2024
Long-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer
Kunst N, Long J, Westvold S, Sprenkle P, Kim I, Saperstein L, Rabil M, Ghaffar U, Karnes R, Ma X, Gross C, Wang S, Leapman M. Long-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer. JAMA Network Open 2024, 7: e2440591. PMID: 39441595, DOI: 10.1001/jamanetworkopen.2024.40591.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate-specific antigen levelPSMA-PETRecurrent prostate cancerBiochemical recurrenceProstate cancerLong-term outcomesProstate-specific membrane antigen positron emission tomographyEvaluation of biochemical recurrenceDetection of biochemical recurrenceLife yearsConventional imagingDefinitive local therapyPSMA PET imagingProstate cancer deathDetection of metastasesRetrospective cohort studyBase case analysisIncremental life-yearsPositron emission tomographyDecision-analytic modelLocal therapyConventional imaging strategiesDelayed treatmentDisease courseUSPSTF Colorectal Cancer Screening Recommendation and Uptake for Individuals Aged 45 to 49 Years
Siddique S, Wang R, Yasin F, Gaddy J, Zhang L, Gross C, Ma X. USPSTF Colorectal Cancer Screening Recommendation and Uptake for Individuals Aged 45 to 49 Years. JAMA Network Open 2024, 7: e2436358. PMID: 39361285, PMCID: PMC11450516, DOI: 10.1001/jamanetworkopen.2024.36358.Peer-Reviewed Original ResearchConceptsUS Preventive Services Task ForceUS Preventive Services Task Force recommendationsColorectal cancer screening uptakeAverage-risk individualsScreening uptakeHigher socioeconomic statusSocioeconomic statusScreening recommendationsColorectal cancerColorectal cancer screening recommendationsPreventive Services Task ForceCohort studyCancer screening recommendationsScreening uptake ratesInterrupted time series analysisLow socioeconomic statusPrivate insurance beneficiariesScreening ratesSocioeconomic disparitiesRetrospective cohort studyMain OutcomesPotential disparitiesEvaluate changesClaims dataAbsolute changeImmunotherapy utilization patterns in patients with advanced cancer and autoimmune disease
Li H, Huntington S, Gross C, Wang S. Immunotherapy utilization patterns in patients with advanced cancer and autoimmune disease. PLOS ONE 2024, 19: e0300789. PMID: 38625861, PMCID: PMC11020359, DOI: 10.1371/journal.pone.0300789.Peer-Reviewed Original ResearchConceptsAutoimmune diseasesImmunotherapy cycleFirst-lineNon-small cell lung cancerAdvanced cancerFirst-line immunotherapyOverall treatment toleranceCell lung cancerRenal cell carcinomaRetrospective cohort studyAssociated with lower oddsAdvanced melanomaCell carcinomaTreatment toleranceAbsolute contraindicationImmunotherapyConsensus guidelinesImprove cancer survivalLung cancerCohort studyClinical variablesCancer patientsAcademic centersPatientsIncidence rateArea Vulnerability and Disparities in Therapy for Patients With Metastatic Renal Cell Carcinoma
Rahman S, Long J, Westvold S, Leapman M, Spees L, Hurwitz M, McManus H, Gross C, Wheeler S, Dinan M. Area Vulnerability and Disparities in Therapy for Patients With Metastatic Renal Cell Carcinoma. JAMA Network Open 2024, 7: e248747. PMID: 38687479, PMCID: PMC11061765, DOI: 10.1001/jamanetworkopen.2024.8747.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaArea-level measuresRenal cell carcinomaPatient-level factorsSystemic therapyEthnic disparitiesRelative risk ratiosSocially vulnerable areasCell carcinomaMeasures of social vulnerabilityMedicare beneficiariesCohort studyFee-for-service Medicare Parts AOdds ratioReceipt of systemic therapyLogistic regressionArea-level characteristicsAssociated with lack of treatmentNon-Hispanic blacksRetrospective cohort studyIndividual-level demographicsNon-Hispanic whitesAssociated with disparitiesUS Medicare beneficiariesMeasures of disadvantage
2023
Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US
Kc M, Fan J, Hyslop T, Hassan S, Cecchini M, Wang S, Silber A, Leapman M, Leeds I, Wheeler S, Spees L, Gross C, Lustberg M, Greenup R, Justice A, Oeffinger K, Dinan M. Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US. JAMA Network Open 2023, 6: e2323115. PMID: 37436746, PMCID: PMC10339147, DOI: 10.1001/jamanetworkopen.2023.23115.Peer-Reviewed Original ResearchConceptsLong-term survivorsCancer-specific mortalityColorectal cancerCancer cohortReceptor statusInitial diagnosisGleason scoreProstate cancerBreast cancerLong-term adult survivorsMedian cancer-specific survivalEnd Results cancer registryProstate-specific antigen levelRectal cancer cohortCancer-specific survivalStage III diseaseYear of diagnosisProgesterone receptor statusEstrogen receptor statusProportion of deathsSurvival time ratioEarly-stage cancerNononcologic outcomesIndex cancerLocalized diseaseDisparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma
Chow R, Long J, Hassan S, Wheeler S, Spees L, Leapman M, Hurwitz M, McManus H, Gross C, Dinan M. Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma. JNCI Cancer Spectrum 2023, 7: pkad036. PMID: 37202354, PMCID: PMC10276895, DOI: 10.1093/jncics/pkad036.Peer-Reviewed Original ResearchConceptsOral anticancer agentsTherapy utilizationMedicare beneficiariesNon-Hispanic white raceMetastatic renal cell carcinomaNon-Hispanic black raceOlder US patientsUS Medicare beneficiariesRenal cell carcinomaLogistic regression modelsTherapy receiptMultivariable adjustmentSystemic therapyMale sexUS patientsCell carcinomaStudy criteriaBlack raceFemale sexPatient raceWhite raceImmunotherapyOutcomes persistSexPatientsPerceived appropriateness of assessing for health-related socioeconomic risks among adult patients with cancer
Vu M, Boyd K, De Marchis E, Garnache B, Gottlieb L, Gross C, Lee N, Lindau S, Mun S, Winslow V, Makelarski J. Perceived appropriateness of assessing for health-related socioeconomic risks among adult patients with cancer. Cancer Research Communications 2023, 3: 521-531. PMID: 37020993, PMCID: PMC10069714, DOI: 10.1158/2767-9764.crc-22-0283.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth care settingsAdult patientsCare settingsHealth care-related factorsCare-related factorsPerceptions of patientsAmerican Cancer SocietyFisher's exact testNational Cancer InstituteMost patientsOutpatient clinicCancer SocietySocioeconomic riskCancer InstitutePatientsExact testSelf-administered surveyEHR documentationSignificant associationSociodemographic characteristicsClinical settingCancerHealthcare settingsCancer treatmentAssociation Between Age and Survival Trends in Advanced Non–Small Cell Lung Cancer After Adoption of Immunotherapy
Voruganti T, Soulos P, Mamtani R, Presley C, Gross C. Association Between Age and Survival Trends in Advanced Non–Small Cell Lung Cancer After Adoption of Immunotherapy. JAMA Oncology 2023, 9: 334-341. PMID: 36701150, PMCID: PMC9880865, DOI: 10.1001/jamaoncol.2022.6901.Peer-Reviewed Original ResearchConceptsAdvanced non-small cell lung cancerNon-small cell lung cancerImmune checkpoint inhibitorsUse of ICIsPatients 75 yearsCell lung cancerDrug Administration approvalCohort studyOlder patientsLung cancerAdministration approvalUS FoodAdoption of immunotherapyMedian overall survivalCancer-directed therapySubstantial survival benefitFirst US FoodCheckpoint inhibitorsStage IIIBClinical characteristicsICI useMedian survivalOverall survivalSurvival benefitSurvival gainUse of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation
Leapman M, Wang R, Loeb S, Seibert T, Gaylis F, Lowentritt B, Brown G, Chen R, Lin D, Witte J, Cooperberg M, Catalona W, Gross C, Ma X. Use of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation. Journal Of Urology 2023, 209: 710-718. PMID: 36753746, DOI: 10.1097/ju.0000000000003159.Peer-Reviewed Original ResearchConceptsIntermediate-risk prostate cancerMixed-effects Poisson regressionPSA testingProstate biopsyProstate cancerEffects Poisson regressionMedicare beneficiariesPoisson regressionAdditional prostate biopsyRetrospective cohort studyProstate MRILocalized prostate cancerRepeat prostate biopsyRate of biopsyRace/ethnicityCensus tract povertyMedian followCohort studyMedian ageMonitoring testsProvider factorsPSA testClinical riskBiopsySociodemographic factors
2022
Racial and Ethnic Differences in Internal Medicine Residency Assessments
Boatright D, Anderson N, Kim J, Holmboe E, McDade W, Fancher T, Gross C, Chaudhry S, Nguyen M, Tiako M, Colson E, Xu Y, Li F, Dziura J, Saha S. Racial and Ethnic Differences in Internal Medicine Residency Assessments. JAMA Network Open 2022, 5: e2247649. PMID: 36580337, PMCID: PMC9857126, DOI: 10.1001/jamanetworkopen.2022.47649.Peer-Reviewed Original Research
2021
Association Between Sexual Orientation, Mistreatment, and Burnout Among US Medical Students
