2024
Gray matter volumetric correlates of the polygenic risk of depression: A study of the Human Connectome Project data
Fu X, Chen Y, Luo X, Ide J, Li C. Gray matter volumetric correlates of the polygenic risk of depression: A study of the Human Connectome Project data. European Neuropsychopharmacology 2024, 87: 2-12. PMID: 38936229, DOI: 10.1016/j.euroneuro.2024.06.004.Peer-Reviewed Original ResearchGray matter volumeRegional gray matter volumeGenetic risk of depressionPhenotype of depressionPolygenic risk scoresVoxel-based morphometryRisk of depressionAchenbach Adult Self-ReportRight cerebellum crus ICerebellar gray matter volumeAnterior cingulate volumesPathophysiology of depressionAnterior cingulate cortexCerebellum crus IDSM-oriented scalesMarkers of depressionLeft postcentral gyrusAdult Self-ReportRight gyrus rectusGenetic riskNeural endophenotypesHuman Connectome Project dataDrinking severityHuman Connectome ProjectCingulate volumes
2023
Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain
Luo X, Lin X, Ide J, Luo X, Zhang Y, Xu J, Wang L, Chen Y, Cheng W, Zheng J, Wang Z, Yu T, Taximaimaiti R, Jing X, Wang X, Cao Y, Tan Y, Li C. Male-specific, replicable and functional roles of genetic variants and cerebral gray matter volumes in ADHD: a gene-wide association study across KTN1 and a region-wide functional validation across brain. Child And Adolescent Psychiatry And Mental Health 2023, 17: 4. PMID: 36609385, PMCID: PMC9824933, DOI: 10.1186/s13034-022-00536-0.Peer-Reviewed Original ResearchGray matter volumeAttention deficit hyperactivity disorderTotal intracranial volumeSubcortical gray matter volumesMRNA expressionBasal gangliaEuropean cohortABCD cohortMatter volumeCerebral gray matter volumeRisk of ADHDPathogenesis of ADHDGene-wide association studyAmygdala gray matter volumeRegulatory effectsDeficit hyperactivity disorderBrain cohortSubcortical regionsBrain regionsIntracranial volumeCohortSubcortical structuresADHD risk allelesADHD riskHyperactivity disorder
2022
Subcortical structures associated with childhood trauma and perceived stress in schizophrenia
Fan F, Tan S, Liu S, Chen S, Huang J, Wang Z, Yang F, Li CR, Tan Y. Subcortical structures associated with childhood trauma and perceived stress in schizophrenia. Psychological Medicine 2022, 53: 5654-5662. PMID: 36154670, DOI: 10.1017/s0033291722002860.Peer-Reviewed Original ResearchConceptsGray matter volumeAmygdala gray matter volumeSubcortical gray matter volumesClinical symptomsEarly life traumaChildhood traumaSubcortical structuresCortical gray matter volumePerceived stressTotal cortical gray matter volumeAge-matched controlsSmaller amygdala volumesStructural brain imagingClinical featuresClinical manifestationsTrauma ScoreHealthy controlsChildhood trauma scoresLong-term effectsAmygdala volumePatientsMatter volumeEarly childhood traumaSmaller amygdalaVolumetric correlatesThe relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia
Li H, Chen W, Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Li N, Luo X, Zhang P, Huang J, Tian L, Li CR, Tan Y. The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia. Frontiers In Psychiatry 2022, 13: 966657. PMID: 36051545, PMCID: PMC9424630, DOI: 10.3389/fpsyt.2022.966657.Peer-Reviewed Original ResearchStable chronic schizophreniaNF-κB/ILWhite matter integrityHealthy controlsMATRICS Consensus Cognitive BatteryFractional anisotropyChronic schizophreniaCortical thicknessCognitive impairmentInnate immunityCognitive functionToll-like receptor 4Higher TLR4 levelsLevels of TLR4Subcortical gray matter volumesWhite matter fractional anisotropyNegative Syndrome ScaleGray matter volumeTLR4 expressionTLR4 levelsWhite matter microstructureReceptor 4Cognitive deteriorationConsensus Cognitive BatteryLPS stimulationAlcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence
Luo X, Yang JJ, Buu A, Trucco EM, Li C. Alcohol and cannabis co‐use and longitudinal gray matter volumetric changes in early and late adolescence. Addiction Biology 2022, 27: e13208. PMID: 36001427, PMCID: PMC9413216, DOI: 10.1111/adb.13208.Peer-Reviewed Original ResearchConceptsGray matter volumeLate adolescenceCaudal middle frontal cortexEarly adolescent onsetGray matter volumetric changesMiddle frontal cortexSevere alcohol useBrain developmentCross-sectional findingsSocial cognitionExecutive controlNCANDA studyVolumetric declinesSupramarginal gyrusPotential sex differencesSuperior temporalImpact of alcoholAdolescent onsetSubstance useCortical regionsAlcohol useMatter volumeFrontal cortexResult of alcoholMixed-effects modelingOvernight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers
Chen Y, Dhingra I, Chaudhary S, Fucito L, Li CR. Overnight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers. Nicotine & Tobacco Research 2022, 24: 1889-1897. PMID: 35796689, PMCID: PMC9653081, DOI: 10.1093/ntr/ntac168.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityGray matter volumeWithdrawal symptom severityOvernight abstinenceFunctional connectivityRight SIISymptom severityCigarette smokersSomatosensory cortexMatter volumeRight secondary somatosensory cortexSmaller gray matter volumeSubcortical gray matter volumesSecond somatosensory cortexSecondary somatosensory cortexCortical functional connectivityMotor impulsivityVoxel-wise morphometryRegional gray matter volumeLeft ventral hippocampusGMV alterationsCigarette smokingSatiety stateAbstinence symptomsHigher-order sensory corticesSex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariatesGray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirlsCerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced qualityStriatal gray matter volumes, externalizing traits, and N-back task performance: An exploratory study of sex differences using the human connectome project data
Chen Y, Li C. Striatal gray matter volumes, externalizing traits, and N-back task performance: An exploratory study of sex differences using the human connectome project data. Journal Of Experimental Psychopathology 2022, 13: 20438087221080057. DOI: 10.1177/20438087221080057.Peer-Reviewed Original Research
2021
Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking
Chen Y, Chaudhary S, Wang W, Li C. Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking. Addiction Neuroscience 2021, 1: 100003. PMID: 37220533, PMCID: PMC10201991, DOI: 10.1016/j.addicn.2021.100003.Peer-Reviewed Original ResearchGray matter volumeAnterior cingulate cortexYears of smokingHeavy smokersMatter volumeCingulate cortexSalience networkSmaller gray matter volumeSupplementary motor areaNicotine dependence scoresDorsal anterior cingulate cortexVoxel-based morphometryStructural imaging studiesMedial prefrontal cortexInternalizing scoresChronic smokingCigarette smokingFagerstrom TestInsula gray matter volumeMotor areaNicotine addictionSmokersSmokingImaging studiesDependence scoresPerceived stress, self-efficacy, and the cerebral morphometric markers in binge-drinking young adults
Li G, Le TM, Wang W, Zhornitsky S, Chen Y, Chaudhary S, Zhu T, Zhang S, Bi J, Tang X, Li CR. Perceived stress, self-efficacy, and the cerebral morphometric markers in binge-drinking young adults. NeuroImage Clinical 2021, 32: 102866. PMID: 34749288, PMCID: PMC8569726, DOI: 10.1016/j.nicl.2021.102866.Peer-Reviewed Original ResearchConceptsGray matter volumePerceived stressNeural markersRegional cortical thicknessCortical structuresAlcohol use behaviorsNon-binge drinkersHuman Connectome ProjectChronic alcohol exposure altersCortical thicknessVoxel-based morphometryEmotional distressConnectome ProjectDrinking menPath analysisCortical regionsDrinking womenBinge drinkingMatter volumeYoung adultsUse behaviorsStress regulationPCC thicknessBingeAlcohol exposure altersIdentification of Binge Drinkers via Convolutional Neural Network and Support Vector Machine
Li G, Du S, Niu J, Zhang Z, Gao T, Tang X, Wang W, Li C. Identification of Binge Drinkers via Convolutional Neural Network and Support Vector Machine. 2021, 00: 715-720. DOI: 10.1109/icma52036.2021.9512720.Peer-Reviewed Original ResearchConvolutional neural networkNeural networkGray matter volumeSVM modelSupport vector machineNon-binge drinkersVector machine modelDeep learningVector machinePsychosocial measuresTraining samplesBinge drinkingYoung adult binge drinkingMachine modelAdult binge drinkingHuman Connectome ProjectNetworkPsychosocial markersClassificationConnectome ProjectBinge drinkersCortical thicknessMatter volumeBingeVolumetric differencesAn independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia
Wang Z, Chen W, Cao Y, Dou Y, Fu Y, Zhang Y, Luo X, Kang L, Liu N, Shi YS, Li CR, Xu Y, Guo X, Luo X. An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 385-397. PMID: 33938268, DOI: 10.1177/00048674211009595.Peer-Reviewed Original ResearchConceptsMessenger RNA expressionGray matter volumeMatter volumeSingle nucleotide polymorphismsRisk allelesRNA expressionPathogenesis of schizophreniaSingle nucleotide polymorphism (SNP) rs1006737Isthmus cingulate cortexMinor allele ARisk single nucleotide polymorphismsBrain cohortCingulate cortexBrain regionsCortical regionsSubcortical structuresSchizophreniaRs1006737Allele ARegulatory effectsRisk genesSignificant risk genesCohortCortexAfrican American sample
2020
Age-Related Structural and Functional Changes of the Hippocampus and the Relationship with Inhibitory Control
