Immune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd
Takashima S, Sharma R, Egorova A, Kuttiyara J, Ito T, Chang W, Jansen S, Liu C, Lindemans C, Mazutis L, Robine N, Hanash A. Immune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd. Blood 2021, 138: 86-86. DOI: 10.1182/blood-2021-152647.Peer-Reviewed Original ResearchIntestinal stem cellsGene set enrichment analysisMYC expressionIFNG treatmentSTAT1-dependent mannerActivating myc expressionDownstream of Wnt signalingInduced epithelial apoptosisInhibitor 10058-F4Intestinal stem cell maintenanceMYC inhibitor 10058-F4Single cell RNA sequencingIFNG signalingIntestinal stem cell populationIntestinal cryptsCell RNA sequencingGene expression profilesCell cycle analysisUpregulated transcription factorsWnt target gene Axin2Myc functionUpregulation of cyclin D1Sequenced cellsMYC pathwayPhenotypic distances