Samuels EA, Boatright DH, Wong AH, Cramer LD, Desai MM, Solotke MT, Latimore D, Gross CP. Association Between Sexual Orientation, Mistreatment, and Burnout Among US Medical Students. JAMA Network Open 2021, 4: e2036136. PMID: 33528552, PMCID: PMC7856540, DOI: 10.1001/jamanetworkopen.2020.36136.Peer-Reviewed Original ResearchConceptsOdds of burnoutAAMC Graduation QuestionnaireMedical studentsSexual orientationAssociated with increased odds of burnoutGraduation QuestionnaireMedical schoolsPoor quality careHeterosexual studentsProbability of burnoutFear of discriminationUS allopathic medical schoolsAssociated with increased oddsExperiences of mistreatmentUS medical studentsAllopathic medical schoolsCross-sectional studyMedical student burnoutLogistic regression modelsSexual minority groupsQuality careOldenburg Burnout Inventory for Medical StudentsLGB sexual orientationTrainee burnoutMain Outcomes
2020
Is there variation in private payor payments to cancer surgeons? A cross-sectional study in the USA
Bongiovanni T, Kim SP, Kim A, Killelea B, Gross C. Is there variation in private payor payments to cancer surgeons? A cross-sectional study in the USA. BMJ Open 2020, 10: e035438. PMID: 33020076, PMCID: PMC7537435, DOI: 10.1136/bmjopen-2019-035438.Peer-Reviewed Original ResearchAssessment of the Prevalence of Medical Student Mistreatment by Sex, Race/Ethnicity, and Sexual Orientation
Hill KA, Samuels EA, Gross CP, Desai MM, Zelin N, Latimore D, Huot SJ, Cramer LD, Wong AH, Boatright D. Assessment of the Prevalence of Medical Student Mistreatment by Sex, Race/Ethnicity, and Sexual Orientation. JAMA Internal Medicine 2020, 180: 653-665. PMID: 32091540, PMCID: PMC7042809, DOI: 10.1001/jamainternmed.2020.0030.Peer-Reviewed Original ResearchConceptsAllopathic US medical schoolsMedical student mistreatmentUS medical schoolsLGB studentsUnderrepresented minoritiesMedical schoolsStudent mistreatmentMultiracial studentsStudent sexWhite studentsMedical studentsFemale studentsMale studentsHeterosexual studentsAmerican Medical Colleges Graduation QuestionnaireSexual orientationCohort study analyzed dataUS medical studentsEpisodes of mistreatmentGraduating US medical studentsGraduation QuestionnaireStudent surveysStudy analyzed dataMedical educationStudents
2018
Factors Associated With Cancer Disparities Among Low-, Medium-, and High-Income US Counties
O’Connor J, Sedghi T, Dhodapkar M, Kane MJ, Gross CP. Factors Associated With Cancer Disparities Among Low-, Medium-, and High-Income US Counties. JAMA Network Open 2018, 1: e183146. PMID: 30646225, PMCID: PMC6324449, DOI: 10.1001/jamanetworkopen.2018.3146.Peer-Reviewed Original ResearchConceptsCancer death ratesDeath rateHigh-income countiesCancer disparitiesPossible mediatorsAge-standardized cancer death ratesLow-income countiesCross-sectional studyClinical care factorsIncome-related disparitiesNon-Hispanic blacksHealth risk behaviorsLow-quality careUS countiesPhysical inactivityCare factorsMAIN OUTCOMEFair healthDeath recordsMedian household incomeMedian incomeHealth StatisticsRisk behaviorsHealth policyCounty income levels
2017
Use of Alternative Medicine for Cancer and Its Impact on Survival
Johnson SB, Park HS, Gross CP, Yu JB. Use of Alternative Medicine for Cancer and Its Impact on Survival. Journal Of The National Cancer Institute 2017, 110: djx145. PMID: 28922780, DOI: 10.1093/jnci/djx145.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBreast NeoplasmsChoice BehaviorColorectal NeoplasmsComorbidityComplementary TherapiesEducational StatusFemaleHumansIncomeLung NeoplasmsMaleNeoplasm StagingNorthwestern United StatesPacific StatesPatient PreferenceProstatic NeoplasmsResidence CharacteristicsSex FactorsSurvival RateConceptsConventional cancer treatmentsAlternative medicineColorectal cancerCox proportional hazards regressionGreater riskLower comorbidity scoreMultivariable logistic regressionProportional hazards regressionPatterns of utilizationHigher socioeconomic statusNonmetastatic breastComorbidity scoreHormone therapyCurable cancerHazards regressionLung cancerAM useAnticancer treatmentStage IICancerIndependent covariatesLogistic regressionPatientsCancer treatmentSocioeconomic status
2015
Regional-Level Correlations in Inappropriate Imaging Rates for Prostate and Breast Cancers: Potential Implications for the Choosing Wisely Campaign
