2022
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science 2022, 378: eabm3233. PMID: 36302024, PMCID: PMC9993714, DOI: 10.1126/science.abm3233.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinogenesisColorectal NeoplasmsDNA DamageGastrointestinal MicrobiomeHeLa CellsHumansIndolesInflammatory Bowel DiseasesMiceMorganella morganiiMutagensConceptsColorectal cancerInflammatory bowel disease patientsBowel disease patientsInflammatory bowel diseaseIndigenous gut microbesBowel diseaseDisease patientsCommensal microbiotaDNA damageColon tumorigenesisElicit DNA damageGut microbesGenotoxic metabolitesGut commensalsMorganella morganiiPatientsGenotoxic chemicalsDiseaseMicrobiotaMetabolitesGenotoxicityCancerMiceFull spectrumDamage
2021
Adaptive immunity induces mutualism between commensal eukaryotes
Ost KS, O’Meara T, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O’Connell R, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Adaptive immunity induces mutualism between commensal eukaryotes. Nature 2021, 596: 114-118. PMID: 34262174, PMCID: PMC8904204, DOI: 10.1038/s41586-021-03722-w.Peer-Reviewed Original ResearchConceptsAdaptive immunityIntestinal immunoglobulin A (IgA) responseIntestinal IgA responsesImmunoglobulin A ResponsesIgA responsesIntestinal damageImmune responseIntestinal microbiotaRelevant vaccinesImmune systemA responsesCommensal fungiImmune selectionCandida speciesImmunityHyphal morphotypesIgAPathogenesisMiceC. albicansPathogenic Candida speciesCandida albicansAlbicansColitisResponse