2024
Presynaptic Proteins and Their Roles in Visual Processing by the Retina
Thoreson W, Zenisek D. Presynaptic Proteins and Their Roles in Visual Processing by the Retina. Annual Review Of Vision Science 2024, 10: 347-375. PMID: 38621251, DOI: 10.1146/annurev-vision-101322-111204.Peer-Reviewed Original ResearchExtract critical featuresGanglion cellsHorizontal cellsRetinal ganglion cellsDendritic synapsesSynaptic feedbackSpatial frequencySynaptic connectionsRetinaBipolar cellsSynapse typesVisual worldSense of visionRibbon synapsesPresynaptic moleculesMotion directionTemporal frequencyCritical featuresPhotoreceptorsPresynaptic proteinsCellsRapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals
Perez C, Dudzinski N, Rouches M, Landajuela A, Machta B, Zenisek D, Karatekin E. Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals. Biophysical Journal 2024, 123: 380a. DOI: 10.1016/j.bpj.2023.11.2322.Peer-Reviewed Original Research
2023
The Effects of Aging on Rod Bipolar Cell Ribbon Synapses
Shrestha A, Rameshkumar N, Boff J, Rajmanna R, Chandrasegaran T, Frederick C, Zenisek D, Vaithianathan T. The Effects of Aging on Rod Bipolar Cell Ribbon Synapses. Cells 2023, 12: 2385. PMID: 37830599, PMCID: PMC10572008, DOI: 10.3390/cells12192385.Peer-Reviewed Original ResearchConceptsRod bipolar cellsRibbon synapsesSynaptic ribbonsCalcium currentBipolar cellsRetinal ganglion cellsAge-related morphological changesBipolar cell ribbon synapsesBipolar cell terminalsGlobal health concernAge-related visual impairmentAge-related changesPlexiform layerGanglion cellsInner nuclearCochlear cellsSensory alterationsCell terminalsVisual impairmentFunctional changesHealth concernCalcium signalsSynapsesCalcium dynamicsRetinaAuthor Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Author Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2023, 14: 3264. PMID: 37277326, PMCID: PMC10241910, DOI: 10.1038/s41467-023-39025-z.Peer-Reviewed Original ResearchRibbon Synapses and Retinal Disease: Review
Frederick C, Zenisek D. Ribbon Synapses and Retinal Disease: Review. International Journal Of Molecular Sciences 2023, 24: 5090. PMID: 36982165, PMCID: PMC10049380, DOI: 10.3390/ijms24065090.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPresynaptic protein complexesRibbon synapsesDefective synaptic transmissionMolecular machineryProtein complexesRetinal malfunctionSynaptic transmissionRetinal diseasesSynaptic ribbonsNeurotransmitter releaseMuscular dystrophyVisual diseaseSynapsesDiseaseSensory informationMutagenesisMachineryPresent understandingSynaptopathyVisual systemReviewPathogenesisRetinaPathologyCorrection: Mesnard et al. Eliminating Synaptic Ribbons from Rods and Cones Halves the Releasable Vesicle Pool and Slows Down Replenishment. Int. J. Mol. Sci. 2022, 23, 6429
Mesnard C, Barta C, Sladek A, Zenisek D, Thoreson W. Correction: Mesnard et al. Eliminating Synaptic Ribbons from Rods and Cones Halves the Releasable Vesicle Pool and Slows Down Replenishment. Int. J. Mol. Sci. 2022, 23, 6429. International Journal Of Molecular Sciences 2023, 24: 1561. PMID: 36675323, PMCID: PMC9863641, DOI: 10.3390/ijms24021561.Peer-Reviewed Original Research
2022
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2022, 13: 6681. PMID: 36335122, PMCID: PMC9637099, DOI: 10.1038/s41467-022-34363-w.Peer-Reviewed Original ResearchConceptsPluripotent cellsAdult tissue homeostasisCell fate commitmentDifferentiated cell fatesLeft-right patterningPluripotent embryonic cellsHuman embryonic stem cellsTemporal transcriptome analysisGene regulatory networksExpense of differentiationEmbryonic stem cellsGerm layer differentiationMembrane depolarizationFate commitmentPluripotent stateCell fateTranscriptome analysisRegulatory networksMyogenic lineageEmbryonic developmentTissue homeostasisDifferentiated fateEmbryonic cellsCandidate genesPluripotencyRapid membrane flow at a presynaptic terminal
Perez C, Dudzinski N, Rouches M, Machta B, Zenisek D, Karatekin E. Rapid membrane flow at a presynaptic terminal. Biophysical Journal 2022, 121: 230a. DOI: 10.1016/j.bpj.2021.11.1599.Peer-Reviewed Original Research
2021
Dynamics of Membrane Tension and Synaptic Vesicle Recycling
Perez C, Dudzinski N, Rouches M, Machta B, Zenisek D, Karatekin E. Dynamics of Membrane Tension and Synaptic Vesicle Recycling. Biophysical Journal 2021, 120: 323a. DOI: 10.1016/j.bpj.2020.11.2037.Peer-Reviewed Original Research
2020
Facile Membrane Flow and Tension Equilibration at a Presynaptic Nerve Terminal
Perez C, Dudzinski N, Rouches M, Matcha B, Zenisek D, Karatekin E. Facile Membrane Flow and Tension Equilibration at a Presynaptic Nerve Terminal. Biophysical Journal 2020, 118: 232a. DOI: 10.1016/j.bpj.2019.11.1372.Peer-Reviewed Original Research
