Featured Publications
Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner
Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S. Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Developmental Biology 2015, 407: 195-210. PMID: 26434918, PMCID: PMC5312697, DOI: 10.1016/j.ydbio.2015.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBranchial RegionCardiovascular SystemCell LineageEmbryo, MammalianFemaleFibronectinsIntegrin alpha5beta1LIM-Homeodomain ProteinsMice, KnockoutModels, BiologicalMorphogenesisMutationNeural CrestOrgan SpecificityPharynxPhenotypePregnancySignal TransductionStem CellsT-Box Domain ProteinsThymus GlandTranscription FactorsConceptsPharyngeal arch arteriesCardiovascular developmentIntegrin α5Pharyngeal arch mesodermCell type-specific mannerCell typesMid-gestation lethalityType-specific mannerDistinct cell typesCardiac outflow tractMorphogenetic defectsPharyngeal regionMouse embryogenesisConditional mutantsExtracellular matrix glycoproteinEmbryonic developmentMutagenesis studiesCardiovascular morphogenesisNeural crestPAA formationSurface ectodermDefective formationArch arteriesFN1Matrix glycoprotein
2019
FRS2α-dependent cell fate transition during endocardial cushion morphogenesis
Chen D, Zhu X, Kofler N, Wang Y, Zhou B, Simons M. FRS2α-dependent cell fate transition during endocardial cushion morphogenesis. Developmental Biology 2019, 458: 88-97. PMID: 31669335, DOI: 10.1016/j.ydbio.2019.10.022.Peer-Reviewed Original ResearchConceptsCell fate transitionsFate transitionsAtrioventricular valve developmentInducible endothelial-specific deletionPivotal controllerEmbryonic developmentEndothelial-specific deletionFRS2αValve developmentEndocardial cushionsEndocardial cellsMesenchymal transitionMesenchymal cellsAV cushionsDefective maturationDevelopmental abnormalitiesDeletionAdult endothelium