2023
A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma
Chen Y, Lin X, Zou X, Qian Y, Liu Y, Wang R, Wang X, Yu X, Liu C, Cheng H. A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma. BMC Gastroenterology 2023, 23: 113. PMID: 37024802, PMCID: PMC10080823, DOI: 10.1186/s12876-023-02748-w.Peer-Reviewed Original ResearchConceptsTumor-infiltrating immune cellsExpression of OX40Risk score modelImmune cellsIdentified OX40Immune checkpointsOverall survivalScoring systemRisk scoreClinical specimensExpression of immune checkpoint genesCD8+ T cellsImmune checkpoint gene expressionSomatic mutationsProtein expressionHigh-risk score groupImmunogenic cell deathCheckpoint gene expressionImmune checkpoint expressionImmune checkpoint genesImmune cell infiltrationNaive B cellsCox regression analysisAssociated with increased survival ratesRisk scoring systemAssessing emotional characteristics in Asian autistic adults without intellectual disability
Chien Y, Liu C, Chiu Y, Lin C. Assessing emotional characteristics in Asian autistic adults without intellectual disability. Asian Journal Of Psychiatry 2023, 82: 103472. PMID: 36682157, DOI: 10.1016/j.ajp.2023.103472.Peer-Reviewed Original ResearchConceptsSchutte Emotional Intelligence ScaleAutistic adultsIntellectual disabilityEmotion perceptionSelf-reportEmotional Intelligence ScaleIntelligence ScaleMothers' reportsAutistic malesAutistic featuresEmotional characteristicsSchizophreniaEmotional featuresEmotionsAdultsDisabilitySchuttePerceptionScaleDifficultiesMale
2022
Error patterns of facial emotion recognition in patients with schizophrenia
Lee S, Lin G, Shih C, Chen K, Liu C, Kuo C, Hsieh C. Error patterns of facial emotion recognition in patients with schizophrenia. Journal Of Affective Disorders 2022, 300: 441-448. PMID: 34979185, DOI: 10.1016/j.jad.2021.12.130.Peer-Reviewed Original ResearchConceptsFacial emotion recognitionNegative emotionsError patternsDifferentiation of facesDiscrimination of facesEmotion recognitionHealthy adultsHappy facesResponse biasSchizophreniaTraditional confusion matrixBasic emotionsFacial expressionsEmotionsMethodological issuesAdultsFaceDeficitsFindingsConfusion matrixCliniciansDiscriminationIndividualsInterventionRecognition
2021
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills G, Sun C, Chen G. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. Journal Of Experimental Medicine 2021, 219: e20210789. PMID: 34825915, PMCID: PMC8628262, DOI: 10.1084/jem.20210789.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsAnimalsAntineoplastic Combined Chemotherapy ProtocolsCD8-Positive T-LymphocytesCell Cycle ProteinsCell Line, TumorEndogenous RetrovirusesEnzyme InhibitorsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansImmune Checkpoint InhibitorsMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, SCIDNeoplasms, ExperimentalProtein-Tyrosine KinasesPyrazolesPyrimidinonesRNA, Double-StrandedSignal TransductionTumor BurdenConceptsImmune checkpoint blockadeAnti-tumor immunityEndogenous retroviral elementsWEE1 inhibitionCheckpoint blockadeCD8+ T cell-dependent mannerSensitivity to immune checkpoint blockadeResponse to immune checkpoint blockadeAnti-tumor T cellsCombination of WEE1 inhibitorT cell-dependent mannerPathway-targeted therapiesMultiple tumor modelsPopulation of patientsEmergence of resistanceDown-regulating FoxM1Viral defense pathwaysPD-L1Tumor regressionCombination therapyTargeted therapyCombination partnerT cellsPatient selectionWEE1 inhibitorA quarter of century after: The changing ecology of psychiatric emergency services
Chen W, Hsieh M, Liao S, Liu C, Liu C, Wu C, Lin Y, Hwang T, Chien Y. A quarter of century after: The changing ecology of psychiatric emergency services. Asia-Pacific Psychiatry 2021, 14: e12487. PMID: 34510765, DOI: 10.1111/appy.12487.Peer-Reviewed Original ResearchConceptsMental disordersPsychiatry consultationSuicide/self-harmStressor-related disordersEmergency psychiatric servicesEmergency psychiatry serviceClinical data of genderCommon mental disordersSchizophrenia spectrumEmergency departmentPsychotic disordersDepressive disorderBipolar disorderPsychiatric servicesPsychiatry servicesPsychiatric emergenciesDisordersClinical trainingPsychiatryNeurosisChief complaintED visitsSchizophreniaMedical CenterData of genderThe Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer
Wang Z, Xiao R, Huang J, Qin X, Hu D, Guo E, Liu C, Lu F, You L, Sun C, Chen G. The Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer. Microbial Ecology 2021, 84: 302-313. PMID: 34405250, DOI: 10.1007/s00248-021-01800-0.Peer-Reviewed Original ResearchConceptsLocally advanced cervical cancerLocally advanced cervical cancer patientsPlatinum-based chemotherapy responseAdvanced cervical cancerCervical cancerChemotherapy responseAlpha diversityVaginal microbiotaVaginal samplesCC patientsVaginal microbiomeHealthy controlsPredicting neoadjuvant chemotherapy responsePlatinum-resistant patientsNeoadjuvant chemotherapy responseAssociated with platinum-based chemotherapy responseCervical cancer patientsVaginal microbiota diversityNeoadjuvant chemotherapyHPV infectionBeta diversityBacteroides genusChemotherapy effectCancer patientsBacteroides abundance
2020
Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19
Fu Y, Li Y, Guo E, He L, Liu J, Yang B, Li F, Wang Z, Li Y, Xiao R, Liu C, Huang Y, Wu X, Lu F, You L, Qin T, Wang C, Li K, Wu P, Ma D, Sun C, Chen G. Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19. Annals Of Internal Medicine 2020, 174: m20-3337. PMID: 33284684, PMCID: PMC7745119, DOI: 10.7326/m20-3337.Peer-Reviewed Original ResearchConceptsIndependent risk factorLaboratory-confirmed COVID-19Noncritically ill patientsViral positivityCritically ill patientsIll patientsDisease severityLow IgM titersRisk factorsViral polymerase chain reactionIgM titersCourse of coronavirus disease 2019Serum inflammatory markersIgM positive rateClinically diagnosed casesIgG positivity rateViral positivity rateMedian durationSpecialty care centersSeroconversion ratesAdult patientsInflammatory markersSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Polymerase chain reactionDevelopment of the CAT-FER: A Computerized Adaptive Test of Facial Emotion Recognition for Adults With Schizophrenia.
Lee S, Lin G, Liu C, Chiu E, Hsieh C. Development of the CAT-FER: A Computerized Adaptive Test of Facial Emotion Recognition for Adults With Schizophrenia. American Journal Of Occupational Therapy 2020, 75: 7501205140p1-7501205140p11. PMID: 33399062, DOI: 10.5014/ajot.2020.043463.Peer-Reviewed Original ResearchConceptsFacial emotion recognitionTest of facial emotion recognitionItem bankComputerized adaptive testingRemoval of misfitting itemsClients’ social functioningDiagnosed mental illnessMeasures of facial emotion recognitionAssessment of facial emotion recognitionAdministration modeEmotion recognitionOccupational therapistsMental illnessDomain scoresMisfitting itemsSocial functioningSevere gender biasSchizophreniaRasch modelAdultsItem difficultyImpact of genderItemsScoresProspective usersPrior history of acute pancreatitis predicts poor survival in patients with resectable pancreatic ductal adenocarcinoma
Gong Y, Fan Z, Luo G, Huang Q, Qian Y, Cheng H, Jin K, Ni Q, Yu X, Liu C. Prior history of acute pancreatitis predicts poor survival in patients with resectable pancreatic ductal adenocarcinoma. Pancreatology 2020, 20: 716-721. PMID: 32249060, DOI: 10.1016/j.pan.2020.02.016.Peer-Reviewed Original ResearchConceptsHistory of APPancreatic ductal adenocarcinomaResectable pancreatic ductal adenocarcinomaPancreatic ductal adenocarcinoma patientsLog-rank testAcute pancreatitisSurgical resectionDuctal adenocarcinomaPoor survivalHazard ratioHistory of acute pancreatitisDiagnosis of pancreatic ductal adenocarcinomaAssociated with poor survivalIndependent survival predictorMultivariable-adjusted hazard ratiosKaplan-Meier methodRetrospective cohort studyCox proportional hazards modelsProportional hazards modelOverall survivalRemote historyClinical characteristicsCohort studyMultivariate analysisRisk factorsDevelopment and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia
Wu C, Luedtke A, Sadikova E, Tsai H, Liao S, Liu C, Gau S, VanderWeele T, Kessler R. Development and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia. JAMA Network Open 2020, 3: e1921660. PMID: 32083693, PMCID: PMC7043195, DOI: 10.1001/jamanetworkopen.2019.21660.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaAntipsychotic medicationPrescribed antipsychotic medicationTreatment success rateTreatment successSchizophrenic disordersFirst-episodeSuccess rateSchizophreniaProbability of treatment successTaiwan National Health Insurance Research DatabaseNational Health Insurance Research DatabaseHealth Insurance Research DatabaseEstimating treatment successValidation sampleIndividualized treatment rulesMedicationPrognostic studyPatientsInvestigated biomarkersClinical implementationDischarge diagnosisClinical observationsDemographic dataPragmatic trialKras mutation correlating with circulating regulatory T cells predicts the prognosis of advanced pancreatic cancer patients