2019
3571 Expression profile of the ribbon synapse protein Ribeye in the zebrafish
Frederick C, Zenisek D. 3571 Expression profile of the ribbon synapse protein Ribeye in the zebrafish. Journal Of Clinical And Translational Science 2019, 3: 11-11. PMCID: PMC6799612, DOI: 10.1017/cts.2019.29.Peer-Reviewed Original ResearchAdult zebrafish retinaZebrafish retinaRibeye proteinsZebrafish tissuesWestern blotProtein isoformsLarval zebrafishZebrafish larvaeSynapse-associated proteinsExpression profilesZebrafishSplice variantsSynapse functionProteinDistinct mechanismsIsoformsLarvalOutstanding questionsHair cellsSynaptic disorderNovel therapeutic interventionsExpressionNeuromastsSynaptic dysregulationPronounced expressionInvestigating Membrane Tension Dynamics in the Neuronal Presynaptic Terminal
Dudzinski N, Zenisek D, Karatekin E. Investigating Membrane Tension Dynamics in the Neuronal Presynaptic Terminal. Biophysical Journal 2019, 116: 313a-314a. DOI: 10.1016/j.bpj.2018.11.1699.Peer-Reviewed Original Research
2017
A Gain-of-Function TRPP2 Ion Channel Created by Mutating Single Amino Acid in the S5 Transmembrane Domain
Pavel M, Lv C, Ng C, Kashyap P, Lam C, Valentino V, Fung H, Campbell T, Zenisek D, Holtzman N, Yu Y. A Gain-of-Function TRPP2 Ion Channel Created by Mutating Single Amino Acid in the S5 Transmembrane Domain. Biophysical Journal 2017, 112: 249a-250a. DOI: 10.1016/j.bpj.2016.11.1364.Peer-Reviewed Original Research
2015
A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals
Graffe M, Zenisek D, Taraska J. A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals. Journal Of Cell Biology 2015, 210: 2102oia145. DOI: 10.1083/jcb.2102oia145.Peer-Reviewed Original Research
2014
Charaterization of Calcium Current and Exocytosis in Zebrafish Lateral Line Hair Cells During Development
Lv C, Santos-Sacchi J, Zenisek D. Charaterization of Calcium Current and Exocytosis in Zebrafish Lateral Line Hair Cells During Development. Biophysical Journal 2014, 106: 597a. DOI: 10.1016/j.bpj.2013.11.3305.Peer-Reviewed Original Research
2013
Synaptic Ribbons Influence the Size and Frequency of Miniature-like Evoked Postsynaptic Currents
Mehta B, Snellman J, Chen S, Li W, Zenisek D. Synaptic Ribbons Influence the Size and Frequency of Miniature-like Evoked Postsynaptic Currents. Neuron 2013, 77: 516-527. PMID: 23395377, PMCID: PMC3569740, DOI: 10.1016/j.neuron.2012.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAminobutyratesAnimalsBiophysicsCo-Repressor ProteinsDNA-Binding ProteinsDose-Response Relationship, DrugElectric StimulationExcitatory Amino Acid AgonistsExcitatory Postsynaptic PotentialsGABA AntagonistsGlycine AgentsHibernationIn Vitro TechniquesMiceMice, Inbred C57BLPatch-Clamp TechniquesPhosphinic AcidsPhosphoproteinsPicrotoxinPyridinesReceptors, AMPARetinaSciuridaeStrychnineSynapsesVisual PathwaysWakefulnessConceptsSynaptic ribbons
2012
Acute Damage to Synaptic Ribbons Differentially Affects Evoked and Spontaneous Neurotransmitter Release from Rod Bipolar Cells
Mehta B, Snellman J, Zenisek D. Acute Damage to Synaptic Ribbons Differentially Affects Evoked and Spontaneous Neurotransmitter Release from Rod Bipolar Cells. Biophysical Journal 2012, 102: 670a. DOI: 10.1016/j.bpj.2011.11.3647.Peer-Reviewed Original ResearchCalcium-Induced Calcium Release (CICR) Triggers Fusion of Individual Synaptic Vesicles in Rod Terminals
Chen M, Zenisek D, Thoreson W. Calcium-Induced Calcium Release (CICR) Triggers Fusion of Individual Synaptic Vesicles in Rod Terminals. Biophysical Journal 2012, 102: 319a. DOI: 10.1016/j.bpj.2011.11.1751.Peer-Reviewed Original Research
2011
Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming
Snellman J, Mehta B, Babai N, Bartoletti TM, Akmentin W, Francis A, Matthews G, Thoreson W, Zenisek D. Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming. Nature Neuroscience 2011, 14: 1135-1141. PMID: 21785435, PMCID: PMC3171202, DOI: 10.1038/nn.2870.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAnimalsBiophysicsCo-Repressor ProteinsDNA-Binding ProteinsElectric StimulationExcitatory Postsynaptic PotentialsExocytosisIn Vitro TechniquesLightMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionPatch-Clamp TechniquesPeptidesPhosphoproteinsProtein BindingRetinaRetinal Bipolar CellsSynapsesSynaptic VesiclesTime FactorsUrodelaDevelopment of new peptide-based tools for studying synaptic ribbon function
Francis AA, Mehta B, Zenisek D. Development of new peptide-based tools for studying synaptic ribbon function. Journal Of Neurophysiology 2011, 106: 1028-1037. PMID: 21653726, PMCID: PMC3154815, DOI: 10.1152/jn.00255.2011.Peer-Reviewed Original Research