Featured Publications
Declines in Pneumonia Mortality Following the Introduction of Pneumococcal Conjugate Vaccines in Latin American and Caribbean Countries
de Oliveira LH, Shioda K, Valenzuela M, Janusz CB, Rearte A, Sbarra AN, Warren JL, Toscano CM, Weinberger DM, Team M. Declines in Pneumonia Mortality Following the Introduction of Pneumococcal Conjugate Vaccines in Latin American and Caribbean Countries. Clinical Infectious Diseases 2020, 73: 306-313. PMID: 32448889, PMCID: PMC8516507, DOI: 10.1093/cid/ciaa614.Peer-Reviewed Original ResearchConceptsPneumonia mortalityPneumonia deathsAge groupsIntroduction of PCVPneumococcal conjugate vaccinePediatric immunization programsYears of ageCause pneumoniaMulticountry evaluationPCV introductionConjugate vaccinePostvaccination periodImmunization programsChildren 2Age strataPopulation-level impactMortalityPneumoniaMortality dataStandardized protocolModerate incidenceDeathNational-level mortality dataVaccinePCV
2021
Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study
Danino D, Ben-Shimol S, Van Der Beek BA, Givon-Lavi N, Avni YS, Greenberg D, Weinberger DM, Dagan R. Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study. Clinical Infectious Diseases 2021, 75: e1154-e1164. PMID: 34904635, PMCID: PMC8754767, DOI: 10.1093/cid/ciab1014.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaInvasive pneumococcal diseasePneumococcal carriagePneumococcal diseaseRespiratory virusesSurveillance projectCOVID-19 pandemicBacteremic pneumococcal pneumoniaNasopharyngeal pneumococcal carriageSpecific respiratory virusesSARS-CoV-2 casesFirst SARS-CoV-2 caseLower respiratory infectionsProspective cohort studyPneumococcal carriage prevalencePneumococcal serotype distributionRespiratory syncytial virusSeasonal respiratory virusesRespiratory virus detectionChest X-rayDensity of colonizationAlveolar pneumoniaPneumococcal pneumoniaCohort studyRespiratory infections
2015
Vaccine against Pneumococcal Pneumonia in Adults.
Weinberger DM, Bruhn CA, Shapiro ED. Vaccine against Pneumococcal Pneumonia in Adults. New England Journal Of Medicine 2015, 373: 92. PMID: 26132955, DOI: 10.1056/nejmc1505366.Peer-Reviewed Original Research
2013
Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive Disease
Weinberger DM, Bruden DT, Grant LR, Lipsitch M, O'Brien KL, Pelton SI, Sanders EA, Feikin DR. Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive Disease. American Journal Of Epidemiology 2013, 178: 1488-1495. PMID: 24013204, PMCID: PMC3813314, DOI: 10.1093/aje/kwt156.Peer-Reviewed Original ResearchMeSH KeywordsCarrier StateHumansIncidenceModels, StatisticalNasopharynxPneumococcal InfectionsPneumococcal VaccinesSentinel SurveillanceConceptsInvasive pneumococcal diseaseIPD incidenceCarriage dataProportion of IPDPCV changesNasopharyngeal carriage studyNasopharyngeal pneumococcal carriagePre-PCV7 periodYears of agePCV7 introductionPneumococcal diseaseCarriage prevalenceNonvaccine serotypesPneumococcal carriageVaccine impactInvasive diseaseCarriage studiesHigh-quality surveillance systemsAmerican Indian populationsSerotype dataIncidenceIndian populationMixed effects modelsSerotypesVaccine
2011
Serotype replacement in disease after pneumococcal vaccination
Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease after pneumococcal vaccination. The Lancet 2011, 378: 1962-1973. PMID: 21492929, PMCID: PMC3256741, DOI: 10.1016/s0140-6736(10)62225-8.Peer-Reviewed Original ResearchMeSH KeywordsCarrier StateHeptavalent Pneumococcal Conjugate VaccineHumansPneumococcal InfectionsPneumococcal VaccinesSerotypingStreptococcus pneumoniaeConceptsNon-vaccine serotypesSerotype replacementPneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineImportant public health benefitsBenefits of vaccinationPublic health benefitsDisease surveillance systemsNVT carriagePneumococcal vaccinationSurveillance biasesConjugate vaccineVaccine serotypesCarriage prevalencePneumococcal serotypesAsymptomatic carriersCarriage dataDiseaseVaccinationHealth benefitsLow invasivenessPrevalenceSerotypesCarriage
2009
Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence
Weinberger DM, Trzciński K, Lu YJ, Bogaert D, Brandes A, Galagan J, Anderson PW, Malley R, Lipsitch M. Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence. PLOS Pathogens 2009, 5: e1000476. PMID: 19521509, PMCID: PMC2689349, DOI: 10.1371/journal.ppat.1000476.Peer-Reviewed Original ResearchConceptsSerotype replacementCarriage prevalenceNasopharyngeal carriageCapsular serotypesNon-vaccine serotypesNeutrophil-mediated killingNasopharyngeal carriage prevalenceCapsular polysaccharideVaccinated populationSerotype prevalenceEpidemiological patternsPrevalent serotypesStreptococcus pneumoniaeBacterial factorsParticular serotypePrevalenceImportant serotypesNovel biological principleSerotypesDifferent serotypesCarriageNeutrophilsBiological differencesKillingVaccination