior frontal gyrusFrontal gyrusMidline regionSelf-related processingMode network
2013
A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes
Mitchell MR, Balodis IM, DeVito EE, Lacadie CM, Yeston J, Scheinost D, Constable RT, Carroll KM, Potenza MN. A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes. The American Journal Of Drug And Alcohol Abuse 2013, 39: 392-402. PMID: 24200209, PMCID: PMC3827911, DOI: 10.3109/00952990.2013.841711.Peer-Reviewed Original ResearchConceptsTreatment outcomesComparison subjectsCocaine-dependent patientsIntrinsic connectivityCocaine dependenceSubstantia nigraVentral striatumTreatment-seeking cocaine-dependent patientsHealthy comparison subjectsPotential treatment targetGreater intrinsic connectivityRegional brain activationCocaine-dependent groupIntrinsic connectivity analysesNon-addicted individualsBasal gangliaInferior frontal gyrusCocaine-dependent individualsTreatment targetsFMRI Stroop taskSubcortical regionsCocaine abstinenceBrain regionsAnterior insulaFrontal gyrusOrbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks
2012
Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety.
Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T. Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. Journal Of Visualized Experiments 2012 PMID: 22297729, PMCID: PMC3462579, DOI: 10.3791/3535.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOrbitofrontal cortexBrain areasContamination anxietySymptom severityQuarter of patientsSpecific brain areasClinical improvementControl subjectsClinical changesMagnetic resonance imaging dataHealthy subjectsPsychiatric disordersTherapeutic interventionsFunctional magnetic resonance imaging (fMRI) dataBrain regionsObsessive-compulsive symptomsBrain functionTraining subjectsOCD symptom severityBiofeedback interventionConsistent findingCortexBiofeedback trainingBiofeedback