Cheng H, Luo G, Jin K, Fan Z, Huang Q, Gong Y, Xu J, Yu X, Liu C. Kras mutation correlating with circulating regulatory T cells predicts the prognosis of advanced pancreatic cancer patients. Cancer Medicine 2020, 9: 2153-2159. PMID: 32017404, PMCID: PMC7064028, DOI: 10.1002/cam4.2895.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCD4 Lymphocyte CountCirculating Tumor DNADNA Mutational AnalysisFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedMutationNeoplasm StagingPancreatic NeoplasmsPolymerase Chain ReactionPrognosisProto-Oncogene Proteins p21(ras)Retrospective StudiesT-Lymphocytes, RegulatoryTime FactorsConceptsCell-free circulating tumor DNAAdvanced pancreatic cancer patientsPancreatic cancer patientsCirculating regulatory T cellsCirculating T-cell subsetsCA19-9 levelsRegulatory T cellsKRAS mutation statusT cell subsetsTumor-node-metastasisCancer patientsMutation statusTumor DNAKRAS mutationsT cellsAssociated with extremely poor survivalRegulatory T cell levelsAdvanced pancreatic cancerLevels of TregsProportion of TregsAbnormal immune statusCirculating tumor DNAT cell levelsPredicted worse prognosisTumor-node-metastasis stageClinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase
Chien Y, Hwu H, Hwang T, Hsieh M, Liu C, Lin-Shiau S, Liu C. Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2020, 99: 109868. PMID: 31954755, DOI: 10.1016/j.pnpbp.2020.109868.Peer-Reviewed Original ResearchConceptsChronic stable schizophreniaNon-psychiatric controlsDisorganized symptomsChronic stable patientsStable schizophreniaWeeks of antipsychotic treatmentStages of schizophreniaAcute relapseClinical implicationsAntipsychotic treatmentNegative symptomsSchizophreniaStable patientsOxidative stressPlatelet superoxide dismutasePlatelet oxidative stressTreatment responseNitric oxideLipid peroxidationLevels of nitric oxideSymptomsSuperoxide dismutaseTreatment effectsRelapsed patientsRelapseResected Pancreatic Cancer With N2 Node Involvement Is Refractory to Gemcitabine-Based Adjuvant Chemotherapy
Liu C, Cheng H, Jin K, Fan Z, Gong Y, Qian Y, Deng S, Huang Q, Ni Q, Yu X, Luo G. Resected Pancreatic Cancer With N2 Node Involvement Is Refractory to Gemcitabine-Based Adjuvant Chemotherapy. Cancer Control 2020, 27: 1073274820915947. PMID: 32268796, PMCID: PMC7153189, DOI: 10.1177/1073274820915947.Peer-Reviewed Original ResearchConceptsGemcitabine-based adjuvant chemotherapyResectable pancreatic cancerPancreatic cancerAdjuvant chemotherapyN2 node involvementNode involvementCurative resection of pancreatic adenocarcinomaResection of pancreatic adenocarcinomaGemcitabine-based regimenGemcitabine-based treatmentNode-positive subgroupEfficacy of gemcitabineGemcitabine-based chemotherapyN2 tumorsAdjuvant regimenNodal involvementNodal statusNode-negativeCurative resectionPancreatic adenocarcinomaSubgroup patientsLymphatic metastasisChemotherapyPatientsCancer
2019
Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test
Li T, Liu C, Liu C, Hsieh M, Lin Y, Wang E, Hwang T, Chou T. Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test. Journal Of The Formosan Medical Association 2019, 119: 439-448. PMID: 31558338, DOI: 10.1016/j.jfma.2019.08.008.Peer-Reviewed Original ResearchConceptsEyes TestNegative emotionsMental statesHealthy controlsSocial cognitive impairmentsChoice patternsStructure of mental statesTaiwanese versionBlunted affectEmotional withdrawalSocial cognitionSocial withdrawalAspect of theoryNegative wordsSchizophreniaEmotionsHigh centralityEmotional aspectsReaction timePoor performanceControl groupImpairmentWithdrawalPatient groupCognitionASO Author Reflections: Resection for Metastasis to the Pancreas—Worthwhile for Selected Patients
Huang Q, Zhou H, Liu C, Yu X. ASO Author Reflections: Resection for Metastasis to the Pancreas—Worthwhile for Selected Patients. Annals Of Surgical Oncology 2019, 26: 696-697. PMID: 31429018, DOI: 10.1245/s10434-019-07621-3.Peer-Reviewed Original ResearchHumansPancreasAJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN
Fan Z, Cheng H, Jin K, Gong Y, Huang Q, Xu J, Ni Q, Yu X, Liu C, Luo G. AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN. World Journal Of Surgical Oncology 2019, 17: 137. PMID: 31387646, PMCID: PMC6685146, DOI: 10.1186/s12957-019-1682-9.Peer-Reviewed Original ResearchConceptsInvasive IPMNInvasive intraductal papillary mucinous neoplasmStage IB diseaseStage IIA diseaseHazard ratioEdition classificationIIA diseaseIB diseaseStaging classificationStaging systemEnd Results cancer registryIntraductal papillary mucinous neoplasmEdition staging systemPredictors of survivalAmerican Joint CommitteeCancer (AJCC) staging systemPapillary mucinous neoplasmConclusionsThe AJCCResectable tumorsAJCC stagingStage IIACancer RegistryTumor sizeMucinous neoplasmsResultsIn totalThe role of necroptosis in cancer biology and therapy
Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K, Cheng H, Jin K, Ni Q, Yu X, Liu C. The role of necroptosis in cancer biology and therapy. Molecular Cancer 2019, 18: 100. PMID: 31122251, PMCID: PMC6532150, DOI: 10.1186/s12943-019-1029-8.Peer-Reviewed Original ResearchConceptsMixed lineage kinase domain-likeReceptor-interacting protein 1Apoptosis resistanceNecrotic cell death modalitiesCell deathMode of programmed cell deathCaspase-independent fashionCancer metastasisTumor progressionLineage kinase domain-likeCancer cellsInduce cancer cell deathCell death modalitiesCell death mechanismsCancer cell deathCancer immunity regulationImmunosuppressive tumor microenvironmentPrognosis of cancer patientsApoptotic pathwayAdaptive immune responsesDeath modalitiesPromote oncogenesisNecroptotic pathwayDeath mechanismsMetabolic signalsGenetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia
Liu C, Liu Y, Hwu H, Fann C, Yang U, Hsu P, Chang C, Chen W, Hwang T, Hsieh M, Liu C, Chien Y, Lin Y, Tsuang M. Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia. Journal Of Human Genetics 2019, 64: 653-663. PMID: 30976040, DOI: 10.1038/s10038-019-0597-1.Peer-Reviewed Original ResearchConceptsDisrupted-in-schizophrenia 1Deficient sustained attentionSchizophrenia patientsContinuous Performance TestFrequency of AA genotypeRisk polymorphismsNeurocognitive subgroupsAssociated with schizophreniaEBV-transformed lymphocytesSustained attentionAA genotypeG alleleMRNA expression levelsA allelePatientsFamilial loadingIntron 4Genetic variantsSchizophreniaIsoform transcriptsGenetic associationSNPsExpression levelsIsoformsESV1
2018
Application of the Eighth Edition of the American Joint Committee on Cancer Staging for Pancreatic Adenocarcinoma
Liu C, Cheng H, Jin K, Guo M, Lu Y, Wang Z, Yang C, Long J, Ni Q, Yu X, Luo G. Application of the Eighth Edition of the American Joint Committee on Cancer Staging for Pancreatic Adenocarcinoma. Pancreas 2018, 47: 742-747. PMID: 29851752, DOI: 10.1097/mpa.0000000000001073.Peer-Reviewed Original ResearchConceptsAmerican Joint Committee on CancerAmerican Joint Committee on Cancer stageTumor resectionPancreatic cancerEighth editionAmerican Joint Committee on Cancer eighth editionAmerican Joint Committee on Cancer seventh editionStage classificationLymph node involvementEnd Results registrySeventh editionPrognosis to patientsNode involvementTumor diameterPositive nodesInstitutional seriesPancreatic adenocarcinomaCancer stageStage distributionSurvival curvesPatientsSurvival analysisTumorStatistical differenceCancerTrajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases
Liu C, Lin Y, Liu C, Hsieh M, Chien Y, Hwang T, Hwu H. Trajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases. Early Intervention In Psychiatry 2018, 13: 895-901. PMID: 29927087, DOI: 10.1111/eip.12696.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisLong-term antipsychotic treatmentAntipsychotic treatmentRecurrence of psychotic symptomsCourse of chronic schizophreniaLow-dose antipsychoticsChronic schizophreniaDysthymic statesPsychotic symptomsDiagnostic stabilityWord lettersRemission criteriaPsychosisAmbiguous informationProbability of relapseCoping strategiesImpending relapseAmbiguous outcomesDiscontinued medicationAntipsychoticsPersonalized formulationsMedication adherencePsychosocial factorsEarly interventionGroup of patients