2021
A quarter of century after: The changing ecology of psychiatric emergency services
Chen W, Hsieh M, Liao S, Liu C, Liu C, Wu C, Lin Y, Hwang T, Chien Y. A quarter of century after: The changing ecology of psychiatric emergency services. Asia-Pacific Psychiatry 2021, 14: e12487. PMID: 34510765, DOI: 10.1111/appy.12487.Peer-Reviewed Original ResearchMeSH KeywordsEmergency Services, PsychiatricFemaleHumansMaleMental DisordersPsychotic DisordersSchizophreniaSelf-Injurious BehaviorSuicideConceptsMental disordersPsychiatry consultationSuicide/self-harmStressor-related disordersEmergency psychiatric servicesEmergency psychiatry serviceClinical data of genderCommon mental disordersSchizophrenia spectrumEmergency departmentPsychotic disordersDepressive disorderBipolar disorderPsychiatric servicesPsychiatry servicesPsychiatric emergenciesDisordersClinical trainingPsychiatryNeurosisChief complaintED visitsSchizophreniaMedical CenterData of gender
2018
Trajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases
Liu C, Lin Y, Liu C, Hsieh M, Chien Y, Hwang T, Hwu H. Trajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases. Early Intervention In Psychiatry 2018, 13: 895-901. PMID: 29927087, DOI: 10.1111/eip.12696.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisLong-term antipsychotic treatmentAntipsychotic treatmentRecurrence of psychotic symptomsCourse of chronic schizophreniaLow-dose antipsychoticsChronic schizophreniaDysthymic statesPsychotic symptomsDiagnostic stabilityWord lettersRemission criteriaPsychosisAmbiguous informationProbability of relapseCoping strategiesImpending relapseAmbiguous outcomesDiscontinued medicationAntipsychoticsPersonalized formulationsMedication adherencePsychosocial factorsEarly interventionGroup of patients
2016
Impact of universal health coverage on urban–rural inequity in psychiatric service utilisation for patients with first admission for psychosis: a 10-year nationwide population-based study in Taiwan
Chiang C, Chen P, Huang L, Kuo P, Tung Y, Liu C, Chen W. Impact of universal health coverage on urban–rural inequity in psychiatric service utilisation for patients with first admission for psychosis: a 10-year nationwide population-based study in Taiwan. BMJ Open 2016, 6: e010802. PMID: 26940114, PMCID: PMC4785302, DOI: 10.1136/bmjopen-2015-010802.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmbulatory CareDatabases, FactualFemaleHealthcare DisparitiesHumansKaplan-Meier EstimateLogistic ModelsMaleMental Health ServicesMiddle AgedNational Health ProgramsPatient AdmissionPsychotic DisordersRetrospective StudiesRural PopulationTaiwanUniversal Health InsuranceUrban PopulationYoung AdultConceptsUniversal health coverageService utilisationUrban-rural residenceUrban-rural inequalitiesHealth coverageUrban patientsEmergency departmentImplementation of universal health coverageImpacts of universal health coverageNationwide population-based studyQuality of careTaiwan National Health Insurance Research DatabaseNational Health Insurance Research DatabaseRural-dwelling patientsHealth Insurance Research DatabasePopulation-based studyUrban-rural differencesPopulation coverage ratePsychiatric outpatient servicesMedical claims recordsNationwide cohort of patientsRisk of readmissionRural patientsUrban-rural gapPsychiatric readmissionTherapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries
Garay R, Citrome L, Samalin L, Liu C, Thomsen M, Correll C, Hameg A, Llorca P. Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries. Expert Opinion On Pharmacotherapy 2016, 17: 921-936. PMID: 26831200, DOI: 10.1517/14656566.2016.1149164.Peer-Reviewed Original ResearchConceptsCognitive impairment associated with schizophreniaSchizoaffective disorderNegative symptomsDopamine D2 receptor partial agonistTreatment of cognitive impairment associated with schizophreniaD2 receptor partial agonistTreating positive symptomsReceptor partial agonistEU clinical trial registriesAdd-on compoundsTardive dyskinesiaPositive symptomsGoal of recoverySchizophreniaPartial agonistAntipsychoticsSchizoaffectivePhase III of clinical developmentTherapeutic improvementDisordersClinical Trials RegistrySymptomsPharmacodynamic profileClinical developmentAcademic medical center
2015
Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis
Liu C, Hua M, Hwang T, Chiu C, Liu C, Hsieh M, Chien Y, Lin Y, Hwu H. Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis. Schizophrenia Research 2015, 164: 40-46. PMID: 25802138, DOI: 10.1016/j.schres.2015.03.006.Peer-Reviewed Original ResearchConceptsUltra-high riskPre-psychotic stateNeurocognitive functionWechsler Adult Intelligence Scale-Third EditionWechsler Memory Scale-Third EditionRisk of transition to psychosisWisconsin Card Sorting TestCard Sorting TestDomains of neurocognitionNeurocognitive function of patientsTransition to psychosisContinuous Performance TestVerbal fluency testTrail Making TestLevels of clinical severityFollow-up assessmentStability of changesSorting TestNeuropsychological batteryOnset of illnessNeurocognitive profileEpisode psychosisFluency testNeurocognitive deficitsFunction of subjects
2013
Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia
Tseng H, Chen S, Liu C, Howes O, Huang Y, Hsieh M, Liu C, Shan J, Lin Y, Hwu H. Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia. PLOS ONE 2013, 8: e66571. PMID: 23818944, PMCID: PMC3688591, DOI: 10.1371/journal.pone.0066571.Peer-Reviewed Original ResearchConceptsEmotion recognition abilityCluster of psychotic symptomsPsychotic symptomsEmotion recognition taskHappy emotionHealthy participantsDysfunction of brain systemsSeverity of psychotic symptomsDeficits of emotion recognitionPresentation of psychotic symptomsDSM-IV diagnostic criteriaRecognition taskPANSS total scoreSensory modalitiesEmotion recognitionRecognition abilityEvaluation of symptomatologySeverity of clinical symptomsHappy prosodyNegative symptomsPerseveration errorsWAIS-IIIDSM-IVEmotional processingBrain systemsAripiprazole for Drug-Naive or Antipsychotic-Short-Exposure Subjects With Ultra-High Risk State and First-Episode Psychosis
Liu C, Chien Y, Hsieh M, Hwang T, Hwu H, Liu C. Aripiprazole for Drug-Naive or Antipsychotic-Short-Exposure Subjects With Ultra-High Risk State and First-Episode Psychosis. Journal Of Clinical Psychopharmacology 2013, 33: 18-23. PMID: 23277261, DOI: 10.1097/jcp.0b013e31827cb017.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisUltra-high riskFirst-episode psychosis patientsDrug-naiveUltra-high risk stateUltra-high-risk patientsLow-dose aripiprazoleNegative symptom scoresPositive symptom scoresFlexible dosing strategyState of psychosisTreatment responseAntipsychotic therapyDrug-naive populationSevere psychopathologyUHR patientsFirst-episodeAripiprazoleAdverse eventsSymptom scoresPsychosisRisk stateConcomitant medicationsTarget doseClinical improvement
2010
Follow-up of subjects with suspected pre-psychotic state in Taiwan
Liu C, Lai M, Liu C, Chiu Y, Hsieh M, Hwang T, Chien Y, Chen W, Hua M, Hsiung P, Huang Y, Hwu H. Follow-up of subjects with suspected pre-psychotic state in Taiwan. Schizophrenia Research 2010, 126: 65-70. PMID: 21112187, DOI: 10.1016/j.schres.2010.10.028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleHumansLongitudinal StudiesMalePsychotic DisordersResidence CharacteristicsSurvival AnalysisTaiwanYoung AdultConceptsFirst-episode psychosisPre-psychotic stateUHR subjectsRate of conversion to psychosisUltra-high-risk groupConversion to psychosisPsychosis risk syndromeFollow-upRisk groupsIntermediate-risk groupNegative symptomsSchizophreniform disorderSchizoaffective disorderPsychotic disordersAntipsychotic useBipolar disorderClinical interviewFollow-up of subjectsOutcomes of subjectsCommunity-based populationRisk syndromeDiagnostic categoriesPsychosisClinical attentionUHRCreating a Platform to Bridge Service and Research for Early Psychosis
Liu C, Hwu H, Chiu Y, Lai M, Tseng H. Creating a Platform to Bridge Service and Research for Early Psychosis. Journal Of The Formosan Medical Association 2010, 109: 543-549. PMID: 20654794, DOI: 10.1016/s0929-6646(10)60089-7.Peer-Reviewed Original ResearchConceptsFull-blown psychosisRisk subjectsPsychopathology progressProspective studyEarly psychosisPerceptual disturbancesLongitudinal prospective studyPsychosisIdentification of subjectsStudy teamEarly identification of subjectsYear oldsEarly interventionClinical entityClinical severityClinicRiskSubjectsAppointmentInterventionYearsIll-definedTeamEnrollment