Makarov DV, Soulos PR, Gold HT, Yu JB, Sen S, Ross JS, Gross CP. Regional-Level Correlations in Inappropriate Imaging Rates for Prostate and Breast Cancers: Potential Implications for the Choosing Wisely Campaign. JAMA Oncology 2015, 1: 185-194. PMID: 26181021, PMCID: PMC4707944, DOI: 10.1001/jamaoncol.2015.37.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBreast NeoplasmsCatchment Area, HealthChi-Square DistributionDiagnostic ImagingFemaleGuideline AdherenceHumansLogistic ModelsMaleMedicareMultivariate AnalysisPractice Guidelines as TopicPractice Patterns, Physicians'Predictive Value of TestsProstatic NeoplasmsResidence CharacteristicsRetrospective StudiesRisk FactorsSEER ProgramUnited StatesUnnecessary ProceduresConceptsLow-risk prostate cancerProstate cancerBreast cancerProstate cancer imagingFourth quartileLow-risk breast cancerBreast cancer imagingLow-risk prostateEnd Results-MedicareRetrospective cohort studyMultivariable logistic regressionChoosing Wisely campaignPatient-level analysisAppropriateness of careHospital referral regionsCancer imagingQuality of careInappropriate imagingCohort studyWisely campaignHealth care spendingLowest quartileOdds ratioPatient levelHRR level
2012
Proton Versus Intensity-Modulated Radiotherapy for Prostate Cancer: Patterns of Care and Early Toxicity
Yu JB, Soulos PR, Herrin J, Cramer LD, Potosky AL, Roberts KB, Gross CP. Proton Versus Intensity-Modulated Radiotherapy for Prostate Cancer: Patterns of Care and Early Toxicity. Journal Of The National Cancer Institute 2012, 105: 25-32. PMID: 23243199, PMCID: PMC3536640, DOI: 10.1093/jnci/djs463.Peer-Reviewed Original ResearchConceptsIntensity-modulated radiotherapyProstate cancerMedicare beneficiariesGenitourinary toxicityEarly toxicityProton radiotherapyMultivariable logistic regressionPatterns of careMain outcome measuresType of radiotherapyMedicare reimbursementClinical benefitRetrospective studyPRT patientsOutcome measuresComprehensive cohortPRT useIMRT patientsPatientsSociodemographic characteristicsRadiotherapyCancerLogistic regressionMonthsSignificant differences
2006
The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening.
Gross CP, McAvay GJ, Krumholz HM, Paltiel AD, Bhasin D, Tinetti ME. The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening. Annals Of Internal Medicine 2006, 145: 646-53. PMID: 17088577, DOI: 10.7326/0003-4819-145-9-200611070-00006.Peer-Reviewed Original ResearchConceptsChronic illnessColorectal cancerChronic conditionsLife expectancyCancer stageEarly-stage colorectal cancerPopulation-based cancer registriesPatients 67 yearsRetrospective cohort studyStage I cancerAdministrative claims dataChronic condition groupsFinal study sampleYears of ageShort life expectancyCohort studyEffect of agePatient ageI cancerCancer RegistryCancer variesHealthy patientsIndividual patientsMedicare claimsAdministrative claims
2004
Participation in Cancer Clinical Trials: Race-, Sex-, and Age-Based Disparities
Murthy VH, Krumholz HM, Gross CP. Participation in Cancer Clinical Trials: Race-, Sex-, and Age-Based Disparities. JAMA 2004, 291: 2720-2726. PMID: 15187053, DOI: 10.1001/jama.291.22.2720.Peer-Reviewed Original ResearchConceptsCancer trialsCancer clinical trialsClinical trialsTrial participantsEnrollment fractionWhite patientsAge groupsCross-sectional population-based analysisProstate cancer clinical trialsCancer research participationCancer trial participantsColorectal cancer trialsPatients 75 yearsIncident cancer patientsLung cancer trialsPopulation-based analysisRelative risk ratiosAge-based disparitiesYears of ageNational Cancer InstituteLogistic regression modelsLittle recent informationTrial enrolleesYounger patientsPatient group
1999
Management of Barrett's esophagus: a national study of practice patterns and their cost implications
Gross C, Canto M, Hixson J, Powe N. Management of Barrett's esophagus: a national study of practice patterns and their cost implications. The American Journal Of Gastroenterology 1999, 94: ajg1999806. PMID: 10606300, DOI: 10.1111/j.1572-0241.1999.01606.x.Peer-Reviewed Original ResearchConceptsHigh-grade dysplasiaDirect medical costsBarrett's esophagusEndoscopic surveillancePractice patternsMedical costsAge 45 yrNational cross-sectional surveyCurrent practice patternsLow-grade dysplasiaMajority of cliniciansFrequency of endoscopyDegree of dysplasiaPopulation-based estimatesCross-sectional surveySurveillance endoscopyNonclinical factorsBE patientsPhysician ageCost implicationsFrequent surveillanceDysplasiaGastroenterologistsClinical decisionOptimal management