Featured Publications
Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL
Lai AC, Toure M, Hellerschmied D, Salami J, Jaime‐Figueroa S, Ko E, Hines J, Crews CM. Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL. Angewandte Chemie International Edition 2015, 55: 807-810. PMID: 26593377, PMCID: PMC4733637, DOI: 10.1002/anie.201507634.Peer-Reviewed Original Research
2015
HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins
Buckley DL, Raina K, Darricarrere N, Hines J, Gustafson JL, Smith IE, Miah AH, Harling JD, Crews CM. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chemical Biology 2015, 10: 1831-1837. PMID: 26070106, PMCID: PMC4629848, DOI: 10.1021/acschembio.5b00442.Peer-Reviewed Original ResearchConceptsChemical probesMore drug-like propertiesFusion proteinSmall-molecule PROTACsProtein degradationDrug-like propertiesE3 ligase ligandChemical genetic toolsSpecific E3 ligasesProtein of interestVHL ligandsHaloTag fusion proteinsE3 ligasesGenetic toolsHeterobifunctional moleculesNumerous proteinsHaloPROTACLigandsPROTACsProteinNovel classAttractive strategyDegradationProbeLigases
2006
Construction of Highly Substituted Stereodefined Dienes by Cross‐Coupling of α‐Allenic Acetates
Schneekloth J, Pucheault M, Crews C. Construction of Highly Substituted Stereodefined Dienes by Cross‐Coupling of α‐Allenic Acetates. European Journal Of Organic Chemistry 2006, 2007: 40-43. DOI: 10.1002/ejoc.200600721.Peer-Reviewed Original ResearchNatural product chemistryStraightforward reaction conditionsOrganic chemistryProduct chemistryOrganozinc reagentsSubstrate scopeReaction conditionsPalladium precatalystsHigh selectivityZ selectivityCross couplingSelectivityChemistryReactionLigandsDieneInteresting reversalPrecatalystOlefinsReagentsProductsAcetateAssemblyBroad useAppropriate choice