Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing
Moradi L, Witek L, Vivekanand Nayak V, Cabrera Pereira A, Kim E, Good J, Liu C. Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing. Biomaterials 2023, 301: 122289. PMID: 37639975, PMCID: PMC11232488, DOI: 10.1016/j.biomaterials.2023.122289.Peer-Reviewed Original ResearchConceptsΒ-GP hydrogelPorous interconnected structureAmount of GOTissue engineering applicationsEngineering applicationsLong-term storage stabilityInjectable biomaterialsGrowth factor deliveryInjectable hydrogelsInterconnected structureHigh viscosityRapid sol-gel transitionHydrogelsSustained-release propertiesFactor deliveryBiomechanical environmentStorage stabilitySustained deliverySol-gel transitionExcellent candidateCartilage regenerationGel networkSustained releaseChitosanFracture healing