2012
Effects of Leptin and Melanocortin Signaling Interactions on Pubertal Development and Reproduction
Israel DD, Sheffer-Babila S, de Luca C, Jo YH, Liu SM, Xia Q, Spergel DJ, Dun SL, Dun NJ, Chua SC. Effects of Leptin and Melanocortin Signaling Interactions on Pubertal Development and Reproduction. Endocrinology 2012, 153: 2408-2419. PMID: 22408174, PMCID: PMC3381095, DOI: 10.1210/en.2011-1822.Peer-Reviewed Original ResearchConceptsGnRH neuron activityNeuron activityGnRH neuronsFemale db/db miceDb/db miceMelanocortin 4 receptor activationNeuropeptides neuropeptide YAgouti-related peptideAction potential firingEffects of leptinC-fos expressionMelanocortin-4 receptorInitiation of pubertyHypothalamic hypogonadismDb miceNeuropeptide YMelanocortin agonistsLeptin receptorReceptor activationPubertal developmentΑ-MSHPubertal onsetMelanocortinLeptinDownstream mediator
2005
Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons.
Shimshek DR, Bus T, Grinevich V, Single FN, Mack V, Sprengel R, Spergel DJ, Seeburg PH. Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Endocrinology 2005, 20: 219-31. PMID: 16099814, DOI: 10.1210/me.2005-0262.Peer-Reviewed Original ResearchConceptsAMPA receptorsNMDA receptorsGnRH secretionMale miceN-methyl-D-aspartate receptorsLimbic system neuronsSerum testosterone levelsIsoxazolepropionic acid (AMPA) receptorsIonotropic glutamate receptorsNormal litter sizeMale sexual behaviorGnRH neuronsSeptal neuronsSystem neuronsOvarian morphologyGlutamate receptorsSeptal areaTestosterone levelsControl littermatesMale littermatesPup retrievalMajor subtypesTestis weightMaternal aggressionAcid receptors