Hu S, Li CR. Age-Related Structural and Functional Changes of the Hippocampus and the Relationship with Inhibitory Control. Brain Sciences 2020, 10: 1013. PMID: 33352718, PMCID: PMC7766783, DOI: 10.3390/brainsci10121013.Peer-Reviewed Original ResearchStop-signal reaction timeGray matter volumeHippocampal gray matter volumePosterior hippocampusSequential effectsAge-related changesAnterior hippocampal activationTrial reaction timeStop-signal taskDistinct neural markersRight posterior hippocampusSignal reaction timeStop-signal probabilityRegional activityReaction timeAge-Related StructuralCognitive controlCognitive agingHippocampal activationProactive controlSignal taskBehavioral performanceAge-related reductionInhibitory controlHippocampal activityEffects of early ketamine exposure on cerebral gray matter volume and functional connectivity
Hung CC, Liu YH, Huang CC, Chou CY, Chen CM, Duann JR, Li CR, Lee TS, Lin CP. Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity. Scientific Reports 2020, 10: 15488. PMID: 32968108, PMCID: PMC7512006, DOI: 10.1038/s41598-020-72320-z.Peer-Reviewed Original ResearchConceptsGray matter volumeCerebral gray matter volumeKetamine exposureFunctional connectivityMatter volumeKetamine usersBrain structuresLower gray matter volumeFunctional brain changesTreatment of depressionAdolescent-onset groupCerebral functional organizationHigher functional connectivitySuperior frontal gyrusInferior parietal lobuleMedial orbitofrontal cortexSeed-based correlation analysisKetamine groupBrain changesKetamine abuseLarge cohortRight insulaLeft precuneusKetamine misuseRight precuneusAltered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer’s disease
Zheng W, Li H, Cui B, Liang P, Wu Y, Han X, Li C, Li K, Wang Z. Altered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer’s disease. Annals Of Clinical And Translational Neurology 2020, 7: 1919-1929. PMID: 32888399, PMCID: PMC7545587, DOI: 10.1002/acn3.51176.Peer-Reviewed Original ResearchConceptsGray matter volumeHealthy controlsFunctional connectivityBasal nucleusResting-state functional connectivityDaily living statusLower gray matter volumeArterial spin labeling imagingWhole-brain functional connectivityRegional blood flowPostmortem human brainVoxel-based morphometryCholinergic dysfunctionHigher rCBFRight insulaCommon and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group
Rabin RA, Mackey S, Parvaz MA, Cousijn J, Li C, Pearlson G, Schmaal L, Sinha R, Stein E, Veltman D, Thompson PM, Conrod P, Garavan H, Alia‐Klein N, Goldstein RZ. Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. Human Brain Mapping 2020, 43: 543-554. PMID: 32857473, PMCID: PMC8675419, DOI: 10.1002/hbm.25141.Peer-Reviewed Original ResearchConceptsGray matter volumeCocaine useCocaine-dependent individualsMatter volumeCD individualsWhole-brain linear regressionAnterior insulaHippocampal gray matter volumeSelect brain areasT1-weighted MRI scansGender-specific associationsTotal intracranial volumeENIGMA Addiction Working GroupCue-induced cravingLeft anterior insulaGender-specific mechanismsAge-matched participantsCD menCD womenVoxel-based morphometry dataControl menLimbic regionsClinical dataMRI scansBrain areasGray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data
Ide JS, Li HT, Chen Y, Le TM, Li CSP, Zhornitsky S, Li CR. Gray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data. NeuroImage 2020, 220: 117085. PMID: 32592852, PMCID: PMC7572877, DOI: 10.1016/j.neuroimage.2020.117085.Peer-Reviewed Original ResearchConceptsBehavioral activation systemBehavioral inhibition systemGray matter volumeHigher BAS scoresVentral striatumBAS scoresInhibition systemBIS scoresInferior frontal cortexFundamental behavioral traitsTwins/siblingsRight anterior insulaHigher BIS scoresNeural correlatesDevelopmental neuroscienceAnterior insulaVolumetric correlatesVoxel-based morphometry studyInternalizing psychopathologyCerebral basisVoxel-based morphometryBehavioral activationVentral caudateAvoidance traitsMatter volumeKTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson’s Disease
Mao Q, Wang X, Chen B, Fan L, Wang S, Zhang Y, Lin X, Cao Y, Wu YC, Ji J, Xu J, Zheng J, Zhang H, Zheng C, Chen W, Cheng W, Luo X, Wang K, Zuo L, Kang L, Li CR, Luo X. KTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson’s Disease. Frontiers In Neuroscience 2020, 14: 651. PMID: 32655362, PMCID: PMC7324786, DOI: 10.3389/fnins.2020.00651.Peer-Reviewed Original ResearchPutamen gray matter volumesSubstantia nigra pars compactaGray matter volumeParkinson's diseaseMRNA expressionSingle nucleotide polymorphismsPD riskIndependent cohortMatter volumeDevelopment of PDPars compactaDopaminergic neuronsPutamenPutamen volumeSignificant associationPD associationsRisk allelesDiseaseSelective lossCohortGene variants